Research News

Well, another strange year to be sure…. COVID-19 is still affecting all of our lives, but fortunately our research was not as affected as some of our colleagues in other universities in Australia or overseas. In fact, we had another very successful and productive year.

We also moved Faculties in 2021, from the Faculty of Science to the Faculty of Medicine and Health. We have kept our collaborations with colleagues from Science, but it has been exciting and rewarding to meet our new Faculty colleagues and start developing new research collaborations.

Recognition:

Expertscape published an analysis of expertise in contact lenses worldwide, based on 3,824 eligible articles published since 2011. We were very pleased to see that UNSW, led by our School, was the top-rated institution publishing in this field. Not only that but Scientia Professor Fiona Stapleton was 2nd in the world ranking for experts in this field, with Professor Mark Willcox, Associate Professor Nicole Carnt and Emeritus Professor Eric Papas named in the top 20. Many congratulations to SOVS Visiting Professor, Lyndon Jones who topped this list. We are also pleased to see that Associate Professor Nicole Carnt topped the global ranking for Keratitis.

Awards:

January 2021 saw Professor Willcox awarded an ARVO Gold Fellowship and Visiting Professor Alison McDermott awarded an ARVO Silver Fellowship. To be bestowed an ARVO Fellow is an honour and it was established to recognise current ARVO members for their individual accomplishments, leadership and contributions to the Association.

In October 2021, Professor Konrad Pesudovs was awarded the American Academy of Optometry Foundation Glenn Fry Award and Lecture.  This award recognises a distinguished scientist or clinician for their current research contributions. The award is given annually to a distinguished scientist or clinician scientist in recognition of the quality, significance, impact, and relevance to optometry of his or her current research contributions.

Grants:

We are really excited to say that in every category of grant funding – Category 1 (NHMRC, ARC grants), Category 2 (Other Public Sector Research Income) and Category 3 (private sector, philanthropic and international sources) – we exceeded our funding from 2020.

In October 2021 Professor Lisa Keay and colleagues were awarded funding from the Australian Federal Government, Road Safety Innovation Fund for a project titled Increasing older drivers’ competency and confidence in the use of advance vehicle technologies (AVT). Professor Keay was also awarded a National Health & Medical Research Council Ideas Grant with Associate Professor Julie Brown from The George Institute for Global Health, UNSW. Professor Keay is also an investigator on the Australian Eye and Ear Health Survey, with colleagues at Westmead Institute for Medical Research, University of Sydney, Macquarie University, The George Institute for Global Health and Brien Holden Foundation.

Associate Professor Juno Kim was awarded an ARC Discovery Project entitled “Unleashing the potential of VR: reducing sickness in head-mounted displays” with colleagues from the University of Wollongong.

Dr Sheela Kumaran, a Postdoctoral Research Fellow at UNSW School of Optometry and Vision Science was awarded a Macular Disease Foundation Australia (MDFA) research grant at a ceremony at Admiralty House in Sydney on 20 May 2021 by his Excellency, the Honourable David Hurley, Governor-General of Australia.

sheela kumaran

In July 2021 Dr Jerome Ozkan, Lecturer and Research Fellow at UNSW School of Optometry and Vision Science was awarded the 2021 Macular Degeneration Grant from the Estate of the late Peter Anthony John Vild. Jerome is studying differences in the microorganisms on the conjunctiva (ocular microbiome) and proteins in the tears (tear proteome) of patients with dry-AMD compared to wet-AMD and healthy controls.

Also in July, Dr Shyam Tummanapalli was awarded the Diabetes Research Grant from the Elizabeth O’Beirne and Robert and Emmy Mather Trust Fund. Shyam will investigate the relationship of tear film nitric oxide with corneal and peripheral neuropathy in people with diabetes and assess whether tear film nitric oxide concentration can be used as a non-invasive biomarker for the development of peripheral neuropathy in diabetes.

Associate Professor Nicole Carnt was awarded a Rebecca L Cooper Medical Research Foundation Project Grant entitled Preventing Sight Loss from Cold Sore Infections of the Eye just as the last newsletter was being written, and so we congratulate her on this now as the grant spans 2020/2021. In 2021, Nicole was also awarded a PLuS Alliance Seed Funding Grant with colleagues at Kings College in London, investigating tear signals in keratitis.

