Research Title: Development of an eye model to screen optical interventions for their ability to slow myopia progression
Supervisors: Associate Professor Klaus Ehrmann, Professor Padmaja Sankaridurg, Dr Fabian Conrad
Title of the project: Development of an eye model to screen optical interventions for their ability to control myopia progression
Background: Increasing levels of myopia are associated with increased risk of developing visual impairment and blinding complications. To reduce the burden associated with myopia, various interventions to retard the progression of myopia in children have been tried. Some of these interventions show promise and studies are underway to improve the efficacy obtained from these interventions. However, these interventions require long term and expensive clinical studies and therefore limit the ability to measure the efficacy of various interventions. Previous studies have found choroidal thickness to change in response to optical defocus and therefore provide an avenue to screen and select optical interventions based on their ability to elicit the appropriate ocular response prior to conducting long-term clinical studies with such interventions. However, previous studies were mostly confined to central retina and limited to studying choroidal response.
Rationale: It would be highly desirable to be able to screen optical interventions for their ability to elicit the appropriate ocular response over a short period. Candidate interventions that pass the screening test could be further evaluated in long-term clinical trials thus minimising the risk of negative result in a long-term clinical trial.
- To determine changes if any in eye length and choroidal thickness at central retina and at various locations along the peripheral retina in response to optical defocus; and
- To develop an eye model based on central and/or peripheral eye length and choroidal thickness that can be used to predict the effect of optical interventions for control of myopia.
-No Changes in central and peripheral eye length and choroidal thickness can be measured in response to optical defocus.
-An eye model can be developed to predict the effect of optical interventions for controlling myopia progression.
Experimental designs and methods: Central and peripheral eye length and choroidal thickness of will be measured in response to optical interventions, and results will help develop the model. Once the model is validated, novel myopia control agents could be tested.
Ornella graduated from Bausch and Lomb School of Optometry, India in 2013. She then return to her home country (Cameroon) and joined the teaching team of a training school in Yaounde as an Optometrist Lecturer. She is currently pursuing her PhD at the UNSW School of Optometry and Vision Science and her research area is myopia.
2016 - PhD, UNSW Sydney, Australia
2009 - 2013 Bachelor of Science in Optometry, Bausch & Lomb School of Optometry, India
- Peripheral eye length measurement techniques: a review. (https://doi.org/10.1111/cxo.12892)
- Paper review on Review of myopia management (https://reviewofmm.com/global-variations-and-time-trends-in-the-prevalence-of-childhood-myopia-a-systematic-review-and-quantitative-meta-analysis-implications-for-aetiology-and-early-prevention/)
The International Society for Contact Lens Research (ISCLR) Student Grant
The Postgraduate Research Student Support (PRSS) Scholarship, University of New South Wales
Tuition Fees Scholarship for PhD, University of New South Wales and The Brien Holden Vision Institute
The Association for Research in Vision and Ophthalmology (ARVO) 2019
Poster presentation (Effects of short-term imposed optical defocus on central and peripheral eye length, choroidal thickness and accommodative responses in young healthy subjects)
The International Society for Contact Lens Research (ISCLR) 2019
Paper and Poster presentation (Time of the day and influence of optical defocus on eye length and choroidal thickness)
AFFILIATIONS AND MEMBERSHIPS
Member, International Society for Contact Lens Research
Member, Association for Research in Vision and Ophthalmology
Member, Women in Math and Science Champion team, University of New South Wales
Cameroon Association of Optometrists