Ajay Vijay

Lecturer

 

About Me:

I am a Research Fellow at the School of Optometry and Vision Science, UNSW.  I specialize in ocular microbiology, with particular interests in animals models of corneal infections, development of new therapies for keratitis, contact lens and contact lens disinfecting agents.

Education
PhD in Optometry (University of New South Wales, 2007)
BSc in Optometry (Birla Institute of Technology, 1993)

Research Goals

  • To understand the effects of contact lenses on the defence systems of the eye.
  • Research into contact lens related corneal infection and inflammations using animal models.
  • Development of novel antimicrobial therapies to help combat ocular infections and inflammation.
  • Improving the safety and efficacy of contact lens related products such as multi-purpose disinfecting solutions and contact lens storage devices.

Current Research Projects

  • Development of antimicrobial contact lenses
  • Microbiome of contact lens cases
  • Antibody microarray for detection of dry eye disease

Professional affiliations

Member of the Association for Research in Vision and Ophthalmology

 

Research Groups

Research Topics

  • Contact lens related infection: epidemiology, microbiology and microbial pathogenesis, resistance to antimicrobials
  • Dry eye: contact lens wear, innervation and symptoms, sex hormones
  • Tear film biochemistry, ocular homeostasis and pathology

Publications

Conference Papers
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Shrestha GS; Vijay AK; Stapleton F; Carnt NA, 2019, 'The effect of collection method on tear interleukin-6 levels in healthy individuals: A pilot study', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Vancouver, CANADA, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Vancouver, CANADA, 28 April 2019 - 02 May 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000488800704313&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2019
Vijay AK; Yuan J; Chen L; Willcox M, 2019, 'The Antimicrobial Efficacy of Multipurpose Disinfecting Solutions Against Emerging Pathogens', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Vancouver, CANADA, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Vancouver, CANADA, 28 April 2019 - 02 May 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000488800707107&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2019
Yerramothu P; Vijay AK; Willcox M, 2017, 'Role of NLRP3 inflammasome in bacterial keratitis', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Baltimore, MD, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Baltimore, MD, 07 May 2017 - 11 May 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000432176306193&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2017
Vijay AK; de Jesus NG; Ong J; Willcox MDP, 2017, 'Bacterial transmission to contact lenses following storage case disinfection', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Baltimore, MD, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Baltimore, MD, 07 May 2017 - 11 May 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000432176300071&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2017
Vijay AK; Liu L; Tran CNL; Lam C; Dang JF; Willcox MDP, 2016, 'Efficacy a novel Povidone Iodine based contact lens disinfection system against bacterial biofilm', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Seattle, WA, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Seattle, WA, 01 May 2016 - 05 May 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000394174003282&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2016
Vijay AK; Willcox M, 2013, 'Adhesion of Stenotrophomonas maltophilia, Delftia acidovorans and Achromobacter xylosoxidans to contact lenses', in Formation of biofilms of Stenotrophomonas maltophilia on contact lenses and lens cases, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Manchester, presented at British Contact Lens Association, Manchester, 06 June 2013 - 09 June 2013, http://dx.doi.org/10.1016/j.clae.2013.08.139
