Maria Markoulli

Senior Lecturer and Postgraduate Research Coordinator
Senior Lecturer

Dr Maria Markoulli is an Optometrist and Senior Lecturer at the School of Optometry and Vision Science at UNSW. Her research interests lie within tear film biochemistry and the ocular surface. In particular, her research goals are to:

  1. understand the impact that systemic disease, such as diabetes, can have on corneal nerves and tear film biochemistry
  2. characterise the impact of dry eye disease and meibomian gland dysfunction on the ocular surface and identify effective treatments
  3. minimise contact lens-related adverse events

 

 Awards 

  • 2019 UNSW ARC Postgraduate Supervisor Award
  • 2019 UNSW Women in Maths and Science Champion
  • 2019 UNSW School of Optometry and Vision Science Research Excellence Award
  • 2017 UNSW Vice-Chancellor's Award for Teaching Excellence
  • 2016 Juvenile Diabetes Research Foundation travel grant
  • 2015 Certificate for Teaching Excellence (Faculty of Science, UNSW)
  • 64th Meeting of the Nobel Laureates, Lindau, Germany: Selected by the Group of Eight and the Australian Academy of Science to attend, 2014
  • UNSW Early Career Researchers grant 2013
  • William C. Ezell Fellowship (American Optometric Foundation), 2009 & 2010
  • OVRF-Maki Shiobara Scholarship, 2010 
  • Tear Film and Ocular Surface Travel Award, 2010
  • Cornea and Contact Lens Society of Australia Scholarship, 2010
  • Postgraduate Research Scheme Scholarship, 2010
  • Australian Postgraduate Award (Australian Government), 2008-2011
  • Ciba Vision Pty Ltd Prize for Excellence in Contact Lenses, 2004
  • David Bard Scholarship (University of New South Wales), 2002
  • Faculty of Science Scholarship for 4 years (University of New South Wales), 2000-2003

Teaching

  • OPTM3133: Course convenor for ‘Vision Science in the Consulting Room’ in Term 2 (BVisSci students)
  • OPTM6400: Course convenor for 'Optometric Preclinical Practice' in Term 1 (MClinOptom students)
  • Academic lead for the UNSW Dry Eye Clinic
  • Dry eye lectures

Engagement and Leadership

  • Postgraduate Coordinator
  • Deputy Editor: Clinical and Experimental Optometry
  • Board member: The Optical Foundation
  • Tear Film and Ocular Surface (TFOS) Young Investigator committee member
  • TFOS International Workshop on Contact Lens Discomfort Subcommittee member
  • TFOS Dry Eye Workshop II Subcommittee member

Professional memberships

  • Optometrists Association of Australia
  • Ezell Club, American Optometric Foundation
  • Fellow and Member of the American Academy of Optometry
  • Fellow and Member of British Contact Lens Association
  • Member of the International Society of Contact Lens Researchers
  • TFOS
  • Association for researchers in vision and ophthalmology

Research Groups

Research Topics

  • Dry eye: contact lens wear, innervation and symptoms, sex hormones
  • Ocular surface disease: allergy, biomarkers, diabetes, keratoconus, obesity and nutrition
  • Tear film biochemistry, ocular homeostasis and pathology
  • Use of alternative and complementary medicines

