Lisa Nivison-Smith

 

ABOUT ME:

My research interests lie in the fundamental biology of the healthy and diseased retina. I specifically focus on anatomical and neurochemical modifications which occur in the early stages of disease prior to permanent vision loss. I study retinal neurobiology in two ways: (1) I use clinical approach, assessing data obtained from patients attending the Centre For Eye Health on the UNSW campus and (2) I use a basic science approach, assessing rodent models of retinal disease at different stages. This research is highly significant as it focuses on early disease, allowing us to potentially determine the underlying mechanism/s of disease. In addition, many interventions for blinding diseases such as the bionic eye or stem cell transplantation, depend on accurate knowledge of the retinal architecture in retinal disease. This research can provide these modified anatomical and functional roadmaps of the diseased retina as well as discover new intervention points for new therapeutics. 

For further information on my research, please visit the Retinal Networks Laboratory or my Facebook page  

 

BASIC SCIENCE RESEARCH

My basic science research involves

  • animal models of inherited retinal dystrophies (rd1 mouse, P23H rat),
  • carriers of retinal dystrophies (heterozygous rd1 mouse)
  • animal models for retinal metabolic conditions (ischaemia model via elevated IOP).
  • a range of techniques to assess the retina including histology, immunocytochemistry, microscopy, rodent electroretinography (ERG), metabolic assays and glutamate receptor functional mapping

Current basic science student projects

CLINICAL RESEARCH

My clinical research involves
  • investigating major retinal diseases which cause blindness such as age-related macular degeneration (AMD) and Retinitis Pigmentosa
  • performing image analysis from a range of advanced modalities including optical coherence tomography (OCT), multi-spectral imaging, fundus autofluorscence, infra-red imaging and ultra wide field imaging
  • assessing pathological retinal function using psychophyiscal tests and electrophysiology

 

 Current clinical student projects

 

     

       

       

