Barbara Zangerl

Senior Lecturer

I have investigated various aspects of inherited and complex eye disorders ranging from the molecular basis and disease pathogenesis to the development of therapy and  improvement of clinical diagnosis. Ongoing projects are focused on understanding the development and changes of sensory systems, specifically the visual system over time and with disease, and consolidated this knowledge to develop optimising eye health care service models.

My continuing research interests largely revolve around chronic, progressive disorders, foremost glaucoma and diabetic retinopathy, as these are major concerns in our society. Current investigations firstly aim to identify new clinical markers to enable early detection and intervention for these conditions. My second, equally important research goal emphasises the implementation of such knowledge in the form of improved technology, assessment or interpretation of clinical data within ophthalmic professions as well as collaborative care models.

 

Education

Dr.med.vet. (equivalent PhD in Genetics; University of Veterinary Medicine Vienna, 1999)

MVM (equivalent DVM, University of Veterinary Medicine Vienna, 1996)

MN, University of Sydney, 2018

 

RESEARCH

Current Student Projects (PhD and undergrad)

How many ganglion cells respond to a visual field stimulus?

How does retinal eccentricity drive the structure-visual function relationship?

Segmenting the Structure-Function Dilemma in Glaucoma

Systematic glaucoma screening and diagnostic effectiveness: improving patient outcomes through early detection

Identification of clinical predictors for conversion and progression of glaucoma

Evaluation of novel collaborative care models

Identification of clinical predictors for diabetes related risk, progression, and complications

Integration of new techniques, such as virtual reality, to improve functional vision assessments

Optomisation of eye health care delivery in Australia

 

TEACHING & OUTREACH

Courses I serve as supervisor on

OPTM5171: Research project 5A (http://www.handbook.unsw.edu.au/undergraduate/courses/2014/OPTM5171.html)

OPTM5271: Research project 5B (http://www.handbook.unsw.edu.au/undergraduate/courses/2014/OPTM5271.html)

OPTM7108: Research skills in Optometry (http://www.handbook.unsw.edu.au/postgraduate/courses/2013/OPTM7108.html)

 

Professional affiliations

Member of the Australian College of Nursing

Member of the Imaging and Perimetry Society

Member of the Beta Chapter of the Society of Phi Zeta at UPenn

Member of The International Society of Animal Genetics (ISAG)

Member of The Association of Research in Vision and Ophthalmology

Member of the European Molecular Biology Organization

 

AWARDS & ACHIEVEMENTS

Honors student scholarship, University Of Veterinary Medicine Vienna, 1992

Honors student scholarship, University Of Veterinary Medicine Vienna, 1993

Honors student scholarship, University Of Veterinary Medicine Vienna, 1994

Young scholar presentation award, 28th International Conference on Animal Genetics, Göttingen, Germany, 2002