Publications

Conference Papers
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Tummanapalli SS; Willcox M; Issar T; Yan A; Kwai N; Poynten A; Krishnan A; Markoulli M, 2019, 'Reduced tear film substance P concentration is associated with diabetic peripheral neuropathy', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Vancouver, CANADA, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Vancouver, CANADA, 28 April 2019 - 02 May 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000488800703078&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2019
Markoulli M; Sengmany K; Xie K; Dutta D, 2018, 'Corneal nerve morphology and dry eye people with diabetes.', in Corneal nerve morphology and dry eye people with diabetes., American Academy of Optometry, San Antonio, USA, presented at American Academy of Optometry, San Antonio, USA, 07 November 2018 - 10 August 2018
2018
Tummanapalli SS; Issar T; Kwai N; Poyten A; Krishnan A; Willcox MDP; Markoulli M, 2018, 'Assessment of corneal nerve structure and peripheral nerve function in detection of diabetic peripheral neuropathy', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Honolulu, HI, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honolulu, HI, 29 April 2018 - 03 May 2018
2018
Tummanapalli SS; Issar T; Kwai N; Poyten A; Krishnan A; Willcox MD P; Markoulli M, 2018, 'Assessment of corneal nerve structure and peripheral nerve function in detection of diabetic peripheral neuropathy', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Honolulu, HI, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honolulu, HI, 29 April - 03 May 2018,
2018
Markoulli M; Colorado LH; Edwards K, 2018, 'Corneal nerve morphology and its association with inflammatory mediators and neuropeptides in the healthy tear film', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Honolulu, HI, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honolulu, HI, 29 April 2018 - 03 May 2018
2018
Markoulli M; Colorado LH; Edwards K, 2018, 'Corneal nerve morphology and its association with inflammatory mediators and neuropeptides in the healthy tear film', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Honolulu, HI, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honolulu, HI, 29 April - 03 May 2018,
2018
Yeotikar NS; Zhu H; Omali NB; Tilia D; Thomas V; Markoulli M; Nichols KK; Nichols JJ; Papas EB, 2014, 'The natural history of meibomian glands: Age-related changes in an asymptomatic population', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000433199700010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2014
Conference Abstracts
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Yeotikar NS; Flanagan J; Naduvilath TJ; Markoulli M; Tilia D; Papas EB, 2018, 'Association between meibomian lipid profiles and age-related changes in gland morphology and function', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Honolulu, HI, Vol. 59, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honolulu, HI, 29 April 2018 - 03 May 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000442932804343&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
2018
Stapleton F; Chao C; Jalbert I; Mandathara P; Kolanu S; Willcox M; Markoulli M; You JJ; Kim J; Lum E; Golebiowski B, 2016, 'Relationships between central corneal nerve parameters and tear neuropeptides', in Invest Ophthalmol Vis Sci, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Seattle, WA, Vol. 57, pp. E - abstract 2796, presented at ARVO Annual Meeting, Seattle, WA, 01 May 2016 - 05 May 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000394210605041&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
2016
Journal articles
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Tummanapalli SS; Issar T; Kwai N; Poynten A; Krishnan AV; Willcox M; Markoulli M, 2020, 'Association of corneal nerve loss with markers of axonal ion channel dysfunction in type 1 diabetes', Clinical Neurophysiology, vol. 131, pp. 145 - 154, http://dx.doi.org/10.1016/j.clinph.2019.09.029
2020