      Publications

      Conference Papers
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      Ly A; Nivison-Smith L; Yapp M; Kalloniatis M, 2017, 'Referral pathways for non-urgent macular disease', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Baltimore, MD, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Baltimore, MD, 07 May 2017 - 11 May 2017,
      2017
      Nivison-Smith L; Zhang C; de Souza C; Michael K; Charles M; Philip P; Angus G; Monica A, 2015, 'Water channel permeability in retinal degeneration. the role of aquaporins', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Cairns, AUSTRALIA, pp. 374 - 374, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, AUSTRALIA, 23 August 2015 - 27 August 2015,
      2015
      Conference Abstracts
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      Nivison-Smith L; Tan N; Yoshioka N; Choi AYJ; Zangerl B; Kalloniatis M, 2018, 'Changes in inner retinal thickness in age-related macular degeneration (AMD) detected using a grid-wise analysis of optical coherence tomography scans.', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Honolulu, HI, Vol. 59, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honolulu, HI, 29 April 2018 - 03 May 2018,
      2018
      Nivison-Smith L; Wang H; Assaad N; Kalloniatis M, 2018, 'Retinal Thickness Changes throughout the Natural History of Drusen in Age-related Macular Degeneration', in Optometry and Vision Science, Vol. 95, pp. 648 - 655,
      2018
      Ly A; Nivison-Smith L; Zangerl B; Kalloniatis M, 2016, 'Practice patterns in age-related macular degeneration (AMD)', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Seattle, WA, Vol. 57, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Seattle, WA, 01 May 2016 - 05 May 2016,
      2016
      Nivison-Smith L; Rogala J; Zangerl B; Assaad N; Fletcher EL; Kalloniatis M, 2015, 'Retinal Layer Thickness in Drusen and Drusen-Free Retinal Areas in Age-Related Macular Degeneration', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Denver, CO, Vol. 56, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Denver, CO, 03 May 2015 - 07 May 2015,
      2015
      Journal articles
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      Trinh M; Kalloniatis M; Nivison-Smith L, 2019, 'Vascular Changes in Intermediate Age-Related Macular Degeneration Quantified Using Optical Coherence Tomography Angiography', TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, vol. 8,
      2019
      Nivison-Smith L; Milston R; Chiang J; Ly A; Assaad N; Kalloniatis M, 2018, 'Peripheral retinal findings in populations with macular disease are similar to healthy eyes', Ophthalmic and Physiological Optics, vol. 38, pp. 584 - 595,
      2018
      Nivison-Smith L; Milston R; Chiang J; Ly A; Assaad N; Kalloniatis M, 2018, 'Peripheral retinal findings in populations with macular disease are similar to healthy eyes', Ophthalmic and Physiological Optics, vol. 38, pp. 584 - 595,
      2018
      Ly A; Yapp M; Nivison-Smith L; Assaad N; Hennessy M; Kalloniatis M, 2018, 'Developing prognostic biomarkers in intermediate age-related macular degeneration: their clinical use in predicting progression', Clinical and Experimental Optometry, vol. 101, pp. 172 - 181,
      2018
      Ly A; Nivison-Smith L; Assaad N; Kalloniatis M, 2018, 'Multispectral pattern recognition reveals a diversity of clinical signs in intermediate age-related macular degeneration', Investigative Ophthalmology and Visual Science, vol. 59, pp. 1790 - 1799,
      2018
      Nivison-Smith L; Khoo P; Acosta ML; Kalloniatis M, 2018, 'Vinpocetine protects inner retinal neurons with functional NMDA glutamate receptors against retinal ischemia', Experimental Eye Research, vol. 167, pp. 1 - 13,
      2018
      Ly A; Nivison-Smith L; Zangerl B; Assaad N; Kalloniatis M, 2018, 'Advanced imaging for the diagnosis of age-related macular degeneration: a case vignettes study', Clinical and Experimental Optometry, vol. 101, pp. 243 - 254,
      2018
      Ly A; Nivison-Smith L; Zangerl B; Assaad N; Kalloniatis M, 2017, 'Self-reported optometric practise patterns in age-related macular degeneration', Clinical and Experimental Optometry, vol. 100, pp. 718 - 728,
      2017
      Nivison-Smith L; Khoo P; Acosta ML; Kalloniatis M, 2017, 'Pre-treatment with vinpocetine protects against retinal ischemia', Experimental Eye Research, vol. 154, pp. 126 - 138,
      2017
      Ly A; Nivison-Smith L; Assaad N; Kalloniatis M, 2017, 'Fundus Autofluorescence in Age-related Macular Degeneration', Optometry and Vision Science, vol. 94, pp. 246 - 259,
      2017
      Ly A; Nivison-Smith L; Hennessy M; Kalloniatis M, 2017, 'The advantages of intermediate-tier, inter-optometric referral of low risk pigmented lesions', Ophthalmic and Physiological Optics, vol. 37, pp. 661 - 668,
      2017
      Ly A; Nivison-Smith L; Hennessy MP; Kalloniatis M, 2016, 'Collaborative care of non-urgent macular disease: a study of inter-optometric referrals', Ophthalmic and Physiological Optics, vol. 36, pp. 632 - 642,
      2016
      Ly A; Nivison-Smith L; Assaad N; Kalloniatis M, 2016, 'Infrared reflectance imaging in age-related macular degeneration', Ophthalmic and Physiological Optics, vol. 36, pp. 303 - 316,
      2016
      de Souza CF; Nivison-Smith L; Christie DL; Polkinghorne P; McGhee C; Kalloniatis M; Acosta ML, 2016, 'Macromolecular markers in normal human retina and applications to human retinal disease', Experimental Eye Research, vol. 150, pp. 135 - 148,
      2016