The Eye Research Group (ERG) led by Senior Research Fellow Dr Jacqueline Tan and Scientia Professor Fiona Stapleton continues to grow from strength to strength. The ERG is an exemplar of industry collaboration and has grown in specialised equipment and personnel.

Publications:

Ok, you know the story by now… we beat last year’s number of quartile 1 publications in 2021! We are proud to announce that we published a grand total of 328 papers for 2021. One of the highlights were the publication of the BCLA Contact Lens Evidence-based Academic Reports (CLEAR) reports published in April 2021 issue of Contact Lens that had contributions from many of our staff (Willcox, Vijay, Tan, Siddireddy, Stapleton, Maseedupally, Masoudi, Mobeen, Kang, Jalbert, Hui, Golebiowski, Carnt) and visiting academic staff (Debarun Dutta, Alison McDermott, Lyndon Jones, Philip Morgan, Ravi Bakaraju, Paul Gifford, Craig Woods, Padmaja Sankaridurg).

Here are some that are published as Open Access, and free for you to download and read:

  1. Burton et al. The Lancet Global Health Commission on Global Eye Health: vision beyond 2020. The Lancet Global Health Commission 2021; 9: E489-E551.
  2. Szczotka-Flynn et al. American Academy of Optometry Microbial Keratitis Think Tank. Optometry and Vision Science. 2021; 98: 182-198.
  3. Thomson et al. Lifetime Corneal Edema Load Model. Translational Vision Science & Technology. 2021; 10: 34.
  4. Sankaridurg et al. IMI Impact of Myopia. Investigative Ophthalmology & Visual Science. 2021; 62: 2.
  5. Khou et al. Review of referrals reveal the impact of referral content on the triage and management of ophthalmology wait lists. BMJ Open. 2021; 11: e047246
  6. Ali et al. The effect of blue light filtering lenses on speed perception. Scientific Reports. 2021; 11: 17583
  7. Yasir et al. Antiviral effect of multipurpose contact lens disinfecting solutions against coronavirus. Contact Lens and Anterior Eye. doi:10.1016/j.clae.2021.101513
  8. Erickson et al. TFOS: Unique challenges and unmet needs for the management of ocular surface diseases throughout the world. The Ocular Surface. 2021; 22: 242-244
  9. Jonas et al. IMI Prevention of Myopia and Its Progression. Investigative Ophthalmology & Visual Science 2021; 62: 6.
  10. Tong et al. Topical Review: Assessment of Binocular Sensory Processes in Low Vision. Optometry and Vision Science. 2021; 98: 310-325

 

Professor Mark Willcox, Director of Research

Associate Professor Nicole Carnt, Deputy Director of Research

Previous Research News

2020

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It is now a cliché to say, but this certainly has been a year to remember. Despite all of the issues we had this year, research continued, and our outputs and outcomes even grew. In 2020 thus far, we have published 196 journal articles. These include twenty-five in Clinical and Experimental Optometry, thirteen in Contact Lens and Anterior Eye, twelve in British Journal of Ophthalmology and seven in Ophthalmic and Physiological Optics.

All conferences went on-line after March, which was a challenge for scheduling, sleeping and attendance. Before lockdown began, several of us, Dr Jerome Ozkan, Dr Nicole Carnt, Ms Rabia Mobeen, Ms Zahra Tajbakhsh, Mr Hari Peguda and Mr Gauri Shrestha presented our research at the Gordon Conference on the Cornea and Ocular Surface Biology. This was held in Tuscany, Italy from 16-21st February. Nicole and I also chaired the GRC Power Hour that took place on the first day. This was designed to address issues that women face in science as well as issues of diversity and inclusion which I thought generated some great discussions. We also discovered that in the UK sending and responding to emails over the weekend is discouraged. Now, if only we could establish that practice elsewhere…

Gordon Conference

Following on from the success of Dr Nivison-Smith in the NHMRC grants, Prof Michael Kalloniatis received an Ideas grant entitled “Predicting visual function from structural data in health and ocular disease” and I was also successful in the same scheme “Tackling Hospital Acquired Infections with Peptide Mimics.” Indeed, my grant was awarded the highest score of all the 2019 Ideas grants, and for that I won the NHMRC Marshall and Warren Ideas Grant Award.