Tummanapalli SS; Issar T; Yan A; Kwai N; Poynten AM; Krishnan AV; Willcox MDP; Markoulli M, 2020, 'Corneal nerve fiber loss in diabetes with chronic kidney disease', Ocular Surface, vol. 18, pp. 178 - 185, http://dx.doi.org/10.1016/j.jtos.2019.11.010
2020
Tummanapalli SS; Issar T; Kwai N; Poynten A; Krishnan AV; Willcox M; Markoulli M, 2020, 'Erratum to ‘Association of corneal nerve loss with markers of axonal ion channel dysfunction in type 1 diabetes’. (Clinical Neurophysiology (2020) 131(1) (145–154), (S1388245719312726), (10.1016/j.clinph.2019.09.029))', Clinical Neurophysiology, vol. 131, pp. 780, http://dx.doi.org/10.1016/j.clinph.2020.01.001
2020
Issar T; Tummanapalli SS; Kwai NCG; Chiang JCB; Arnold R; Poynten AM; Markoulli M; Krishnan AV, 2020, 'Associations between acute glucose control and peripheral nerve structure and function in type 1 diabetes.', Diabet Med, http://dx.doi.org/10.1111/dme.14306
2020
Mehrgardt P; Zandavi SM; Poon SK; Kim J; Markoulli M; Khushi M, 2020, 'U-net segmented adjacent angle detection (Usaad) for automatic analysis of corneal nerve structures', Data, vol. 5, http://dx.doi.org/10.3390/data5020037
2020
Chiang JCB; Zahari I; Markoulli M; Krishnan AV; Park SB; Semmler A; Goldstein D; Edwards K, 2020, 'The impact of anticancer drugs on the ocular surface', Ocular Surface, vol. 18, pp. 403 - 417, http://dx.doi.org/10.1016/j.jtos.2020.03.008
2020
Alghamdi W; Markoulli M; Papas E, 2020, 'The relationship between tear film MMP-9 and meibomian gland changes during soft contact lens wear', Contact Lens and Anterior Eye, vol. 43, pp. 154 - 158, http://dx.doi.org/10.1016/j.clae.2019.07.007
2020
Markoulli M; Colorado LH; Edwards K, 2020, 'The Relationship between Corneal Nerve Morphology and Inflammatory Mediators and Neuropeptides in Healthy Individuals', Optometry and vision science : official publication of the American Academy of Optometry, vol. 97, pp. 145 - 153, http://dx.doi.org/10.1097/OPX.0000000000001484
2020
Markoulli M, 2020, 'Women in optometry and vision science', Clinical and Experimental Optometry, vol. 103, pp. 131 - 132, http://dx.doi.org/10.1111/cxo.13052
2020
Markoulli M; Jalbert I, 2020, 'Scientia Professor Fiona Stapleton: leading academic and world-renowned epidemiologist of contact lens-related eye disease.', Clin Exp Optom, http://dx.doi.org/10.1111/cxo.13085
2020
Yan A; Issar T; Tummanapalli SS; Markoulli M; Kwai NCG; Poynten AM; Krishnan AV, 2020, 'Relationship between corneal confocal microscopy and markers of peripheral nerve structure and function in Type 2 diabetes', Diabetic Medicine, vol. 37, pp. 326 - 334, http://dx.doi.org/10.1111/dme.13952
2020
Tummanapalli SS; Willcox MDP; Issar T; Kwai N; Poynten AM; Krishnan AV; Pisarcikova J; Markoulli M, 2020, 'The Effect of Age, Gender and Body Mass Index on Tear Film Neuromediators and Corneal Nerves', Current Eye Research, vol. 45, pp. 411 - 418, http://dx.doi.org/10.1080/02713683.2019.1666998
2020
López-de la Rosa A; Alghamdi WM; Kunnen CME; Lazon de la Jara P; González-García MJ; Markoulli M; Papas EB, 2019, 'Changes in the tarsal conjunctiva viewed by in vivo confocal microscopy are associated with ocular symptoms and contact lens wear', Ophthalmic and Physiological Optics, vol. 39, pp. 328 - 336, http://dx.doi.org/10.1111/opo.12638
2019
Tummanapalli SS; Willcox MDP; Issar T; Yan A; Pisarcikova J; Kwai N; Poynten AM; Krishnan AV; Markoulli M, 2019, 'Tear film substance P: A potential biomarker for diabetic peripheral neuropathy', Ocular Surface, vol. 17, pp. 690 - 698, http://dx.doi.org/10.1016/j.jtos.2019.08.010
2019
Tummanapalli SS; Issar T; Kwai N; Pisarcikova J; Poynten AM; Krishnan AV; Willcox MDP; Markoulli M, 2019, 'A Comparative Study on the Diagnostic Utility of Corneal Confocal Microscopy and Tear Neuromediator Levels in Diabetic Peripheral Neuropathy', Current Eye Research, pp. 1 - 10, http://dx.doi.org/10.1080/02713683.2019.1705984
2019
Dutta D; Kim J; Sarkes M; Nath S; Markoulli M, 2019, 'The repeatability of subjective and objective tear ferning assessment and its association with lipid layer thickness, non-invasive tear break-up time and comfort', Contact Lens and Anterior Eye, vol. 42, pp. 420 - 427, http://dx.doi.org/10.1016/j.clae.2019.04.003
2019
