Lisa Nivison-Smith

Scientia Fellow (Level B)

 

ABOUT ME:

My research interests lie in the fundamental biology of the healthy and diseased retina. I specifically focus on anatomical and neurochemical modifications which occur in the early stages of disease prior to permanent vision loss. I study retinal neurobiology in two ways: (1) I use clinical approach, assessing data obtained from patients attending the Centre For Eye Health on the UNSW campus and (2) I use a basic science approach, assessing rodent models of retinal disease at different stages. This research is highly significant as it focuses on early disease, allowing us to potentially determine the underlying mechanism/s of disease. In addition, many interventions for blinding diseases such as the bionic eye or stem cell transplantation, depend on accurate knowledge of the retinal architecture in retinal disease. This research can provide these modified anatomical and functional roadmaps of the diseased retina as well as discover new intervention points for new therapeutics. 

For further information on my research, please visit the Retinal Networks Laboratory or my Facebook page  

 

BASIC SCIENCE RESEARCH

My basic science research involves

  • animal models of inherited retinal dystrophies (rd1 mouse, P23H rat),
  • carriers of retinal dystrophies (heterozygous rd1 mouse)
  • animal models for retinal metabolic conditions (ischaemia model via elevated IOP).
  • a range of techniques to assess the retina including histology, immunocytochemistry, microscopy, rodent electroretinography (ERG), metabolic assays and glutamate receptor functional mapping

Current basic science student projects

CLINICAL RESEARCH

My clinical research involves
  • investigating major retinal diseases which cause blindness such as age-related macular degeneration (AMD) and Retinitis Pigmentosa
  • performing image analysis from a range of advanced modalities including optical coherence tomography (OCT), multi-spectral imaging, fundus autofluorscence, infra-red imaging and ultra wide field imaging
  • assessing pathological retinal function using psychophyiscal tests and electrophysiology

 

 Current clinical student projects

 

Research Groups

Research Topics

  • Posterior ocular disease diagnosis through ocular imaging
  • Retinal anatomy, neurochemistry, physiology and pathology