Prof Pesudovs joined the School through the highly competitive SHARP pathway at UNSW. He was awarded the H Barry Collin Medal for 2020. We warmly welcome him and look forward to working with him in his research areas of ophthalmic surgical outcomes, including optical, visual and patient-reported outcomes, ophthalmic epidemiology and neural adaptation.

Scientia Professor Fiona Stapleton has had a stellar year. She was listed as one of the top 250 Australian Researchers in September. Scientia Prof Stapleton and Prof Michael Kalloniatis received funding to investigate the use of artificial intelligence to diagnose, manage and refer patients. Part of this funding was secured from Big Picture Medical and the CRC-P granting system.

While the above grants and awards are extremely exciting and gratifying, it is the achievements of our Early Career Researchers and PhD students that augurs well for the future of the School. Some of their achievements include the award to Dr Shyam Tummanapalli of the Dean’s Award for Outstanding PhD thesis, the 2020 William C. Ezell (Rod Tahran / Essilor) Fellowship by the American Academy of Optometry Foundation to Ms Rabia Mobeen and Promotion of Dr Jerome Ozkan to Research Fellow. We highlight their achievements on our website (https://www.optometry.unsw.edu.au/news-events/latest-newshttps://www.optometry.unsw.edu.au/news-events/media-0).

Shyam award
Rabia Ezell Fellow

So, congratulations for everyone for their hard work, resilience, and success in 2020 and congratulations to all award winners. The School continues to produce world-class research and we are looking forward to 2021 and the move to the Faculty of Medicine to see what new opportunities that brings.

The following 10 papers are some of those that we have been published as open access. We do this so you can review our work – click on the hyperlinks below to read:

  1. Dillon L, Clemson L, Nguyen H, Jakobsen KB, Martin J, Tinsley F, Keay L. Recipient and instructor perspectives of an adapted exercise-based fall prevention programme for adults aged 50+ years with vision impairment: a qualitative study nested within a randomised controlled trial. BMJ Open. 2020; 10(9): e038386.
  2. Downie LE, Hom MM, Berdy GJ, El-Harazi S, Verachtert A, Tan J, Liu H, Carlisle-Wilcox C, Simmons P, Vehige J. An artificial tear containing flaxseed oil for treating dry eye disease: A randomized controlled trial. Ocul Surf. 2020 Jan;18(1):148-157.
  3. Fu A, Watt K, M Junghans B, Delaveris A, Stapleton F. Prevalence of myopia among disadvantaged Australian schoolchildren: A 5-year cross-sectional study. PLoS One. 2020 Aug 27;15(8):e0238122.
  4. Jones L, Walsh K, Willcox M, Morgan P, Nichols J. The COVID-19 pandemic: Important considerations for contact lens practitioners. Cont Lens Anterior Eye. 2020 Jun;43(3):196-203.
  5. Junghans BM, Azizoglu S, Crewther SG. Unexpectedly high prevalence of asthenopia in Australian school children identified by the CISS survey tool. BMC Ophthalmol. 2020 Oct 12;20(1):408.
  6. Khan M, Stapleton F, Summers S, Rice SA, Willcox MDP. Antibiotic Resistance Characteristics of Pseudomonas aeruginosa Isolated from Keratitis in Australia and India. Antibiotics (Basel). 2020 Sep 14;9(9):600.
  7. Tahhan N, Ford BK, Angell B, Liew G, Nazarian J, Maberly G, Mitchell P, White AJR, Keay L. Evaluating the cost and wait-times of a task-sharing model of care for diabetic eye care: a case study from Australia. BMJ Open. 2020 Oct 5;10(10):e036842.
  8. Tong J, Alonso-Caneiro D, Yoshioka N, Kalloniatis M, Zangerl B. Custom extraction of macular ganglion cell-inner plexiform layer thickness more precisely co-localizes structural measurements with visual fields test grids. Sci Rep. 2020 Oct 28;10(1):18527.
  9. Yadav UN, Rayamajhee B, Mistry SK, Parsekar SS, Mishra SK. A Syndemic Perspective on the Management of Non-communicable Diseases Amid the COVID-19 Pandemic in Low- and Middle-Income Countries. Front Public Health. 2020 Sep 25;8:508.
  10. Willcox MDP,  Walsh K,  Nichols JJ, Morgan PB, Jones JW. The ocular surface, coronaviruses and COVID‐19. Clin Exp Optom. 2020 Jul; 103(4): 418-424.