Dutta D; Kim J; Sarkes M; Nath S; Markoulli M, 2019, 'The repeatability of subjective and objective tear ferning assessment and its association with lipid layer thickness, non-invasive tear break-up time and comfort', Contact Lens and Anterior Eye, vol. 42, pp. 420 - 427,
2019
Markoulli M, 2019, 'Professor Mark Willcox: the 2017 H Barry Collin Research Medallist', Clinical and Experimental Optometry, vol. 102, pp. 349, http://dx.doi.org/10.1111/cxo.12925
2019
Markoulli M; Hui A, 2019, 'Emerging targets of inflammation and tear secretion in dry eye disease', Drug Discovery Today, vol. 24, pp. 1427 - 1432, http://dx.doi.org/10.1016/j.drudis.2019.02.006
2019
Colorado LH; Markoulli M; Edwards K, 2019, 'The Relationship Between Corneal Dendritic Cells, Corneal Nerve Morphology and Tear Inflammatory Mediators and Neuropeptides in Healthy Individuals', Current Eye Research,
2019
Bron AJ; de Paiva CS; Chauhan SK; Bonini S; Gabison EE; Jain S; Knop E; Markoulli M; Ogawa Y; Perez V; Uchino Y; Yokoi N; Zoukhri D; Sullivan DA, 2019, 'Corrigendum to “TFOS DEWS II pathophysiology report” (The Ocular Surface (2017) 15(3) (438–510), (S1542012417301349), (10.1016/j.jtos.2017.05.011))', Ocular Surface, vol. 17, pp. 842, http://dx.doi.org/10.1016/j.jtos.2019.08.007
2019
Yan A; Issar T; Tummanapalli SS; Markoulli M; Kwai NC G; Poynten AM; Krishnan AV, 2019, 'Relationship between corneal confocal microscopy and markers of peripheral nerve structure and function in Type 2 diabetes', Diabetic Medicine,
2019
Colorado LH; Markoulli M; Edwards K, 2019, 'The Relationship Between Corneal Dendritic Cells, Corneal Nerve Morphology and Tear Inflammatory Mediators and Neuropeptides in Healthy Individuals', Current Eye Research, vol. 44, pp. 840 - 848, http://dx.doi.org/10.1080/02713683.2019.1600196
2019
Markoulli M; Sobbizadeh A; Tan J; Briggs N; Coroneo M, 2018, 'The Effect of Optive and Optive Advanced Artificial Tears on the Healthy Tear Film', Current Eye Research, vol. 43, pp. 588 - 594, http://dx.doi.org/10.1080/02713683.2018.1433860
2018
Markoulli M; Duong TB; Lin M; Papas E, 2018, 'Imaging the Tear Film: A Comparison Between the Subjective Keeler Tearscope-Plus™ and the Objective Oculus® Keratograph 5M and LipiView® Interferometer', Current Eye Research, vol. 43, pp. 155 - 162, http://dx.doi.org/10.1080/02713683.2017.1393092
2018
Markoulli M; Flanagan J; Tummanapalli SS; Wu J; Willcox M, 2018, 'The impact of diabetes on corneal nerve morphology and ocular surface integrity', Ocular Surface, vol. 16, pp. 45 - 57, http://dx.doi.org/10.1016/j.jtos.2017.10.006
2018
Alghamdi WM; Markoulli M; Papas EB, 2018, 'The Effect of Contact Lens Wear on the Cellular Morphology of the Lid Wiper Area', Optometry and Vision Science, vol. 95, pp. 491 - 497, http://dx.doi.org/10.1097/OPX.0000000000001224
2018
Kim J; Markoulli M, 2018, 'Automatic analysis of corneal nerves imaged using in vivo confocal microscopy', Clinical and Experimental Optometry, vol. 101, pp. 147 - 161, http://dx.doi.org/10.1111/cxo.12640
2018
Wang MTM; Tien L; Han A; Lee JM; Kim D; Markoulli M; Craig JP, 2018, 'Impact of blinking on ocular surface and tear film parameters', Ocular Surface, vol. 16, pp. 424 - 429, http://dx.doi.org/10.1016/j.jtos.2018.06.001
2018
Bron AJ; de Paiva CS; Chauhan SK; Bonini S; Gabison EE; Jain S; Knop E; Markoulli M; Ogawa Y; Perez V; Uchino Y; Yokoi N; Zoukhri D; Sullivan DA, 2017, 'TFOS DEWS II pathophysiology report', Ocular Surface, vol. 15, pp. 438 - 510, http://dx.doi.org/10.1016/j.jtos.2017.05.011
2017
Markoulli M; Kolanu S, 2017, 'Contact lens wear and dry eyes: Challenges and solutions', Clinical Optometry, vol. 9, pp. 41 - 48, http://dx.doi.org/10.2147/OPTO.S111130
2017
Markoulli M; Gokhale M; You J, 2017, 'Substance p in flush tears and schirmer strips of healthy participants', Optometry and Vision Science, vol. 94, pp. 527 - 533, http://dx.doi.org/10.1097/OPX.0000000000001040
2017
Markoulli M; You J; Kim J; Duong CL; Tolentino JB; Karras J; Lum E, 2017, 'Corneal nerve morphology and tear film substance p in diabetes', Optometry and Vision Science, vol. 94, pp. 726 - 731, http://dx.doi.org/10.1097/OPX.0000000000001096
2017