Publications

Conference Papers
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Nivison-Smith L; Zhang C; de Souza C; Michael K; Charles M; Philip P; Angus G; Monica A, 2015, 'Water channel permeability in retinal degeneration. the role of aquaporins', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Cairns, AUSTRALIA, pp. 374 - 374, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, AUSTRALIA, 23 August 2015 - 27 August 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300962&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2015
Conference Abstracts
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Nivison-Smith L; Rogala J; Zangerl B; Assaad N; Fletcher EL; Kalloniatis M, 2015, 'Retinal Layer Thickness in Drusen and Drusen-Free Retinal Areas in Age-Related Macular Degeneration', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Denver, CO, Vol. 56, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Denver, CO, 03 May 2015 - 07 May 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000362891105093&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2015
Journal articles
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Trinh M; Tong J; Yoshioka N; Zangerl B; Kalloniatis M; Nivison-Smith L, 2020, 'Macula Ganglion Cell Thickness Changes Display Location-Specific Variation Patterns in Intermediate Age-Related Macular Degeneration', Investigative ophthalmology & visual science, vol. 61, pp. 2, http://dx.doi.org/10.1167/iovs.61.3.2
2020
Agrawal R; Ding J; Sen P; Rousselot A; Chan A; Nivison-Smith L; Wei X; Mahajan S; Kim R; Mishra C; Agarwal M; Suh MH; Luthra S; Munk MR; Cheung CY; Gupta V, 2020, 'Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index', Progress in Retinal and Eye Research, http://dx.doi.org/10.1016/j.preteyeres.2020.100829
2020
Choi AYJ; Nivison-Smith L; Phu J; Zangerl B; Khuu SK; Jones BW; Pfeiffer RL; Marc RE; Kalloniatis M, 2019, 'Contrast sensitivity isocontours of the central visual field', Scientific Reports, vol. 9, http://dx.doi.org/10.1038/s41598-019-48026-2
2019
Trinh M; Kalloniatis M; Nivison-Smith L, 2019, 'Vascular changes in intermediate age-related macular degeneration quantified using optical coherence tomography angiography', Translational Vision Science and Technology, vol. 8, http://dx.doi.org/10.1167/tvst.8.4.20
2019
Tong J; Phu J; Khuu SK; Yoshioka N; Choi AY; Nivison-Smith L; Marc RE; Jones BW; Pfeiffer RL; Kalloniatis M; Zangerl B, 2019, 'Development of a Spatial Model of Age-Related Change in the Macular Ganglion Cell Layer to Predict Function From Structural Changes', American Journal of Ophthalmology, vol. 208, pp. 166 - 177, http://dx.doi.org/10.1016/j.ajo.2019.04.020
2019
Ly A; Nivison-Smith L; Assaad N; Kalloniatis M, 2018, 'Multispectral pattern recognition reveals a diversity of clinical signs in intermediate age-related macular degeneration', Investigative Ophthalmology and Visual Science, vol. 59, pp. 1790 - 1799, http://dx.doi.org/10.1167/iovs.17-23076
2018
Ly A; Yapp M; Nivison-Smith L; Assaad N; Hennessy M; Kalloniatis M, 2018, 'Developing prognostic biomarkers in intermediate age-related macular degeneration: their clinical use in predicting progression', Clinical and Experimental Optometry, vol. 101, pp. 172 - 181, http://dx.doi.org/10.1111/cxo.12624
2018
Chiang J; Katalinic P; Nivison-Smith L; Yapp M; Zangerl B; Khuu S; Watt K; Kalloniatis M, 2018, 'Teaching Ocular Imaging, Disease Diagnosis and Management Within a Work-Integrated Setting: a Novel Model Within an Optometric Education Program', Journal of Optometric Education, vol. 43, pp. 1 - 18, https://journal.opted.org/article/teaching-ocular-imaging-disease-diagnosis-and-management-within-a-work-integrated-setting-a-novel-model-within-an-optometric-education-program/
2018
Ly A; Nivison-Smith L; Zangerl B; Assaad N; Kalloniatis M, 2018, 'Advanced imaging for the diagnosis of age-related macular degeneration: a case vignettes study', Clinical and Experimental Optometry, vol. 101, pp. 243 - 254, http://dx.doi.org/10.1111/cxo.12607
2018
Nivison-Smith L; Milston R; Chiang J; Ly A; Assaad N; Kalloniatis M, 2018, 'Peripheral retinal findings in populations with macular disease are similar to healthy eyes', Ophthalmic and Physiological Optics, vol. 38, pp. 584 - 595,
2018
Nivison-Smith L; Khoo P; Acosta ML; Kalloniatis M, 2018, 'Vinpocetine protects inner retinal neurons with functional NMDA glutamate receptors against retinal ischemia', Experimental Eye Research, vol. 167, pp. 1 - 13, http://dx.doi.org/10.1016/j.exer.2017.10.008