Professor Mark Willcox,

Director of Research

2019

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2019 - A bumper year for SOVS in research

We are especially pleased with the announcement that Dr Lisa Nivison-Smith has been awarded an NHMRC Investigator Grant for her research into inner retinal remodelling in AMD. Her work may lead to improvements in the clinical assessment of AMD through identifying further prognostic biomarkers for the disease, leading to better risk assessment and more individually tailored management of the condition. These grants are incredibly competitive, and it is a testament to Lisa’s research that she was awarded this prestigious grant.

We also congratulate Dr Simin Masoudi and Dr Maria Markoulli (pictured below), who were selected as UNSW Women in Maths and Science Champions. The program develops the career and leadership skills of early career scientists while reaching out to girls and women in the community to encourage them to pursue a career in maths and science.

Dr Simin Masoudi and Dr Maria Markoulli

In July 2019 several members of the School (Professor Mark Willcox, Mr Muhammad Yasir, Dr Dinesh Subedi and Mr Parthasarathi Kalaiselvan) attended the workshop “Tackling Antimicrobial Resistance together: NUW Alliance Workshop to develop a joint Antimicrobial Research Taskforce”

NUW Alliance

This joint Antimicrobial Research Taskforce (NUW-ART) involved academics from University of Newcastle, UNSW and University of Wollongong as part of their NUW Alliance program.  Also in attendance was Prof Bob Hancock from University of British Columbia, Canada, one of the world’s leading experts on antibiotic resistance, discovery and development, as well as Dr Mark Blaskovich (University of Queensland) who runs the open access antimicrobial screening program CO-ADD. There was a commitment from all attendees to collectively work on the development of approaches to combat a particularly problematic area of antibiotic resistance, biofilms. This will hopefully have direct benefits to the continued development of antimicrobial contact lenses and other biomaterials used in optometry.

In 2019 thus far we have published 124 peer reviewed articles. These include eight in British Journal of Ophthalmology, seven in Clinical and Experimental Optometry, six in Investigative Ophthalmology and Visual Science, four in The Ocular Surface, four in Clinical and Experimental Ophthalmology. These articles cover a range of subjects, including the hot and big topics in optometry and vision science, and science and society: Myopia and its control (nine articles), the prevalence of vision problems around the world (eight articles) and antibiotics and resistance (eight articles).

The following 10 papers are some of those that we have been published as open access. We do this so you can review our work – click on the hyperlinks below to read:

  1. Ye B, et al. Discrimination of indoor versus outdoor environmental state with machine learning algorithms in myopia observational studies. J Trans Med 2019; 17: 314.
  2. Ho KC, et al. Systematic review of the appropriateness of eye care delivery in eye care practice. BMC Health Serv Res 2019; 19: 646.
  3. Yasir M, et al.  Comparative mode of action of the antimicrobial peptide melimine and its derivative Mel4 against Pseudomonas aeruginosa. Sci Rep 2019; 9: 7063 
  4. Subedi D, et al. Accessory genome of the multi-drug resistant ocular isolate of Pseudomonas aeruginosa PA34. PLoS ONE. 2019; 14: e0215038.
  5. Naidoo KS, et al., Potential lost productivity resulting from the global burden of myopia. Ophthalmol, 2019; 126: 338–346.
  6. Ho KC, et al.  Can the appropriateness of eye care be measured through cross-sectional retrospective patient record review in eye care practices in Australia? The iCareTrack feasibility study. BMJ Open. 2019; 9: 024298.
  7. Wildsoet CF, et al. IMI – interventions for controlling myopia onset and progression report.  Invest Ophthalmol Vis Sci. 2019; 60: M106-M131.
  8. Flitcroft DI, et al. IMI – defining and classifying myopia: a proposed set of standards for clinical and epidemiologic studies. Invest Ophthalmol Vis Sci 2019; 60:  M20-M30.
  9. Chena AH, et al. Comparison of the pediatric vision screening program in 18 countries across five continents. J Curr Ophthalmol. In Press.
  10. Long J, et al. The pitfalls of the traditional office ergonomics model in the current mobile work environment: Is visual ergonomics health literacy the remedy? Work 2019; 63: 447-456.
Professor Mark Willcox
Director of Research