Markoulli M; Isa NAMD; Papas EB, 2017, 'Temporal Characteristics of Sodium Fluorescein in the Tear Meniscus', Optometry and Vision Science, vol. 94, pp. 166 - 173, http://dx.doi.org/10.1097/OPX.0000000000001012
2017
Jones LW; Byrne M; Ciolino JB; Legerton J; Markoulli M; Papas E; Subbaraman L, 2016, 'Revolutionary future uses of contact lenses', Optometry and Vision Science, vol. 93, pp. 325 - 327, http://dx.doi.org/10.1097/OPX.0000000000000847
2016
Flanagan JL; Khandekar N; Zhu H; Watanabe K; Markoulli M; Flanagan JT; Papas E, 2016, 'Glycerol monolaurate inhibits lipase production by clinical ocular isolates without affecting bacterial cell viability', Investigative Ophthalmology and Visual Science, vol. 57, pp. 544 - 550, http://dx.doi.org/10.1167/iovs.15-17180
2016
Alghamdi WM; Markoulli M; Holden BA; Papas EB, 2016, 'Impact of duration of contact lens wear on the structure and function of the meibomian glands', Ophthalmic and Physiological Optics, vol. 36, pp. 120 - 131, http://dx.doi.org/10.1111/opo.12278
2016
Yeotikar NS; Zhu H; Markoulli M; Nichols KK; Naduvilath T; Papas EB, 2016, 'Functional and morphologic changes of meibomian glands in an asymptomatic adult population', Investigative Ophthalmology and Visual Science, vol. 57, pp. 3996 - 4007, http://dx.doi.org/10.1167/iovs.15-18467
2016
Markoulli M, 2014, 'Seventh International Conference on the Tear Film & Ocular Surface: Basic Science and Clinical Relevance (Taormina, Sicily, September 2013). Highlights from the Platform Sessions', The Ocular Surface, vol. 12, pp. 120 - 133, http://dx.doi.org/10.1016/j.jtos.2014.01.002
2014
Markoulli M; Papas EB; Cole NA; Holden BA, 2013, 'Effect of contact lens wear on the diurnal profile of matrix metalloproteinase 9 in tears', Optometry and Vision Science, vol. 90, pp. 419 - 429, http://dx.doi.org/10.1097/OPX.0b013e31828d7d3b
2013
Efron N; Jones L; Bron AJ; Knop E; Arita R; Barabino S; McDermott AM; Villani E; Willcox MDP; Markoulli M, 2013, 'The TFOS International Workshop on Contact Lens Discomfort: Report of the contact lens interactions with the ocular surface and adnexa subcommittee', Investigative Ophthalmology and Visual Science, vol. 54, http://dx.doi.org/10.1167/iovs.13-13187
2013
Wei EX; Markoulli M; Willcox MD; Zhao Z, 2012, 'Divalent cations in tears, and their influence on tear film stability in humans and rabbits', Investigative Ophthalmology and Visual Science, vol. 53, pp. 3280 - 3285, http://dx.doi.org/10.1167/iovs.12-9558
2012
Markoulli M; Papas EB; Cole NA; Holden BA, 2012, 'The diurnal variation of matrix metalloproteinase-9 and its associated factors in human tears', Investigative Ophthalmology and Visual Science, vol. 53, pp. 1479 - 1484, http://dx.doi.org/10.1167/iovs.11-8365
2012
Markoulli M, 2012, 'Tear film break-up time in rabbits.', Clinical and experimental optometry, vol. 96, pp. 70 - 75, http://dx.doi.org/10.1111/j.1444-0938.2012.00801.x
2012
Markoulli M; Papas EB; Petznick A; Holden BA, 2011, 'Validation of the flush method as an alternative to basal or reflex tear collection', Current Eye Research, vol. 36, pp. 198 - 207, http://dx.doi.org/10.3109/02713683.2010.542867
2011
Markoulli M; Francis I; Yong J; Jalbert I; O Hare N; Cole NA; Papas EB, 2011, 'A histopathological study of bulbar conjunctival flaps occurring in 2 contact lens wearers', Cornea, vol. 30, pp. 1037 - 1041, http://dx.doi.org/10.1097/ICO.0b013e318207ec82
2011
Markoulli M; Papas EB; Cole NA; Holden BA, 2011, 'Corneal erosions in contact lens wear', Contact Lens and Anterior Eye, vol. 35, pp. 2 - 8, http://dx.doi.org/10.1016/j.clae.2011.07.003
2011
Sankaridurg P; Markoulii M; de La Jara PL; Willcox MD; Harmis N; Thomas V; Holden BA, 2009, 'Lid and conjunctival microbiota during contact lens wear in children', Optometry and Vision Science, vol. 86, pp. 312 - 317, http://dx.doi.org/10.1097/OPX.0b013e318199d20c
2009
Herse PR; Hans A; Hall J; Langejans J; Markoulli M, 2005, 'The Proview Eye Pressure Monitor: influence of clinical factors on accuracy and agreement with the Goldmann tonometer', Ophthalmic and Physiological Optics, vol. 25, pp. 416 - 420, http://dx.doi.org/10.1111/j.1475-1313.2005.00302.x
2005