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Keratoconus (KC) is a relatively common disease of the cornea, the clear curved part at the front of the eye needed for good vision. KC leads to loss of corneal transparency, thinning and shape changes that affect vision and quality of life. Why the cornea degenerates in KC is complex but involves environmental and genetic factors. To help identify candidate genes critical in KC we analysed global gene expression. Two novel genes (Notch1 and PLLP) were decreased in KC - these genes affect the normal way corneal cells grow and migrate, and signal to each other. We will now study the function of these genes in human corneas to assess their r...

Vision relies on the exchange of information between the eye and the brain through a million nerve fibres forming the optic nerve. This makes the optic nerve head, the exit point of these fibres from the eye, arguably the most important structure to assess eye health. The increasing number of methods available to visualise this structure in the back of the eye, however, can be confusing for patients and clinicians alike.