2018

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Research Highlights

Since out last newsletter we have had some great research outputs from SOVS.

Many of our academics were involved in TFOS DEWS II. This was a global effort that involved 150 clinical and basic research experts from 23 countries. These experts reviewed literature to provide an evidence-based global consensus on multiple aspects of this increasingly common disease. There were 10 subcommittees and a steering committee that were tasked with the overall objectives to (1) Update the definition, classification and diagnosis of Dry Eye Disease, (2) Critically assess the aetiology, mechanism, distribution and impact of this disorder, and (3) Address its management and therapy. This process took just over 2 years of intense effort.

The School had members on the following subcommittees: Steering committee (Fiona Stapleton; Mark Willcox); Definition and Classification (Fiona Stapleton); Sex, Gender, Hormone (Blanka Golebiowski, Mark Willcox); Epidemiology Report (Fiona Stapleton, Isabelle Jalbert); Tear Film (Mark Willcox, Eric Papas – and PhD alumnus Ulrike Stahl); Pain and Sensation(Fiona Stapleton); Pathophysiology (Maria Markoulli); Iatrogenic Dry Eye (Post-doc alumnus Nathan Efron); Clinical Trial Design (Fiona Stapleton). Indeed, the only committees in which SOVS was not directly involved were Diagnostic Methodology and Management and Therapy

groupphoto
Photograph of members of TFOS Board of Directors and Industry Advisory Board who met in Boston in April 2018

The report provides a new definition of  Dry Eye Disease as:

“Dry eye is a multifactorial disease of the ocular surface characterized by a loss of homeostasis of the tear film, and accompanied by ocular symptoms, in which tear film instability and hyperosmolarity, ocular surface inflammation and damage, and neurosensory abnormalities play etiological roles.”

The Sex, Gender, Hormone report highlighted the major role sex, gender and hormones play in the regulation of ocular surface and adnexal tissues, and in the difference in the prevalence of Dry Eye Disease between women and men.

The Epidemiology Report produced estimates for the prevalence of this disease and showed that prevalence increased between 2.0% (self-report of a clinical diagnosis of dry eye) and 10.5% (based on a positive Schirmer test) by decade. The prevalence of meibomian gland disease increased by 5.3% per decade. The differences in the prevalence of Dry Eye Disease between man and women become most obvious after 50 years of age.

The Pathophysiology subcommittee provided a diagram (TFOS DEWS II Pathophysiology, reproduced below with permission from Elsevier) that outlines factors associated with this disease and highlights the vicious cycle that can exacerbate the disease. 

ADDE

The Vicious Circle of Dry Eye Disease” reprinted from The Ocular Surface Vol 15 2017. Bron AJ. et al 

The Tear Film report highlighted ways of measuring tear film stability, made a plea for the development of an instrument to measure tear film evaporation, and showed that new biomarkers (proteins, lipids and mucins) have been discovered that offer improved ways to diagnose the disease, monitor its progress, and measure success of therapies. Dry Eye Disease is associated with ocular pain and dryness sensations.

The Pain and Sensation subcommittee outlined the neuronal basis for this. The report explains that the inflammation associated with Dry Eye Disease causes sensitization of (polymodal and mechano-nociceptor) nerve endings and an abnormal increase in cold thermoreceptor activity, altogether evoking dryness sensations and pain.

