Michele Madigan

Associate Professor

RESEARCH

My research program is primarily directed at exploring and understanding the cell biology of human eye diseases in the context of normal human development and ageing. The challenge is to provide innovative approaches for human-tissue based ocular cell biology and the research program has evolved with changes in our understanding of disease pathogenesis, remaining uniquely human-tissue based.

Three main areas currently define my research program:

1. Understanding the microenvironment of primary ocular tumours, especially melanoma, and developing novel approaches for eye melanoma therapy. This includes studying normal human melanocytes (see image) (current PhD project).

2. Studying the normal ageing human retina and choroid, and age-related macular degeneration (AMD), the most common cause of blindness in those aged over 50 yrs.

3. Investigating the underlying pathogenesis of keratoconus (KC), a human corneal degeneration that is the major cause for corneal grafts.

We am currently funded for these research areas with grants from NH&MRC, Sydney Foundation for Medical Research (re-named National Foundation for Medical Research and Innovation in 2014) and the Ophthalmic Research Institute of Australia (ORIA), with well-established national and international collaborations in these areas.

  2014 NH&MRC  The role of redox-related post - translational changes of complement factor H (CFH) in age-related macular degeneration”  S Krilis, B Giannakopoulos, MC Madigan

  2013 NH&MRC Role of complement in retinal degeneration” K Volter, JM Provis, P Gatenby, MC Madigan

TEACHING

* involved in undergraduate courses VISN2111 Ocular Anatomy & Physiology (convenor), OPTM3231 Ocular Diseases and OPTM5251 Ocular Therapeutics and OPTM4291 Optometry, Medicine & Patient Management

* supervise students involved in MOptometry Coursework Research projects (OPTM7108 and 7308)

OTHER AFFILIATIONS

Clinical Associate Professor (Honorary), Discipline of Ophthalmology, Save Sight Institute, Sydney Medical School, University of Sydney

Visiting Fellow, John Curtin School of Medical Research, Australian National University

AWARDS

2013 Faculty of Science University of NSW Staff Excellence Award (Best Lecturer as voted by Students)

 