2018
Ly A; Nivison-Smith L; Assaad N; Kalloniatis M, 2017, 'Fundus Autofluorescence in Age-related Macular Degeneration', Optometry and Vision Science, vol. 94, pp. 246 - 259, http://dx.doi.org/10.1097/OPX.0000000000000997
2017
Yoshioka N; Zangerl B; Nivison-Smith L; Khuu SK; Jones BW; Pfeiffer RL; Marc RE; Kalloniatis M, 2017, 'Pattern recognition analysis of age-related retinal ganglion cell signatures in the human eye', Investigative Ophthalmology and Visual Science, vol. 58, pp. 3086 - 3099, http://dx.doi.org/10.1167/iovs.17-21450
2017
Ly A; Nivison-Smith L; Hennessy M; Kalloniatis M, 2017, 'The advantages of intermediate-tier, inter-optometric referral of low risk pigmented lesions', Ophthalmic and Physiological Optics, vol. 37, pp. 661 - 668, http://dx.doi.org/10.1111/opo.12413
2017
Ly A; Nivison-Smith L; Zangerl B; Assaad N; Kalloniatis M, 2017, 'Self-reported optometric practise patterns in age-related macular degeneration', Clinical and Experimental Optometry, vol. 100, pp. 718 - 728, http://dx.doi.org/10.1111/cxo.12528
2017
Chiang J; Katalinic P; Nivison-Smith L; Yapp M; Khuu S; Watt K; Kalloniatis M, 2017, 'Teaching ocular imaging, disease diagnosis​ and management within a work-integrated setting: a novel model within an optometric education program', Journal of Optometric Education
2017
Phu J; Khuu S; Nivison-Smith L; Zangerl B; Choi Y; Jones B; Pfeiffer R; Kalloniatis M, 2017, 'Pattern Recognition Analysis Reveals Unique Contrast Sensitivity Isocontours Using Static Perimetry Thresholds Across the Visual Field', Investigative Ophthalmology & Visual Science, vol. 58, pp. 4863 - 4876, http://dx.doi.org/10.1167/iovs.17-22371
2017
Nivison-Smith L; Khoo P; Acosta ML; Kalloniatis M, 2017, 'Pre-treatment with vinpocetine protects against retinal ischemia', Experimental Eye Research, vol. 154, pp. 126 - 138, http://dx.doi.org/10.1016/j.exer.2016.11.018
2017
de Souza CF; Nivison-Smith L; Christie DL; Polkinghorne P; McGhee C; Kalloniatis M; Acosta ML, 2016, 'Macromolecular markers in normal human retina and applications to human retinal disease', Experimental Eye Research, vol. 150, pp. 135 - 148, http://dx.doi.org/10.1016/j.exer.2016.01.002
2016
Ly A; Nivison-Smith L; Assaad N; Kalloniatis M, 2016, 'Infrared reflectance imaging in age-related macular degeneration', Ophthalmic and Physiological Optics, vol. 36, pp. 303 - 316, http://dx.doi.org/10.1111/opo.12283
2016
Choi AYJ; Nivison-Smith L; Khuu SK; Kalloniatis M, 2016, 'Determining spatial summation and its effect on contrast sensitivity across the central 20 degrees of visual field', PLoS One, vol. 11, http://dx.doi.org/10.1371/journal.pone.0158263
2016
Kalloniatis M; Nivison-Smith L; Chua J; Acosta ML; Fletcher EL, 2016, 'Using the rd1 mouse to understand functional and anatomical retinal remodelling and treatment implications in retinitis pigmentosa: A review', Experimental Eye Research, vol. 150, pp. 106 - 121, http://dx.doi.org/10.1016/j.exer.2015.10.019
2016
Ly A; Nivison-Smith L; Hennessy MP; Kalloniatis M, 2016, 'Collaborative care of non-urgent macular disease: a study of inter-optometric referrals', Ophthalmic and Physiological Optics, vol. 36, pp. 632 - 642, http://dx.doi.org/10.1111/opo.12322
2016
Phu J; Trinh WH; Chau-Vo J; Nivison-Smith L; Kalloniatis M, 2015, 'Atypical features of Fuchs uveitis syndrome', Optometry and Vision Science, vol. 92, pp. e394 - e403, http://dx.doi.org/10.1097/OPX.0000000000000701
2015
Nivison-Smith L; Obrien BJ; Truong M; Guo CX; Kalloniatis M; Acosta ML, 2015, 'Vinpocetine modulates metabolic activity and function during retinal ischemia', American Journal of Physiology - Cell Physiology, vol. 308, pp. C737 - C749, http://dx.doi.org/10.1152/ajpcell.00291.2014
2015
Wong E; Nivison-Smith L; Assaad NN; Kalloniatis M, 2015, 'OCT and fundus autofluorescence enhances visualization of white dot syndromes', Optometry and Vision Science, vol. 92, pp. 642 - 653, http://dx.doi.org/10.1097/OPX.0000000000000572
2015
Rogala J; Zanger B; Assaad N; Fletcher EL; Kalloniatis M; Nivison-Smith L, 2015, 'In vivo quantification of retinal changes associated with drusen in age-related macular degeneration', Investigative Ophthalmology and Visual Science, vol. 56, pp. 1689 - 1700, http://dx.doi.org/10.1167/iovs.14-16221
2015