The Diagnostic Methodology and Management and Therapy subcommittees produced what I think should be easy to use and valuable schematics to take you through their recommendations – one of these is reproduced here:

 
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“Dry Eye Disease diagnostic test battery” reprinted from The Ocular Surface Vol 15 2017. Wolffsohn JS et al. TFOS DEWS II Diagnostic Methodology report, with permission from Elsevier. 

2017

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Early Career Researchers

Update provided by Professor Mark Willcox.

We have had another great year of research at SOVS. We have published nearly 100 papers this year and there are still some in press. I’d like to highlight a few of these in this report, especially those from our Early Career Researchers.

Dr Jerome Ozkan has a paper published in Scientific Reports (Ozkan J, et al., Temporal stability and composition of the ocular surface microbiome. Scientific Reports 2017; 7(1): 9880). He used non-culture and culture methods in this report, and found a very sparse microbiome on the ocular surface after careful removal of contaminating DNA. He found that there was some taxa that were consistently recovered within individuals suggesting the possibility of individual-specific core microbiomes. This may have implications for protection of the eye, and development of ocular surface abnormalities – and Jerome tells me he’s is looking at these aspects in future research. Figure 1 (Ozkan et al., 2017) shows the commonest bacteria from the ocular surface using DNA sequencing techniques. The most common bacteria were Corynebacterium sp and Acinetobacter sp. (11% overall).

Ozkan

Dr Lakshmi Bodduluri, one of our PhD students who graduated during 2017, published a paper (Bodduluri L, et al., Impact of gamification of vision tests on the user experience. Games for Health Journal 2017; 6(4): 229-236) on the use of gamification theory in vision tests. For those who don’t know (like me – I had to look up this definition) gamification is the application of elements and principals found in gaming, such as incorporation of social/reward aspects, in non-game contexts. Lakshmi found that “over the short term, the careful application of gaming elements to vision tests was found to increase the fun level of users, without affecting engagement with the vision test.” (Figure 2: From Bodduluri et al., 2017. In this picture (c) is a gamified version of a standard vision test, that incorporates aspects of gaming rewards and reinforcement).

Lakshmi

Dr Pauline Kang, a new Lecturer at SOVS and a previous PhD student, published a paper on the effect of multifocal contact lenses on vision in young adults who have been prescribed these to control myopia (Kang P, et al. Effects of multifocal soft contact lenses used to slow myopia progression on quality of vision in young adults. Acta Ophthalmologica 2017; 95(1): e43-e53). She paper describes how these contact lenses can have a significant effect on low-contrast visual acuity and quality of vision, but not on high-contrast visual acuity. The paper recommended that clinicians should educate their patients about  these effect on vision. Figure 3 (Kang et al., 2017) shows how the multifocal (MF) contact lenses affect low contrast visual acuity compared to single vision lenses.

Kang

Conference highlights and grant successes

Not only did we have a great year for outputs such as publications, staff attended many national and international conferences throughout the year to showcase their research. These conferences included the Tear Film and Ocular Surface societies meeting on the Dry Eye Workshop II report (in Sydney in January and Rome in March; (see the tear film website for more information),  Association for Research in Vision and Ophthalmology (Baltimore USA in May), British Contact Lens Association (in Liverpool UK in June), European Academy of Allergy and Clinical Immunology (Helsinki Finland in June), International Society for Contact Lens Research (Stevenson Washington USA in August).

As well as that, we were successful in obtaining funding from the NHMRC to support our research into new antimicrobials – this time looking at their ability to protect bones from becoming infected after fractures. This was in collaboration with our colleagues Professor Naresh Kumar (UNSW Chemistry) and Professor Bill Walsh (Prince of Wales Hospital). Professor Mark Willcox has also been successful in gaining an ARC grant for investigating the synthesis of novel glyoxylamide antimicrobial peptide mimics that have the capacity to disrupt bacterial membranes.