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Publications

Book Chapters
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Kingston Z; Provis JM; Madigan M, 2014, 'Development and Developmental Disorders of Vitreous', in Sebag J (ed.), Vitreous: In Health and Disease, Springer Publishing, New york, pp. 95 - 112,
2014
Yee KMP; Feener EP; Gao B; Aiello LP; Madigan M; Provis JM; Ross-Cisneros F; Sadun AA; Sebag J, 2014, 'Vitreous Cytokines and Regression of the Fetal Hyaloid Vasculature', in Sebag J (ed.), Vitreous: In Health and Disease, Springer Publishing, New york, pp. 41 - 56,
2014
Kingston ZS; Provis JM; Madigan MC, 2014, 'Development and developmental disorders of vitreous', in Vitreous: In Health and Disease, pp. 95 - 111,
2014
Yee KMP; Sebag J; Feener EP; Gao B; Aiello LP; Madigan MC; Provis J; Ross-Cisneros FN; Sadun AA, 2014, 'Vitreous cytokines and regression of the fetal hyaloid vasculature', in Vitreous: In Health and Disease, pp. 41 - 55,
2014
Provis J; Madigan MC, 2013, 'Foveal development and photoreceptor development', in Pediatric Retina: Second Edition
2013
Hao J; Madigan MC; Cozzi PJ; Kearsley J; Li Y; Hao J, 2011, 'Angiogenesis, Lymphangiogenesis and Vasculogenic Mimicry in Human Prostate Cancer Therapy', in Berhardt LV (ed.), Advances in Medicine and Biology, edn. Volume 38, Nova Science Publishers, Inc., New York, USA, pp. 49 - 90,
2011
Penfold PL; Wong J; van Driel D; Provis J; Madigan MC, 2005, 'Immunology & Age-Related Macular Degeneration', in Penfold PL; Provis JM (ed.), Macular Degeneration, edn. Original, Springer-Verlag,
2005
Conference Papers
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Sebag J; Yee K; Madigan MC; Aiello LP; Sadun AA, 2012, 'Bioinformatic Analysis of Embryonic Human Vitreomics', in investigative ophtalmology and vison science, association for research in vision and ophthalmology, fort lauderdale, pp. 4928, presented at association for research in vision and ophthalmology, fort lauderdale, 01 January 2012
2012
Hodges C; You JJ; Wen L; Roufas A; Madigan MC; Macvoy JW; Sutton G, 2012, 'WNT Signalling Pathway-Associated Proteins in Control and Keratoconus (KC) Tears and Corneas', in investigative ophtalmology and vison science, association for research in vision and ophthalmology, fort lauderdale, pp. E-Abstract 4221., presented at association for research in vision and ophthalmology, fort lauderdale, 01 January 2012
2012
Munoz-Erazo LE; Natoli R; Yeung AWS; Provis JM; Madigan MC; Thomas SR; King NJC, 2010, 'Microarray Analysis of Human Retinal Pigmented Epithelium Following Infection With West Nile Virus', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC,
2010
Feener E; Madigan MC; Provis J; Gao B; Sadun AA; Aiello LP; Sebag J, 2010, 'Comparative Proteome Analysis of the Developing and Adult Human Vitreous', in Investigative Ophthalmology and Visual Science, Association of Research Vision Ophthalmology Inc, Rockville, MD, USA, pp. 5096, presented at ARVO, Fort lauderdale, 01 May 2010
2010
Sebag J; Madigan MC; Feener E; Niemeyer M; Gao B; Aiello LP; Sadun AA; Provis J, 2010, 'Vitreous Protein Profiles During the Second Trimester of Human Embryogenesis', in Investigative Ophthalmology and Visual Science, Association of Research Vision Ophthalmology Inc, Rockville, MD, USA, pp. 5342, presented at ARVO, Fort Lauderdale, 01 May 2010
2010
Li Y; Wang J; Rizvi SM A; Jager MJ; Conway RM; Billson FA; Allen BJ; Madigan MC, 2006, 'In Vitro targeting of NG2 antigen by Bi-213-9.2.27 alpha-immunoconjugate induces cytotoxicity in human uveal melanoma cells', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH,
2006
Li Y; Wang JQ; Rizvi SM; Cozzi PJ; Madigan MC; Power C; Russell PJ; Allen BJ, 2006, 'Control of DU 145 and LNCaP-LN3 prostate cancer spheroid growth using 213Bi-labeled multiple targeted alpha radioimmunoconjugates', in Annals of Oncology, Oxford Univ Press, Oxford, England, pp. 47 - 47, presented at Symposium on targeted anticancer therapies, Amsterdam, 16 March 2006 - 18 March 2006,