2013
Zhu H; Vijay A; Ozkan J; Wu D; Masoudi S; Borazjani R; Willcox M, 2011, 'The influence of lens wear on bacterial adhesion to Silicone Hydrogel Lenses', Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida, USA, presented at Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida, USA, 01 - 05 May 2011
2011
Willcox M; Zhu H; Vijay A; Ozkan J; Wu D; Masoudi S; Borazjani R, 2010, 'Bacterial adhesion to silicone hydrogel lenses', British Contact Lens Association, Birmingham, England, presented at British Contact Lens Association, Birmingham, England, 27 - 30 May 2010
2010
Conference Abstracts
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Yerramothu P; Vijay AK; Willcox M, 2018, 'Macrophage polarization in bacterial keratitis: A link with NLRP3 inflammasome', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Honolulu, HI, Vol. 59, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honolulu, HI, 29 April 2018 - 03 May 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000442932800197&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2018
Vijay AK; Tang A; Pham R; Tan J; Willcox MDP, 2018, 'Transmission of pathogenic bacteria to contact lenses from storage cases', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Honolulu, HI, Vol. 59, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honolulu, HI, 29 April 2018 - 03 May 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000442912505105&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2018
Siddireddy JS; Vijay AK; Tan J; Willcox M, 2018, 'Do the saturation and fatty acid chain length of meibum and tear lipids determine symptoms in contact lens wearers?', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Honolulu, HI, Vol. 59, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honolulu, HI, 29 April 2018 - 03 May 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000442912505061&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2018
Dutta D; Vijay A; Tong J; Luu W; Zhao T; Cheah KB; Willcox MD, 2016, 'Performance of cationic peptide Mel4 as an antimicrobial agent and contact lens coating.', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Seattle, USA, Vol. 57, presented at Performance of cationic peptide Mel4 as an antimicrobial agent and contact lens coating. Association for Research in Vision and Ophthalmology, Seattle, USA, 01 May 2016 - 05 May 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000394174003281&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2016
Conference Presentations
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Subedi D; Vijay A; Rice S; Willcox M, 2017, 'Association between pathogenic factors and antibiotic resistance in Pseudomonas aeruginosa', Vol. 13, presented at BacPath 14, Adelaide, 25 September 2017 - 28 September 2017, http://dx.doi.org/10.1371/journal.pone.0204936
2017
Journal articles
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Subedi D; Kohli GS; Vijay AK; Willcox M; Rice SA, 2019, 'Accessory genome of the multi-drug resistant ocular isolate of Pseudomonas aeruginosa PA34', PLoS ONE, vol. 14, pp. e0215038, http://dx.doi.org/10.1371/journal.pone.0215038
2019
Vijay AK; Zhu H; Willcox M; Ketelson H; Stapleton F, 2019, 'Bacterial biofilm in silver-impregnated contact lens cases', Contact Lens and Anterior Eye, http://dx.doi.org/10.1016/j.clae.2019.11.004
2019
Subedi D; Kohli GS; Vijay AK; Willcox M; Rice SA, 2019, 'Accessory genome of the multi-drug resistant ocular isolate of Pseudomonas aeruginosa PA34', PLoS ONE, vol. 14,
2019
Siddireddy JS; Tan J; Vijay AK; Willcox MD P, 2019, 'The Effect of Microblepharon Exfoliation on Clinical Correlates of Contact Lens Discomfort', Optometry and Vision Science, vol. 96, pp. 187 - 199,
2019
Subedi D; Vijay AK; Rice SA; Willcox M, 2019, 'Cytotoxic factor influencing acquired antimicrobial resistance in Pseudomonas aeruginosa', Microbiology Australia, vol. 40, pp. 161 - 164, http://dx.doi.org/10.1071/MA19048