Professor Mark Willcox Awarded 2017 H Barry Collins Research Medal 

Professor Mark Willcox is the recipient of the 2017 H Barry Collin Research Medal. This prestigous medal is "awarded to recognise outstanding contributions to the advancement of knowledge in optics, vision science or clinical optometry by a person who is an Australian citizen or a graduate of an Australian optometry school, or who has done a significant part of his or her research in an Australian institution".

New collaboration: Guangzhou Wlight Visual Health and Research Institute and Zhongshan Ophthalmic Centre, Sun Yat-Sen University

 

Professor Jian Ge and Dr Xiang Chen (from ZOC, Sun Yat-Sen University, Guangzhou), Mr Ziping Chen (from GWHRI, Guangzhou) and representatives from the Chinese Consulate in Sydney visited the School of Optometry and Vision Science in November, 2017. They toured the UNSW Optometry Clinic, the Optics and Radiometry Laboratory, the Torch Innovation Precinct and Materials Science laboratories at UNSW Sydney.  Following numerous discussions about mutual interests in research and education, the visit culminated in the signing of a Memorandum of Understanding where UNSW, GWHRI and ZOC agreed to move forward together in eye health and lighting research.

We thank Dr Daniel Cui (Visiting Fellow at the School), Mr Warwick Dawson (Director of Knowledge Exchange) and Dr Yuan Wang (Project Manager, Torch Innovation Precinct) for facilitating the visit.

The Torch Innovation Precinct (http://www.torch.unsw.edu.au/about-us) at UNSW is intended to foster entrepeneurship, showcasing Chinese and Australian collaboration. This vision was endorsed by Australian Prime Minister Malcolm Turnbull and Chinese Premier Li Keqiang at a special signing ceremony between UNSW and the Ministry of Science & Technology on 14 April 2016.

Group2

[Pictured above, Top panels L to R: Mr Ziping Chen, Prof. Jian Ge, Mr Warwick Dawson, Prof. Fiona Stapleton

Bottom panel L to R: Dr Sieu Khuu, Dr Lisa Asper, Dr Jennifer Long, Emeritus Prof. Stephen Dain, Dr Blanka Golebiowski, Prof. Mark Willcox, Dr Yuan Wang, Mr Warwick Dawson, Prof. Fiona Stapleton, Prof. Jian Ge, Mr Ziping Chen, Consul Yongfeng Hou, Secretary Zixuan Han, Dr Mei Ying Boon, Dr Daniel Cui, Mr Robin Zhang, Dr Xiang Chen.] 

Item Date: 

Thursday, 30 November, 2017

2016

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2016 highlighted another great year in research at the School of Optometry and Vision Science at UNSW Australia. 

Grant success!

Professor Willcox with his collaborators Professor Naresh Kumar (Chemistry, UNSW) and Professor Bill Walsh (Surgical & Orthopaedic Research Laboratories, Prince of Wales Clinical School, UNSW) were successful in obtaining an NHMRC Development grant. This scheme is designed to facilitate translational of research into products. Our grant was funded to determine whether the antimicrobial agents we have developed, Melimine and dihydropyrrolones, can reduce the incidence of infections of bone fractures. The Australian bone graft market is estimated at $70M and growing. Grafts have an infection rate of 4-32% despite meticulous care from well-trained surgeons employing staged management of open wounds. Use of systemic antibiotics and antibiotic-loaded beads locally can reduce infection by 70% - but often there is no sustained delivery, and local antibiotics have been associated with increased culture of drug-resistant bacteria. Adherent bacteria become antibiotic resistant by forming biofilms. The Development Grant will fund testing of innovative antimicrobial/bone combinations to demonstrate safety and efficacy. In other news about these antimicrobials, we are testing Melimine-coated contact lenses in a large scale clinical trial with our collaborators at the LV Prasad Eye Institute, Hyderabad, India. The trial is due to finish in mid-2017 and will determine whether antimicrobial lenses can reduce the incidence of corneal infiltrative events that occur during contact lens wear. We are also testing both of these compounds in collaboration with Cochlear Ltd, to determine whether they can be used in conjunction with their cochlear devices.

News from our Early Career Researchers

We have a strong team of early career researchers at the School. You may not often hear about them – so I thought we’d highlight what some of these have been doing over the past 6-12 months.