Publications

Conference Papers
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Huang J; Kalloniatis M; Katalinic P; Zangerl B, 2017, 'IOP Fluctuations in glaucoma patients measured by a self-administered tonometer', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Baltimore, MD, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Baltimore, MD, 07 May 2017 - 11 May 2017,
2017
Guziewicz K; Komaromy A; Iwabe S; Cideciyan A; Dutrow E; Zangerl B; Beltran W; Jacobson S; Hauswirth W; Aguirre G, 2013, 'Sustained Therapeutic Reversal of Canine Bestrophinopathy with Gene Therapy using Recombinant AAV2', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC,
2013
Zangerl B; Wong E; Yoshioka N; Hennessy M; Kalloniatis M, 2013, 'The optic nerve head: does size matter?', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC,
2013
Guziewicz KE; Komaromy AM; Hauswirth WW; Boye SL; Chiodo VA; Slavik J; Acland GM; Aguirre GD; Zangerl B, 2010, 'Targeting Gene Expression to the RPE With AAV2/1 and AAV2/2 Vectors', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC,
2010
Genini S; Beltran WA; Zangerl B; Aguirre GD, 2010, 'Up-Regulation of Expression of Genes Belonging to the Tumor Necrosis Factor (TNF) Superfamily in RPGR-ORF15 Frameshift Mutant Retina', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC,
2010
Zangerl B; Cideciyan AV; Aleman TS; Jacobson SG; Guziewicz KE; Acland GM; Aguirre GD; Beltran WA, 2010, 'Canine Multifocal Retinopathy (cmr1) Model of Human Best Macular Dystrophy: Imaging Earliest Retinal Lesions', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC,
2010
Paez GL; Zangerl B; Sellers K; Acland GM; Aguirre GD, 2008, 'Characterization of gene expression profiles of normal canine retina and brain using a retinal cDNA microarray', in Advances in Experimental Medicine and Biology, pp. 179 - 184,
2008
Hunter LS; Sidjanin D; Johnson J; Zangerl B; Galibert F; Andre C; Talamas E; Acland G; Aguirre G, 2005, 'Mapping and evaluation of cataract candidate genes in canine models', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Ft Lauderdale, FL, presented at Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO 2005), Ft Lauderdale, FL, 01 May 2005 - 05 May 2005,
2005
Zangerl B; Lindauer SJ; Acland GM; Aguirre GD, 2005, 'Polymorphism and association study to identify a canine model for retinal disorders caused by ABCA4', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Ft Lauderdale, FL, presented at Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO 2005), Ft Lauderdale, FL, 01 May 2005 - 05 May 2005,
2005
Paez GL; Zangerl B; Acland GM; Aguirre GD, 2005, 'Comparison of gene expression profiles in normal retina and brain using a canine retinal cDNA microarray', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Ft Lauderdale, FL, presented at Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO 2005), Ft Lauderdale, FL, 01 May 2005 - 05 May 2005,
2005
Zangerl B; Johnson JL; Hernandez AG; Galibert F; Andre C; Pillardy J; Sun Q; Acland GM; Aguirre GD, 2004, 'Identification of candidate retinal degeneration genes by genome wide EST mapping', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Ft Lauderdale, FL, pp. U320 - U320, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Ft Lauderdale, FL, 24 April 2004 - 29 April 2004,
2004
Paez GL; Zangerl B; Acland GM; Aguirre GD, 2004, 'Microarray analysis of gene expression in retinas of normal versus XLPRA1 and XLPRA2 affected dogs', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Ft Lauderdale, FL, pp. U319 - U319, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Ft Lauderdale, FL, 24 April 2004 - 29 April 2004,
2004
Zangerl B; Pillardy J; Miller B; Sun Q; Johnson J; Schweitzer P; Hernandez AG; Liu L; Acland GM; Aguirre GD, 2003, 'Development of a normalized canine retinal cDNA library for microarray analysis and characterization of 10,000 ESTs', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, FT LAUDERDALE, FLORIDA, pp. U387 - U387, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, FT LAUDERDALE, FLORIDA, 01 May 2003,