2019
Vijay AK; Willcox MDP, 2018, 'Adhesion of Stenotrophomonas maltophilia, Delftia acidovorans, and Achromobacter xylosoxidans to Contact Lenses', Eye & contact lens, vol. 44, pp. S120 - S126, http://dx.doi.org/10.1097/ICL.0000000000000425
2018
Subedi D; Vijay AK; Kohli GS; Rice SA; Willcox M, 2018, 'Comparative genomics of clinical strains of Pseudomonas aeruginosa strains isolated from different geographic sites', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-34020-7
2018
Subedi D; Vijay AK; Kohli GS; Rice SA; Willcox M, 2018, 'Nucleotide sequence analysis of NPS-1 β-lactamase and a novel integron (In1427)-carrying transposon in an MDR Pseudomonas aeruginosa keratitis strain', Journal of Antimicrobial Chemotherapy, vol. 73, pp. 1724 - 1726, http://dx.doi.org/10.1093/jac/dky073
2018
Siddireddy JS; Tan J; Vijay AK; Willcox M, 2018, 'Predictive Potential of Eyelids and Tear Film in Determining Symptoms in Contact Lens Wearers', Optometry and Vision Science, vol. 95, pp. 1035 - 1045, http://dx.doi.org/10.1097/opx.0000000000001290
2018
Siddireddy JS; Tan J; Vijay AK; Willcox M, 2018, 'Predictive Potential of Eyelids and Tear Film in Determining Symptoms in Contact Lens Wearers', Optometry and Vision Science, vol. 95, pp. 1035 - 1045,
2018
Yerramothu P; Vijay AK; Willcox MDP, 2018, 'Inflammasomes, the eye and anti-inflammasome therapy', Eye (Basingstoke), vol. 32, pp. 491 - 505, http://dx.doi.org/10.1038/eye.2017.241
2018
Subedi D; Vijay AK; Willcox M, 2018, 'Overview of mechanisms of antibiotic resistance in Pseudomonas aeruginosa: an ocular perspective', Clinical and Experimental Optometry, vol. 101, pp. 162 - 171, http://dx.doi.org/10.1111/cxo.12621
2018
Siddireddy JS; Vijay AK; Tan J; Willcox M, 2018, 'The eyelids and tear film in contact lens discomfort', Contact Lens & Anterior Eye, vol. 41, pp. 144 - 153, http://dx.doi.org/10.1016/j.clae.2017.10.004
2018
Vijay AK; Willcox M; Zhu H; Stapleton F, 2015, 'Contact lens storage case hygiene practice and storage case contamination', Eye and Contact Lens, vol. 41, pp. 91 - 97, http://dx.doi.org/10.1097/ICL.0000000000000070
2015
Vijay AK; Bandara BM; Zhu H; Willcox MD, 2013, 'Protamine as a potential amoebicidal agent for contact lens disinfection', Optometry and Vision Science, vol. 90, pp. 119 - 124, http://dx.doi.org/10.1097/OPX.0b013e31827cdabc
2013
Vijay AK; Zhu H; Ozkan J; Wu D; Masoudi S; Bandara R; Borazjani R; Willcox MD, 2012, 'Bacterial adhesion to unworn and worn silicone hydrogel lenses', Optometry and Vision Science, vol. 89, pp. 1095 - 1106, http://dx.doi.org/10.1097/OPX.0b013e318264f4dc
2012
Wilcox MDP; Zhu H; Vijay AK, 2012, 'Effect of a warming device on contact lens case contamination', Eye and Contact Lens, vol. 38, pp. 394 - 399, http://dx.doi.org/10.1097/ICL.0b013e318261aa13
2012
Zhu H; Bandara M; Vijay A; Masoudi S; Wu DL; Willcox MD, 2011, 'Importance of rub and rinse in use of multipurpose contact lens solution', Optometry and Vision Science, vol. 88, pp. 967 - 972, http://dx.doi.org/10.1097/OPX.0b013e31821bf976
2011
Cole NA; Hume EB; Vijay AK; Sankaridurg P; Kumar N; Willcox MD, 2010, 'In vivo performance of melimine as an antimicrobial coating for contact lenses in models of CLARE and CLPU', Investigative Ophthalmology and Visual Science, vol. 51, pp. 390 - 395, http://dx.doi.org/10.1167/iovs.09-4068
2010
Willcox MD; Hume EB; Vijay AK; Petvac R, 2010, 'Ability of silver-impregnated contact lenses to control microbial growth and colonisation', Journal of Optometry, vol. 3, pp. 143 - 148, http://dx.doi.org/10.1016/S1888-4296(10)70020-0
2010
Kumar A; Sankaridurg P; Willcox MD, 2009, 'Guinea pig models of acute keratitis responses', Cornea, vol. 28, pp. 1153 - 1159
2009
Garrett Q; Xu S; Simmons P; Vehige J; Xie RZ; Kumar A; Flanagan JL; Zhao Z; Willcox MD, 2008, 'Carboxymethyl cellulose stimulates rabbit corneal epithelial wound healing', Current Eye Research, vol. 33, pp. 567 - 573, http://dx.doi.org/10.1080/02713680802140213
2008