2006
Li Y; Wang J; Zhang DY; Rizvi SMA; Lai K; Conway RM; Jager M; B illson FA; Allen BJ, 2004, 'In Vitro Targeting of NG2 antigen by 213Bi-9.2.27 radioimmunoconjugate induces cytotoxicity in human uveal melanoma cells', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, presented at XVI international congress of eye research, 29 August 2004 - 03 September 2004
2004
Conference Abstracts
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Zhang T; Zhu L; Madigan MC; Shen W; Bahrami B; Du J; Gillies MC, 2018, 'Comparison of Serine metabolism in Muller Cells from the Macula and Peripheral Retina', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Honolulu, HI, Vol. 59, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honolulu, HI, 29 April 2018 - 03 May 2018,
2018
You J; Wen L; Hodge C; Petsoglou C; Madigan M; Sutton G, 2015, 'A NEW WAY OF TISSUE CULTURING CORNEAL EPITHELIAL CELLS USING SILICONE GEL - APPLICATION ON KERATOCONUS CORNEAS', in CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, WILEY-BLACKWELL, Vol. 43, pp. 86 - 87,
2015
Syed F; Too LK; Madigan M; Cherepanoff S, 2015, 'MACROPHAGE AND MICROGLIA EXPRESSION OF HLA, CD68 AND CD163 IN NORMAL ADULT HUMAN EYES', in CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, WILEY-BLACKWELL, Vol. 43, pp. 122 - 122,
2015
Conference Presentations
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Hao JL; Madigan MC; Cozzi PJ; Khatri A; Power CA; Beretov J; Kearsley J; Li Y; Hao J, 2010, 'CD44 and CD147 expression influence prostate cancer chemoresistance and metastasis', presented at The Australian Society for Medical Research (ASMR), Sydney, Australia, -
2010
Journal articles
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Masri RA; Lee SCS; Madigan MC; Grünert U, 2019, 'Particle-mediated gene transfection and organotypic culture of postmortem human retina', Translational Vision Science and Technology, vol. 8,
2019
Ooi KG J; Rao A; Goh JS K; Gracie G; Cherepanoff S; Madigan MC; Watson SL, 2019, 'HMG-CoA reductase expression in human eyelid tissue and in a human meibomian gland epithelial cell line', Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 257, pp. 785 - 790,
2019
Masri RA; Lee SC S; Madigan MC; Grünert U, 2019, 'Particle-mediated gene transfection and organotypic culture of postmortem human retina', Translational Vision Science and Technology, vol. 8,
2019
Zhang T; Zhu L; Madigan MC; Liu W; Shen W; Cherepanoff S; Zhou F; Zeng S; Du J; Gillies MC, 2019, 'Human macular müller cells rely more on serine biosynthesis to combat oxidative stress than those from the periphery', eLife, vol. 8,
2019
Diep MQ; Madigan MC, 2019, 'Choroidal detachments: what do optometrists need to know?', Clinical and Experimental Optometry, vol. 102, pp. 116 - 125,
2019
Zhang T; Zhu L; Madigan MC; Liu W; Shen W; Cherepanoff S; Zhou F; Zeng S; Du J; Gillies MC, 2019, 'Human macular Müller cells rely more on serine biosynthesis to combat oxidative stress than those from the periphery', eLife, vol. 8,
2019
Ooi KGJ; Rao A; Goh JSK; Gracie G; Cherepanoff S; Madigan MC; Watson SL, 2019, 'HMG-CoA reductase expression in human eyelid tissue and in a human meibomian gland epithelial cell line', Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 257, pp. 785 - 790,
2019
Chu-Tan JA; Rutar M; Saxena K; Aggio-Bruce R; Essex RW; Valter K; Jiao H; Fernando N; Wooff Y; Madigan MC; Provis J; Natoli R, 2018, 'MicroRNA-124 dysregulation is associated with retinal inflammation and photoreceptor death in the degenerating retina', Investigative Ophthalmology and Visual Science, vol. 59, pp. 4094 - 4105,
2018
Cherepanoff S, 2018, 'Tumour Expression of Histone Deacetylases in Uveal Melanoma', Ocular Oncology and Pathology, pp. 1 - 9,
2018