2003
Zangerl B; Zhang Q; Johnson J; Acland G; Aguirre G; Baker JA, 2002, 'Independent origin of three microdeletions in RPGR exon ORF15 of canids', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, FT LAUDERDALE, FLORIDA, pp. U1019 - U1019, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, FT LAUDERDALE, FLORIDA, 05 May 2002 - 10 May 2002,
2002
Zangerl B; Zhang Q; Aguirre G, 2001, 'Canine Glucocorticoid Receptor Promoter Binding Protein (GRF1): a transcription factor potentially involved in the prcd pathology.', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, pp. S769 - S769,
2001
Journal articles
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Quek KJ; Boyd R; Ameer OZ; Zangerl B; Butlin M; Murphy TV; Avolio AP; Phillips JK, 2016, 'Progressive vascular remodelling, endothelial dysfunction and stiffness in mesenteric resistance arteries in a rodent model of chronic kidney disease', Vascular Pharmacology, vol. 81, pp. 42 - 52,
2016
Guziewicz K; Beltran W; Cideciyan A; Komaromy A; Iwabe S; Dutrow E; Zangerl B; Hauswirth W; Jacobson S; Aguirre G, 2014, 'Gene therapy for bestrophinopathies', ACTA OPHTHALMOLOGICA, vol. 92,
2014
Guziewicz KE; Zangerl B; Komáromy AM; Iwabe S; Chiodo VA; Boye SL; Hauswirth WW; Beltran WA; Aguirre GD, 2013, 'Recombinant AAV-Mediated BEST1 Transfer to the Retinal Pigment Epithelium: Analysis of Serotype-Dependent Retinal Effects', PLoS ONE, vol. 8,
2013
Guziewicz KE; Aguirre GD; Zangerl B, 2012, 'Modeling the structural consequences of BEST1 missense mutations', Advances in Experimental Medicine and Biology, vol. 723, pp. 611 - 618,
2012
Kuznetsova T; Zangerl B; Aguirre GD, 2012, 'RPGRIP1 and cone-rod dystrophy in dogs', Advances in Experimental Medicine and Biology, vol. 723, pp. 321 - 328,
2012
Hoffmann I; Guziewicz KE; Zangerl B; Aguirre GD; Mardin CY, 2012, 'Canine multifocal retinopathy in the Australian Shepherd: A case report', Veterinary Ophthalmology, vol. 15, pp. 134 - 138,
2012
Wang P; Zangerl B; Werner P; Mauldin EA; Casal ML, 2011, 'Familial cutaneous lupus erythematosus (CLE) in the German shorthaired pointer maps to CFA18, a canine orthologue to human CLE', Immunogenetics, vol. 63, pp. 197 - 207,
2011
Kuznetsova T; Zangerl B; Goldstein O; Acland GM; Aguirre GD, 2011, 'Structural organization and expression pattern of the canine RPGRIP1 isoforms in retinal tissue', Investigative Ophthalmology and Visual Science, vol. 52, pp. 2989 - 2998,
2011
Guziewicz KE; Slavik J; Lindauer SJ P; Aguirre GD; Zangerl B, 2011, 'Molecular consequences of BEST1 gene mutations in canine multifocal retinopathy predict functional implications for human bestrophinopathies', Investigative Ophthalmology and Visual Science, vol. 52, pp. 4497 - 4505,
2011
Zanger B; Lindauer SJ; Acland GM; Aguirre GD, 2010, 'Identification of genetic variation and haplotype structure of the canine ABCA4 gene for retinal disease association studies', Molecular Genetics and Genomics, vol. 284, pp. 243 - 250,
2010
Genini S; Zangerl B; Slavik J; Acland GM; Beltran WA; Aguirre GD, 2010, 'Transcriptional profile analysis of RPGRORF15 frameshift mutation identifies novel genes associated with retinal degeneration', Investigative Ophthalmology and Visual Science, vol. 51, pp. 6038 - 6050,
2010
Zangerl B; Wickström K; Slavik J; Lindauer SJ; Ahonen S; Schelling C; Lohi H; Guziewicz KE; Aguirre GD, 2010, 'Assessment of canine BEST1 variations identifies new mutations and establishes an independent bestrophinopathy model (cmr3)', Molecular Vision, vol. 16, pp. 2791 - 2804
2010
Zangerl B; Johnson JL; Pillardy J; Sun Q; André C; Galibert F; Acland GM; Aguirre GD, 2009, 'Comparative genomic mapping of uncharacterized canine retinal ESTs to identify novel candidate genes for hereditary retinal disorders', Molecular Vision, vol. 15, pp. 927 - 936
2009
Guziewicz KE; Zangerl B; Lindauer SJ; Mullins RF; Sandmeyer LS; Grahn BH; Stone EM; Acland GM; Aguirre GD, 2007, 'Bestrophin gene mutations cause canine multifocal retinopathy: A novel animal model for best disease', Investigative Ophthalmology and Visual Science, vol. 48, pp. 1959 - 1967,
