Lisa Nivison-Smith

Senior Research Associate

 

ABOUT ME:

My research interests lie in the fundamental biology of the healthy and diseased retina. I specifically focus on anatomical and neurochemical modifications which occur in the early stages of disease prior to permanent vision loss. I study retinal neurobiology in two ways: (1) I use clinical approach, assessing data obtained from patients attending the Centre For Eye Health on the UNSW campus and (2) I use a basic science approach, assessing rodent models of retinal disease at different stages. This research is highly significant as it focuses on early disease, allowing us to potentially determine the underlying mechanism/s of disease. In addition, many interventions for blinding diseases such as the bionic eye or stem cell transplantation, depend on accurate knowledge of the retinal architecture in retinal disease. This research can provide these modified anatomical and functional roadmaps of the diseased retina as well as discover new intervention points for new therapeutics. 

For further information on my research, please visit the Retinal Networks Laboratory or my Facebook page  

 

BASIC SCIENCE RESEARCH

My basic science research involves

  • animal models of inherited retinal dystrophies (rd1 mouse, P23H rat),
  • carriers of retinal dystrophies (heterozygous rd1 mouse)
  • animal models for retinal metabolic conditions (ischaemia model via elevated IOP).
  • a range of techniques to assess the retina including histology, immunocytochemistry, microscopy, rodent electroretinography (ERG), metabolic assays and glutamate receptor functional mapping

Current basic science student projects

CLINICAL RESEARCH

My clinical research involves
  • investigating major retinal diseases which cause blindness such as age-related macular degeneration (AMD) and Retinitis Pigmentosa
  • performing image analysis from a range of advanced modalities including optical coherence tomography (OCT), multi-spectral imaging, fundus autofluorscence, infra-red imaging and ultra wide field imaging
  • assessing pathological retinal function using psychophyiscal tests and electrophysiology

 

 Current clinical student projects

 

     

       

       