Leahy KE; Madigan MC; Sarris M; Watson SL; McCluskey P; White AJR, 2018, 'Investigation of corneal endothelial changes post selective laser trabeculoplasty', Clinical and Experimental Ophthalmology, vol. 46, pp. 730 - 737,
2018
Krilis M; Qi M; Qi J; Wong JWH; Guymer R; Liew G; Hunyor AP; Madigan M; McCluskey P; Weaver J; Krilis SA; Giannakopoulos B, 2018, 'Dual roles of different redox forms of complement factor H in protecting against age related macular degeneration', Free Radical Biology and Medicine, vol. 129, pp. 237 - 246,
2018
Zhang T; Gillies MC; Madigan MC; Shen W; Du J; Grünert U; Zhou F; Yam M; Zhu L, 2018, 'Disruption of De Novo Serine Synthesis in Müller Cells Induced Mitochondrial Dysfunction and Aggravated Oxidative Damage', Molecular Neurobiology, vol. 55, pp. 7025 - 7037,
2018
Cioanca AV; McCluskey PJ; Eamegdool SS; Madigan MC, 2018, 'Human choroidal melanocytes express functional Toll-like receptors (TLRs)', Experimental Eye Research, vol. 173, pp. 73 - 84,
2018
You J; Munoz-Erazo L; Wen L; Hodge C; Madigan MC; Sutton G, 2018, 'In-Vitro Effects of Secreted Frizzled-Related Protein 1 (SFRP1) On Human Corneal Epithelial Cells', Current Eye Research, vol. 43, pp. 455 - 459,
2018
You J; Corley SM; Wen L; Hodge C; Höllhumer R; Madigan MC; Wilkins MR; Sutton G, 2018, 'RNA-Seq analysis and comparison of corneal epithelium in keratoconus and myopia patients', Scientific Reports, vol. 8,
2018
Lu YZ; Fernando N; Natoli R; Madigan M; Valter K, 2018, '670nm light treatment following retinal injury modulates Müller cell gliosis: Evidence from in vivo and in vitro stress models', Experimental Eye Research, vol. 169, pp. 1 - 12,
2018
Madigan MC, 2017, 'A novel zebrafish model for studying metastatic behavior of human conjunctival melanoma cells', Investigative Ophthalmology and Visual Science, vol. 58, pp. 6072,
2017
Lu YZ; Natoli R; Madigan M; Fernando N; Saxena K; Aggio-Bruce R; Jiao H; Provis J; Valter K, 2017, 'Photobiomodulation with 670 nm light ameliorates Müller cell-mediated activation of microglia and macrophages in retinal degeneration', Experimental Eye Research, vol. 165, pp. 78 - 89,
2017
Vader MJC; Madigan MC; Versluis M; Suleiman HM; Gezgin G; Gruis NA; Out-Luiting JJ; Bergman W; Verdijk RM; Jager MJ; Van Der Velden PA, 2017, 'GNAQ and GNA11 mutations and downstream YAP activation in choroidal nevi', British Journal of Cancer, vol. 117, pp. 884 - 887,
2017
Natoli R; Fernando N; Madigan M; Chu-Tan JA; Valter K; Provis J; Rutar M, 2017, 'Microglia-derived IL-1β promotes chemokine expression by Müller cells and RPE in focal retinal degeneration', Molecular Neurodegeneration, vol. 12,
2017
Natoli R; Fernando N; Jiao H; Racic T; Madigan M; Barnett NL; Chu-Tan JA; Valter K; Provis J; Rutar M, 2017, 'Retinal macrophages synthesize C3 and activate complement in AMD and in models of focal retinal degeneration', Investigative Ophthalmology and Visual Science, vol. 58, pp. 2977 - 2990,
2017
Krilis M; Qi M; Madigan MC; Wong JWH; Abdelatti M; Guymer RH; Whitelock J; McCluskey P; Zhang P; Qi J; Hunyor AP; Krilis SA; Giannakopoulos B, 2017, 'Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degeneration', Oncotarget, vol. 8, pp. 49016 - 49032,
2017
Angi M; Kalirai H; Prendergast S; Simpson D; Hammond DE; Madigan MC; Beynon RJ; Coupland SE, 2016, 'In-depth proteomic profiling of the uveal melanoma secretome', Oncotarget, vol. 7, pp. 49623 - 49635,
2016
You J; Wen L; Roufas A; Hodge C; Sutton G; Madigan MC, 2016, 'Expression of HGF and c-Met Proteins in Human Keratoconus Corneas (vol 2015, 852986, 2015)', JOURNAL OF OPHTHALMOLOGY, vol. 2016,
2016
Milston R; Madigan MC; Sebag J, 2016, 'Vitreous floaters: Etiology, diagnostics, and management', Survey of Ophthalmology, vol. 61, pp. 211 - 227,
2016
Natoli R; Rutar M; Lu YZ; Chu-Tan JA; Chen Y; Saxena K; Madigan M; Valter K; Provis JM, 2016, 'The Role of Pyruvate in Protecting 661W Photoreceptor-Like Cells Against Light-Induced Cell Death', Current Eye Research, vol. 41, pp. 1473 - 1481,
