Clinical examination of ocular diseases relies upon a battery of tests to reveal structural and functional losses. In some cases, there may be discordance between structural and functional measurements. A classic example is pre-perimetric glaucoma, in which overt structural losses are apparent in the absence of clinically detectable functional deficits. Discordance between techniques can also manifest as differences in the magnitude of loss detected using various perimetric methods, such as static and kinetic perimetry. Tests of structure and function are important, so is there a way to reconcile the discordance apparent between them? This presentation will outline some of the methods established by our laboratory working towards reconciling discordance between clinical techniques, and their application for assessment of ocular diseases.