Nivison-Smith L; Acosta ML; Misra S; O'Brien BJ; Kalloniatis M, 2014, 'Vinpocetine regulates cation channel permeability of inner retinal neurons in the ischaemic retina', Neurochemistry International, vol. 66, pp. 1 - 14, http://dx.doi.org/10.1016/j.neuint.2014.01.003
2014
Nivison-Smith L; Milston R; Madigan M; Kalloniatis M, 2014, 'Age-related macular degeneration: Linking clinical presentation to pathology', Optometry and Vision Science, vol. 91, pp. 832 - 848, http://dx.doi.org/10.1097/OPX.0000000000000281
2014
Nivison-Smith L; Chua J; Tan SS; Kalloniatis M, 2014, 'Amino acid signatures in the developing mouse retina', International Journal of Developmental Neuroscience, vol. 33, pp. 62 - 80, http://dx.doi.org/10.1016/j.ijdevneu.2013.12.005
2014
Nivison-Smith L; Zhu Y; Whatham A; Bui BV; Fletcher EL; Acosta ML; Kalloniatis M, 2014, 'Sildenafil alters retinal function in mouse carriers of Retinitis Pigmentosa', Experimental Eye Research, vol. 128, pp. 43 - 56, http://dx.doi.org/10.1016/j.exer.2014.08.014
2014
Chua J; Nivison-Smith L; Tan SS; Kalloniatis M, 2013, 'Metabolic profiling of the mouse retina using amino acid signatures: Insight into developmental cell dispersion patterns', Experimental Neurology, vol. 250, pp. 74 - 93, http://dx.doi.org/10.1016/j.expneurol.2013.09.007
2013
Chua J; Nivison-Smith L; Fletcher EL; Trenholm S; Awatramani G; Kalloniatis M, 2013, 'Early remodeling of Müller cells in the rd/rd mouse model of retinal dystrophy', Journal of Comparative Neurology, vol. 521, pp. 2439 - 2453, http://dx.doi.org/10.1002/cne.23307
2013
Zhu Y; Mistra S; Nivison-Smith L; Acosta ML; Fletcher EL; Kalloniatis M, 2013, 'Erratum: Mapping cation entry in photoreceptors and inner retinal neurons during early degeneration in the P23H-3 rat retina (Visual Neuroscience (2013) DOI: 10.1017/S0952523813000047)', Visual Neuroscience, vol. 30, pp. 121, http://dx.doi.org/10.1017/S0952523813000047
2013
Nivison-Smith L; Sun D; Fletcher EL; Marc R; Kalloniatis M, 2013, 'Mapping kainate activation of inner neurons in the rat retina', Journal of Comparative Neurology, vol. 521, pp. 2416 - 2438, http://dx.doi.org/10.1002/cne.23305
2013
Nivison-Smith L; Collin SP; Zhu Y; Ready S; Acosta ML; Hunt DM; Potter IC; Kalloniatis M, 2013, 'Correction: Retinal Amino Acid Neurochemistry of the Southern Hemisphere Lamprey,.', PloS one, vol. 8, http://dx.doi.org/10.1371/annotation/99baec7f-908c-4e88-8a87-a25f2aa1630c
2013
Kalloniatis M; Loh CS; Acosta M; Tomisich G; Zhu Y; Nivison-Smith L; Fletcher EL; Chua J; Sun D; Arunthavasothy N, 2013, 'Retinal amino acid neurochemistry in health and disease', Clinical and Experimental Optometry, vol. 7, pp. 1 - 18, http://dx.doi.org/10.1111/cxo.12015
2013
Nivison-Smith L; Collin S; Zhu Y; Ready S; Acosta M; Hunt D; Potter I; Kalloniatis M, 2013, 'Retinal Amino Acid Neurochemistry of the Southern Hemisphere Lamprey, Geotria australis.', PLoS ONE, vol. 8, pp. e58406, http://dx.doi.org/10.1371/journal.pone.0058406
2013
Zhu Y; Mistra S; Nivison-Smith L; Acosta ML; Fletcher EL; Kalloniatis M, 2013, 'Mapping cation entry in photoreceptors and inner retinal neurons during early degeneration in the P23H-3 rat retina', Visual Neuroscience, vol. 30, pp. 65 - 75, http://dx.doi.org/10.1017/S0952523813000047
2013
Nivison-Smith L; Weiss AS, 2012, 'Alignment of human vascular smooth muscle cells on parallel electrospun synthetic elastin fibers', Journal of Biomedical Materials Research - Part A, vol. 100 A, pp. 155 - 161, http://dx.doi.org/10.1002/jbm.a.33255
2012
Nivison-Smith L; Rnjak J; Weiss AS, 2010, 'Synthetic human elastin microfibers: Stable cross-linked tropoelastin and cell interactive constructs for tissue engineering applications', Acta Biomaterialia, vol. 6, pp. 354 - 359, http://dx.doi.org/10.1016/j.actbio.2009.08.011
2010
Grant A; Trompf K; Seung D; Nivison-Smith L; Bowcock H; Kresse H; Holmes S; Radford J; Morrow P, 2010, 'Sub-cellular damage by copper in the cnidarian Zoanthus robustus', Comparative Biochemistry and Physiology - C Toxicology and Pharmacology, vol. 152, pp. 256 - 262, http://dx.doi.org/10.1016/j.cbpc.2010.04.013
2010
Almine JF; Bax DV; Mithieux SM; Smith LN; Rnjak J; Waterhouse A; Wise SG; Weiss AS, 2010, 'Elastin-based materials', Chemical Society Reviews, vol. 39, pp. 3371 - 3379, http://dx.doi.org/10.1039/b919452p
2010
Almine JF; Bax DV; Mithieux SM; Nivison-Smith L; Rnjak J; Waterhouse A; Wise SG; Weiss AS, 2010, 'ChemInform Abstract: Elastin-Based Materials', ChemInform, vol. 41, pp. no - no, http://dx.doi.org/10.1002/chin.201051252
2010