2016
You J; Wen L; Roufas A; Hodge C; Sutton G; Madigan MC, 2016, 'Corrigendum to "Expression of HGF and c-Met Proteins in Human Keratoconus Corneas".', J Ophthalmol, vol. 2016, pp. 4201505,
2016
Xu C; Zhu L; Chan T; Lu X; Shen W; Madigan MC; Gillies MC; Zhou F, 2016, 'Chloroquine and Hydroxychloroquine Are Novel Inhibitors of Human Organic Anion Transporting Polypeptide 1A2', Journal of Pharmaceutical Sciences, vol. 105, pp. 884 - 890,
2016
Zhang P; Weaver JC; Chen G; Beretov J; Atsumi T; Qi M; Bhindi R; Qi JC; Madigan MC; Giannakopoulos B; Krilis SA, 2016, 'The fifth domain of beta 2 glycoprotein I protects from natural IgM mediated cardiac ischaemia reperfusion injury', PLoS ONE, vol. 11,
2016
Qi M; Abdelatti M; Krilis M; Madigan MC; Weaver J; Guymer RH; McCluskey P; Wang Y; Zhou S; Krilis SA; Giannakopoulos B, 2016, 'Do Beta 2-Glycoprotein i Disulfide Bonds Protect the Human Retina in the Setting of Age-Related Macular Degeneration?', Antioxidants and Redox Signaling, vol. 24, pp. 32 - 38,
2016
Chan-Ling T; Koina ME; Arfuso F; Adamson SJ; Baxter LC; Hu P; Madigan MC, 2015, 'Author Response: Sufficient Evidence for Lymphatics in the Developing and Adult Human Choroid?', INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 56, pp. 6711 - 6713,
2015
Chan T; Zhu L; Madigan MC; Wang K; Shen W; Gillies MC; Zhou F, 2015, 'Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all-trans-retinol in human retinal pigmented epithelial cells', British Journal of Pharmacology, vol. 172, pp. 2343 - 2353,
2015
Chan T; Zhu L; Madigan MC; Wang K; Shen W; Gillies MC; Zhou F, 2015, 'Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all-trans-retinol in human retinal pigmented epithelial cells', British Journal of Pharmacology, vol. 172, pp. 2343 - 2353,
2015
Yee KMP; Feener EP; Madigan M; Jackson NJ; Gao BB; Ross-Cisneros FN; Provis J; Aiello LP; Sadun AA; Sebag J, 2015, 'Proteomic analysis of embryonic and young human vitreous', Investigative Ophthalmology and Visual Science, vol. 56, pp. 7036 - 7042,
2015
Quin GJ; Lyons B; Len AC; Madigan MC; Gillies MC, 2015, 'Proteome changes induced by laser in diabetic retinopathy', Clinical and Experimental Ophthalmology, vol. 43, pp. 180 - 187,
2015
Chan-Ling T; Koina ME; Arfuso F; Adamson SJ; Baxter LC; Hu P; Madigan MC, 2015, 'Author Response: Sufficient Evidence for Lymphatics in the Developing and Adult Human Choroid?', Invest Ophthalmol Vis Sci, vol. 56, pp. 6711 - 6713,
2015
Koina ME; Baxter L; Adamson SJ; Arfuso F; Hu P; Madigan MC; Chan-Ling T, 2015, 'Evidence for lymphatics in the developing and adult human choroid', Investigative Ophthalmology and Visual Science, vol. 56, pp. 1310 - 1327,
2015
Milston R; Madigan MC; Sebag J, 2015, 'Vitreous floaters: Etiology, diagnostics, and management', Survey of Ophthalmology,
2015
You J; Wen L; Roufas A; Hodge C; Sutton G; Madigan MC, 2015, 'Expression of HGF and c-met proteins in human keratoconus corneas', Journal of Ophthalmology, vol. 2015,
2015
Wen L; Zhu M; Madigan MC; You J; King NJC; Billson FA; McClellan K; Sutton G; Petsoglou C, 2014, 'Immunomodulatory effects of bone marrow-derived mesenchymal stem cells on pro-inflammatory cytokine-stimulated human corneal epithelial cells', PLoS ONE, vol. 9,
2014
Munoz-Erazo L; Madigan M; Conway RM, 2014, 'Gene expression in conjunctival melanoma cell lines treated with the histone deacetylase (HDAC) inhibitor valproic acid (VPA)', ACTA OPHTHALMOLOGICA, vol. 92,
2014
Quah XM; Conway RM; Madigan MC; Epstein RJ, 2014, 'Emerging strategies for therapeutic targeting of the tumour microenvironment', Cancer Forum, vol. 38, pp. 133 - 137
2014
Munoz-Erazo L; Madigan M; King NJC, 2014, 'Cytokine gene expression and protein production in West Nile virus-infected retinal pigment epithelium', ACTA OPHTHALMOLOGICA, vol. 92,
2014
Madigan M; Quah X; Mcalpine S; Conway RM, 2014, 'HSP90 inhibitors and conjunctival melanoma', ACTA OPHTHALMOLOGICA, vol. 92,