      Publications

      Conference Papers
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      Nivison-Smith L; Zhang C; de Souza C; Michael K; Charles M; Philip P; Angus G; Monica A, 2015, 'Water channel permeability in retinal degeneration. the role of aquaporins', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Cairns, AUSTRALIA, pp. 374 - 374, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, AUSTRALIA, 23 August 2015 - 27 August 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300962&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
      2015
      Journal articles
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      Trinh M; Kalloniatis M; Nivison-Smith L, 2019, 'Vascular changes in intermediate age-related macular degeneration quantified using optical coherence tomography angiography', Translational Vision Science and Technology, vol. 8, http://dx.doi.org/10.1167/tvst.8.4.20
      2019
      Nivison-Smith L; Milston R; Chiang J; Ly A; Assaad N; Kalloniatis M, 2018, 'Peripheral retinal findings in populations with macular disease are similar to healthy eyes', Ophthalmic and Physiological Optics, vol. 38, pp. 584 - 595,
      2018
      Nivison-Smith L; Khoo P; Acosta ML; Kalloniatis M, 2018, 'Vinpocetine protects inner retinal neurons with functional NMDA glutamate receptors against retinal ischemia', Experimental Eye Research, vol. 167, pp. 1 - 13, http://dx.doi.org/10.1016/j.exer.2017.10.008
      2018
      Chiang J; Katalinic P; Nivison-Smith L; Yapp M; Khuu S; Watt K; Kalloniatis M, 2017, 'Teaching ocular imaging, disease diagnosis​ and management within a work-integrated setting: a novel model within an optometric education program', Journal of Optometric Education
      2017
      Nivison-Smith L; Khoo P; Acosta ML; Kalloniatis M, 2017, 'Pre-treatment with vinpocetine protects against retinal ischemia', Experimental Eye Research, vol. 154, pp. 126 - 138, http://dx.doi.org/10.1016/j.exer.2016.11.018
      2017
      Ly A; Nivison-Smith L; Hennessy M; Kalloniatis M, 2017, 'The advantages of intermediate-tier, inter-optometric referral of low risk pigmented lesions', Ophthalmic and Physiological Optics, vol. 37, pp. 661 - 668, http://dx.doi.org/10.1111/opo.12413
      2017
      Ly A; Nivison-Smith L; Hennessy MP; Kalloniatis M, 2016, 'Collaborative care of non-urgent macular disease: a study of inter-optometric referrals', Ophthalmic and Physiological Optics, vol. 36, pp. 632 - 642, http://dx.doi.org/10.1111/opo.12322
      2016
      Nivison-Smith L; Obrien BJ; Truong M; Guo CX; Kalloniatis M; Acosta ML, 2015, 'Vinpocetine modulates metabolic activity and function during retinal ischemia', American Journal of Physiology - Cell Physiology, vol. 308, pp. C737 - C749, http://dx.doi.org/10.1152/ajpcell.00291.2014
      2015
      Wong E; Nivison-Smith L; Assaad NN; Kalloniatis M, 2015, 'OCT and fundus autofluorescence enhances visualization of white dot syndromes', Optometry and Vision Science, vol. 92, pp. 642 - 653, http://dx.doi.org/10.1097/OPX.0000000000000572
      2015
      Nivison-Smith L; Acosta ML; Misra S; O'Brien BJ; Kalloniatis M, 2014, 'Vinpocetine regulates cation channel permeability of inner retinal neurons in the ischaemic retina', Neurochemistry International, vol. 66, pp. 1 - 14, http://dx.doi.org/10.1016/j.neuint.2014.01.003
      2014
      Nivison-Smith L; Chua J; Tan SS; Kalloniatis M, 2014, 'Amino acid signatures in the developing mouse retina', International Journal of Developmental Neuroscience, vol. 33, pp. 62 - 80, http://dx.doi.org/10.1016/j.ijdevneu.2013.12.005
      2014
      Chua J; Nivison-Smith L; Tan SS; Kalloniatis M, 2013, 'Metabolic profiling of the mouse retina using amino acid signatures: Insight into developmental cell dispersion patterns', Experimental Neurology, vol. 250, pp. 74 - 93, http://dx.doi.org/10.1016/j.expneurol.2013.09.007
      2013
      Chua J; Nivison-Smith L; Fletcher EL; Trenholm S; Awatramani G; Kalloniatis M, 2013, 'Early remodeling of Müller cells in the rd/rd mouse model of retinal dystrophy', Journal of Comparative Neurology, vol. 521, pp. 2439 - 2453, http://dx.doi.org/10.1002/cne.23307
      2013
      Nivison-Smith L; Sun D; Fletcher EL; Marc R; Kalloniatis M, 2013, 'Mapping kainate activation of inner neurons in the rat retina', Journal of Comparative Neurology, vol. 521, pp. 2416 - 2438, http://dx.doi.org/10.1002/cne.23305
      2013
      Nivison-Smith L; Collin SP; Zhu Y; Ready S; Acosta ML; Hunt DM; Potter IC; Kalloniatis M, 2013, 'Correction: Retinal Amino Acid Neurochemistry of the Southern Hemisphere Lamprey,.', PloS one, vol. 8, http://dx.doi.org/10.1371/annotation/99baec7f-908c-4e88-8a87-a25f2aa1630c
      2013
      Nivison-Smith L; Weiss AS, 2012, 'Alignment of human vascular smooth muscle cells on parallel electrospun synthetic elastin fibers', Journal of Biomedical Materials Research - Part A, vol. 100 A, pp. 155 - 161, http://dx.doi.org/10.1002/jbm.a.33255
      2012
      Nivison-Smith L; Rnjak J; Weiss AS, 2010, 'Synthetic human elastin microfibers: Stable cross-linked tropoelastin and cell interactive constructs for tissue engineering applications', Acta Biomaterialia, vol. 6, pp. 354 - 359, http://dx.doi.org/10.1016/j.actbio.2009.08.011
      2010
      Grant A; Trompf K; Seung D; Nivison-Smith L; Bowcock H; Kresse H; Holmes S; Radford J; Morrow P, 2010, 'Sub-cellular damage by copper in the cnidarian Zoanthus robustus', Comparative Biochemistry and Physiology - C Toxicology and Pharmacology, vol. 152, pp. 256 - 262, http://dx.doi.org/10.1016/j.cbpc.2010.04.013
      2010
      Almine JF; Bax DV; Mithieux SM; Nivison-Smith L; Rnjak J; Waterhouse A; Wise SG; Weiss AS, 2010, 'Elastin-based materials', Chemical Society Reviews, vol. 39, pp. 3371 - 3379, http://dx.doi.org/10.1039/b919452p
      2010
      Almine JF; Bax DV; Mithieux SM; Nivison-Smith L; Rnjak J; Waterhouse A; Wise SG; Weiss AS, 2010, 'ChemInform Abstract: Elastin-Based Materials', ChemInform, vol. 41, pp. no - no, http://dx.doi.org/10.1002/chin.201051252
      2010