      Kalloniatis M; Nivison-Smith L; Chua J; Acosta ML; Fletcher EL, 2016, 'Using the rd1 mouse to understand functional and anatomical retinal remodelling and treatment implications in retinitis pigmentosa: A review', Experimental Eye Research, vol. 150, pp. 106 - 121,
      2016
      Ly A; Nivison-Smith L; Hennessy M; Kalloniatis M, 2015, 'Pigmented lesions of the retinal pigment epithelium', Optometry and Vision Science, vol. 92, pp. 844 - 857,
      2015
      Wong E; Nivison-Smith L; Assaad NN; Kalloniatis M, 2015, 'OCT and fundus autofluorescence enhances visualization of white dot syndromes', Optometry and Vision Science, vol. 92, pp. 642 - 653,
      2015
      Rogala J; Zanger B; Assaad N; Fletcher EL; Kalloniatis M; Nivison-Smith L, 2015, 'In vivo quantification of retinal changes associated with drusen in age-related macular degeneration', Investigative Ophthalmology and Visual Science, vol. 56, pp. 1689 - 1700,
      2015
      Rogala J; Zangerl B; Assaad N; Fletcher EL; Kalloniatis M; Nivison-Smith L, 2015, 'In Vivo Quantification of Retinal Changes Associated With Drusen in Age-Related Macular Degeneration (vol 56, pg 1689, 2015)', INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 56, pp. 4125 - 4128,
      2015
      Nivison-Smith L; Obrien BJ; Truong M; Guo CX; Kalloniatis M; Acosta ML, 2015, 'Vinpocetine modulates metabolic activity and function during retinal ischemia', American Journal of Physiology - Cell Physiology, vol. 308, pp. C737 - C749,
      2015
      Phu J; Trinh WH; Chau-Vo J; Nivison-Smith L; Kalloniatis M, 2015, 'Atypical features of Fuchs uveitis syndrome', Optometry and Vision Science, vol. 92, pp. e394 - e403,
      2015
      Nivison-Smith L; Milston R; Madigan M; Kalloniatis M, 2014, 'Age-related macular degeneration: Linking clinical presentation to pathology', Optometry and Vision Science, vol. 91, pp. 832 - 848,
      2014
      Nivison-Smith L; Zhu Y; Whatham A; Bui BV; Fletcher EL; Acosta ML; Kalloniatis M, 2014, 'Sildenafil alters retinal function in mouse carriers of Retinitis Pigmentosa', Experimental Eye Research, vol. 128, pp. 43 - 56,
      2014
      Nivison-Smith L; Acosta ML; Misra S; O'Brien BJ; Kalloniatis M, 2014, 'Vinpocetine regulates cation channel permeability of inner retinal neurons in the ischaemic retina', Neurochemistry International, vol. 66, pp. 1 - 14,
      2014
      Nivison-Smith L; Chua J; Tan SS; Kalloniatis M, 2014, 'Amino acid signatures in the developing mouse retina', International Journal of Developmental Neuroscience, vol. 33, pp. 62 - 80,
      2014
      Nivison-Smith L; Sun D; Fletcher EL; Marc R; Kalloniatis M, 2013, 'Mapping kainate activation of inner neurons in the rat retina', Journal of Comparative Neurology, vol. 521, pp. 2416 - 2438,
      2013
      Nivison-Smith L; Collin SP; Zhu Y; Ready S; Acosta ML; Hunt DM; Potter IC; Kalloniatis M, 2013, 'Correction: Retinal Amino Acid Neurochemistry of the Southern Hemisphere Lamprey,.', PloS one, vol. 8,
      2013
      Zhu Y; Mistra S; Nivison-Smith L; Acosta ML; Fletcher EL; Kalloniatis M, 2013, 'Mapping cation entry in photoreceptors and inner retinal neurons during early degeneration in the P23H-3 rat retina', Visual Neuroscience, vol. 30, pp. 65 - 75,
      2013
      Chua J; Nivison-Smith L; Tan SS; Kalloniatis M, 2013, 'Metabolic profiling of the mouse retina using amino acid signatures: Insight into developmental cell dispersion patterns', Experimental Neurology, vol. 250, pp. 74 - 93,
      2013
      Zhu Y; Mistra S; Nivison-Smith L; Acosta ML; Fletcher EL; Kalloniatis M, 2013, 'Erratum: Mapping cation entry in photoreceptors and inner retinal neurons during early degeneration in the P23H-3 rat retina (Visual Neuroscience (2013) DOI: 10.1017/S0952523813000047)', Visual Neuroscience, vol. 30, pp. 121,
      2013
      Nivison-Smith L; Collin S; Zhu Y; Ready S; Acosta M; Hunt D; Potter I; Kalloniatis M, 2013, 'Retinal Amino Acid Neurochemistry of the Southern Hemisphere Lamprey, Geotria australis.', PLoS ONE, vol. 8, pp. e58406,
      2013
      Kalloniatis M; Loh CS; Acosta M; Tomisich G; Zhu Y; Nivison-Smith L; Fletcher EL; Chua J; Sun D; Arunthavasothy N, 2013, 'Retinal amino acid neurochemistry in health and disease', Clinical and Experimental Optometry, vol. 7, pp. 1 - 18,
      2013
      Chua J; Nivison-Smith L; Fletcher EL; Trenholm S; Awatramani G; Kalloniatis M, 2013, 'Early remodeling of Müller cells in the rd/rd mouse model of retinal dystrophy', Journal of Comparative Neurology, vol. 521, pp. 2439 - 2453,
      2013
      Nivison-Smith L; Weiss AS, 2012, 'Alignment of human vascular smooth muscle cells on parallel electrospun synthetic elastin fibers', Journal of Biomedical Materials Research - Part A, vol. 100 A, pp. 155 - 161,
      2012
      Almine JF; Bax DV; Mithieux SM; Nivison-Smith L; Rnjak J; Waterhouse A; Wise SG; Weiss AS, 2010, 'ChemInform Abstract: Elastin-Based Materials', ChemInform, vol. 41, pp. no - no,
      2010
      Nivison-Smith L; Rnjak J; Weiss AS, 2010, 'Synthetic human elastin microfibers: Stable cross-linked tropoelastin and cell interactive constructs for tissue engineering applications', Acta Biomaterialia, vol. 6, pp. 354 - 359,
      2010
      Grant A; Trompf K; Seung D; Nivison-Smith L; Bowcock H; Kresse H; Holmes S; Radford J; Morrow P, 2010, 'Sub-cellular damage by copper in the cnidarian Zoanthus robustus', Comparative Biochemistry and Physiology - C Toxicology and Pharmacology, vol. 152, pp. 256 - 262,
      2010
      Almine JF; Bax DV; Mithieux SM; Nivison-Smith L; Rnjak J; Waterhouse A; Wise SG; Weiss AS, 2010, 'Elastin-based materials', Chemical Society Reviews, vol. 39, pp. 3371 - 3379,
      2010