Dr Jackie Tan – Senior Research Fellow: Jackie is the manager of our Eye Research Group – the clinical trials arm of the School. She has been busy with clinical trials over the past year, but also made the time to write – and be award (congratulations!) a Innovation Connections grant from the Australian Government. These grants are designed to connect industry to innovation infrastructure. Jackie’s grant (with Prof Fiona Stapleton) is in collaboration with Stiltec who manufacture and supply omega-3 containing products for the relief of dry-eye.

Dr Maria Markoulli – Senior Lecturer: Maria was promoted to Senior Lecturer. Maria obtained a Juvenile Diabetes Research Foundation travel grant. This travel grant supported Maria’s attendance at the Association for Research in Vision and Ophthalmology conference in Seattle (1-5 May 2016) where she presented her team’s work on the biochemical composition of the tear film in diabetes and how this relates to corneal neuropathy. Maria has a new PhD student, Shyam Sunder Tummanapalli, whose will add to this work by focusing on the effect of diabetes of the ocular surface and the tear film. Maria was also invited to attend the Tear Film and Ocular Surface (TFOS) Conference, held in Montpellier, France in Sept 2016, where she presented an update on aspects of the TFOS Contact Lens Discomfort workshop.

Dr Jran Ozkan – NHMRC Fellow: Jran (Jerome) was awarded a prestigious Peter Doherty Biomedical Fellowship from the NHMRC in 2016. His research aims to understand what constitutes the core and transient ocular microbiome (all the different types of microbes inhabiting the ocular surface), how microbial communities change over time and over the eye’s microhabitats (conjunctiva, lids margins, surface cells/crypts), the effect of pharmaceutical agents (including antibiotics) on its composition and how microbial communities change during disease development. He has also recently published a paper from his previous research into the effects of multifocal contact lenses on short-term accommodative adaptation in myopes, which showed that multifocal contact lenses would maintain efficacy during wear as a method to potentially treat myopia progression.

Dr Alex Hui – Lecturer: Over the past year, Dr Hui was invited to contribute a review for the special issue of Optometry and Vision Science on “Revolutionary Uses of Contact Lenses”.  The publication (Hui A, Willcox M. In vivo studies evaluating the use of contact lenses for drug delivery. Optom Vis Sci 2016;93:367-76.) examined the in vivo (animal and human) investigations into the use of contact lenses as a means to delivery drugs and manage ocular diseases, investigations and developments which continue to be investigated today. Alex also presented a poster at the Tear Film and Ocular Surface Society biennial meeting in Montpellier, France on the alternative uses of cyclosporine A other than for dry eye disease. Dr Hui is completing his first supervision  of two 5th year research projects at the School – one examining the effect of fixation target for the repeatability and accuracy of retinoscopy measurements, and the second on the effects of ocular anaesthetics on the ocular surface on patients with diabetes.

Dr Lisa Nivison-Smith – Research Fellow: Lisa has had a very productive year. She was imitated to speak at International Society of Eye Research conference in Tokyo in September 2016 as part of a special session on 'Plasticity of the Retina'. Here, she highlighted her recent work on changes which occur in the inner retina of mice and humans with Retinitis Pigmentosa which could have implications for vision restoration strategies like bionic eye implants. Lisa was also awarded two competitive travel grants this year, one from the CASS foundation to attend ARVO 2016 and one from the Ian Potter Foundation to attend AAO 2016. Some of you may also know Lisa as the organiser of the first SOVS research information night. This was very successful with over 100 undergraduate students attending. Last but not least – Lisa became a Fellow of the American Academy of Optometry.

Dr Pauline Kang – Lecturer: Pauline has been awarded the prestigious 2016 American Optometric Foundation Jill and George Mertz Fellowship. As a part of this fellowship, Pauline is currently at the State University of New York, College of Optometry, collaborating Professor David Troilo and Dr Alexandra Benavente. Research through this fellowship will promote greater understanding of temporal integration of visual signals in visual development.

 

Item Date: 

Friday, 9 December, 2016