2007
Zangerl B; Johnson JL; Acland GM; Aguirre GD, 2007, 'Independent origin and restricted distribution of RPGR deletions causing XLPRA', Journal of Heredity, vol. 98, pp. 526 - 530,
2007
Hunter LS; Sidjanin DJ; Johnson JL; Zangerl B; Galibert F; Andre C; Kirkness E; Talamas E; Acland GM; Aguirre GD, 2006, 'Radiation hybrid mapping of cataract genes in the dog', Molecular Vision, vol. 12, pp. 588 - 596
2006
Zangerl B; Sun Q; Pillardy J; Johnson JL; Schweitzer PA; Hernandez AG; Liu L; Acland GM; Aguirre GD, 2006, 'Development and characterization of a normalized canine retinal cDNA library for genomic and expression studies', Investigative Ophthalmology and Visual Science, vol. 47, pp. 2632 - 2638,
2006
Paez GL; Sellers KF; Band M; Acland GM; Zangerl B; Aguirre GD, 2006, 'Characterization of gene expression profiles of normal canine retina and brain using a retinal cDNA microarray', Molecular Vision, vol. 12, pp. 1048 - 1056
2006
Goldstein O; Zangerl B; Pearce-Kelling S; Sidjanin DJ; Kijas JW; Felix J; Acland GM; Aguirre GD, 2006, 'Linkage disequilibrium mapping in domestic dog breeds narrows the progressive rod-cone degeneration interval and identifies ancestral disease-transmitting chromosome', Genomics, vol. 88, pp. 541 - 550,
2006
Zangerl B; Goldstein O; Philp AR; Lindauer SJ P; Pearce-Kelling SE; Mullins RF; Graphodatsky AS; Ripoll D; Felix JS; Stone EM; Acland GM; Aguirre GD, 2006, 'Identical mutation in a novel retinal gene causes progressive rod-cone degeneration in dogs and retinitis pigmentosa in humans', Genomics, vol. 88, pp. 551 - 563,
2006
Kijas JW; Zangerl B; Miller B; Nelson J; Kirkness EF; Aguirre GD; Acland GM, 2004, 'Cloning of the canine ABCA4 gene and evaluation in canine cone-rod dystrophies and progressive retinal atrophies', Molecular Vision, vol. 10, pp. 223 - 232
2004
Kauer M; Zangerl B; Dieringer D; Schlötterer C, 2002, 'Chromosomal patterns of microsatellite variability contrast sharply in African and non-African populations of Drosophila melanogaster', Genetics, vol. 160, pp. 247 - 256
2002
Sidjanin DJ; Zangerl B; Johnson JL; Xue F; Mellersh C; Ostrander EA; Acland G; Aguirre GD, 2002, 'Cloning of the canine delta tubulin cDNA (TUBD) and mapping to CFA9', Animal Genetics, vol. 33, pp. 161 - 162,
2002
Zangerl B; Zhang Q; Acland GM; Aguirre GD, 2002, 'Characterization of three microsatellite loci linked to the canine RP3 interval', Journal of Heredity, vol. 93, pp. 70 - 73
2002
Zangerl B; Zhang Q; Pearce-Kelling SE; Aguirre GD, 2002, 'Molecular cloning, characterization and mapping of the canine glucocorticoid receptor DNA binding factor 1 (GRLF1)', Gene, vol. 294, pp. 167 - 176,
2002
Akhmedov NB; Baldwin VJ; Zangerl B; Kijas JW; Hunter L; Minoofar KD; Mellersh C; Ostrander EA; Acland GM; Farber DB; Aguirre GD, 2002, 'Cloning and characterization of the canine photoreceptor specific cone-rod homeobox (CRX) gene and evaluation as a candidate for early onset photoreceptor diseases in the dog', Molecular Vision, vol. 8, pp. 79 - 84
2002
Zhang Q; Acland GM; Zangerl B; Johnson JL; Mao Z; Zeiss CJ; Ostrander EA; Aguirre GD, 2001, 'Fine mapping of canine XLPRA establishes homology of the human and canine RP3 intervals', Investigative Ophthalmology and Visual Science, vol. 42, pp. 2466 - 2471
2001
Harr B; Zangerl B; Schlötterer C, 2000, 'Removal of microsatellite interruptions by DNA replication slippage: Phylogenetic evidence from Drosophila', Molecular Biology and Evolution, vol. 17, pp. 1001 - 1009,
2000
Bachtrog D; Weiss S; Zangerl B; Brem G; Schlötterer C, 1999, 'Distribution of dinucleotide microsatellites in the Drosophila melanogaster genome', Molecular Biology and Evolution, vol. 16, pp. 602 - 610,
1999
Harr B; Zangerl B; Brem G; Schlötterer C, 1998, 'Conservation of locus-specific microsatellite variability across species: A comparison of two Drosophila sibling species, D. melanogaster and D. simulans', Molecular Biology and Evolution, vol. 15, pp. 176 - 184,
1998