2014
You J; Hodge C; Wen L; McAvoy JW; Madigan MC; Sutton G, 2013, 'Tear levels of SFRP1 are significantly reduced in keratoconus patients', Molecular Vision, vol. 19, pp. 509 - 515
2013
You J; Wen L; Roufas A; Madigan MC; Sutton G, 2013, 'Expression of SFRP Family Proteins in Human Keratoconus Corneas', PLoS ONE, vol. 8,
2013
Krilis M; Mao Q; Madigan M; Wong J; Abulatti M; Guymer R; McCluskey P; Zhang P; Qi J; Krilis S; Giannakopoulos B, 2013, 'POST TRANSLATIONALLY MODIFIED COMPLEMENT FACTOR H IN AGE RELATED MACULAR DEGENERATION', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, vol. 41, pp. 17 - 17,
2013
Baxter L; Koina M; Adamson S; Arfuso F; Hu P; Vestweber D; Alitalo K; Madigan M; Chan-Ling T, 2013, 'COMPELLING EVIDENCE FOR EXISTENCE OF LYMPHATICS IN THE HUMAN CHOROID: NORMAL DEVELOPMENTAL PROCESSES & RELEVANCE TO DIABETES & CANCER', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, vol. 41, pp. 134 - 134,
2013
Petznick A; Madigan MC; Garrett Q; Sweeney DF; Evans MD, 2013, 'Contributions of ocular surface components to matrix-metalloproteinases (MMP)-2 and MMP-9 in feline tears following corneal epithelial wounding.', PloS one, vol. 8,
2013
Dastjerdi SS; Madigan M; Koina ME; Chan-Ling T, 2013, 'CHANGES IN BIOENERGETICS OF THE HUMAN PHOTORECEPTOR/RPE/CHORIOCAPPILLARIS COMPLEX DURING 'PHYSIOLOGICAL' AGING CONTRIBUTE TO RETINAL PATHOLOGY', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, vol. 41, pp. 128 - 128,
2013
Petznick A; Madigan MC; Garrett Q; Sweeney DF; Evans MD, 2013, 'Contributions of ocular surface components to matrix-metalloproteinases (MMP)-2 and MMP-9 in feline tears following corneal epithelial wounding.', PloS one, vol. 8,
2013
You J; Willcox MD; Madigan MC; Wasinger V; Schiller B; Walsh BJ; Graham PH; Kearsley JH; Li Y, 2013, 'Tear Fluid Protein Biomarkers', Advances in Clinical Chemistry, vol. 62, pp. 151 - 196,
2013
Lim L-A; Madigan MC; Conway RM, 2013, 'Conjunctival melanoma: A review of conceptual and treatment advances', Clinical Ophthalmology, vol. 7, pp. 521 - 531,
2013
You JJ; Hodges C; Wen L; McAvoy JW; Madigan MC; Sutton G, 2012, 'Using soybean trypsin inhibitor as an external loading control for Western blot analysis of tear proteins: application to corneal disease.', Experimental Eye Research, vol. 99, pp. 55 - 62,
2012
Petznick A; Evans MD; Madigan MC; Garrett Q; Sweeney DF, 2012, 'A preliminary study of changes in tear film proteins in the feline eye following nictitating membrane removal', Veterinary Ophthalmology, vol. 15, pp. 164 - 171,
2012
You JJ; Madigan MC; Rowe A; Sajinovic M; Russell PJ; Jackson P, 2012, 'An inverse relationship between KAI1 expression, invasive ability, and MMP-2 expression and activity in bladder cancer cell lines.', Urologic Oncology - Seminars and Original Investigations, vol. 30, pp. 502 - 508,
2012
Munoz-Erazo L; Natoli R; Provis JM; Madigan MC; King NJC, 2012, 'Microarray analysis of gene expression in West Nile virus-infected human retinal pigment epithelium', Molecular Vision, vol. 18, pp. 730 - 743
2012
Chan-Ling T; Koina M; Baxter L; Hu P; Arfuso F; Adamson S; Dahlstrom J; Alitalo K; Madigan M, 2012, 'COMPELLING EVIDENCE FOR LYMPHATICS IN THE DEVELOPING AND ADULT HUMAN CHOROID', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, vol. 40, pp. 128 - 128,
2012
Hao J; Madigan MC; Khatri A; Power C; Hung TT; Beretov J; Chang L; Xiao W; Cozzi PJ; Graham PH; Kearsley J; Li Y, 2012, 'In Vitro and In Vivo Prostate Cancer Metastasis and Chemoresistance Can Be Modulated by Expression of either CD44 or CD147', PLoS One, vol. 7, pp. 1 - 14,
2012
Errington JA; Conway RM; Walsh-conway N; Browning J; Freyer C; Cebon J; Madigan MC, 2012, 'Expression of cancer-testis antigens (MAGE-A1, MAGE-A3/6, MAGE-A4, MAGE-C1 and NY-ESO-1) in primary human uveal and conjunctival melanoma', British Journal of Ophthalmology, vol. 96, pp. 451 - 458,
2012
Beaumont P; Madigan MC; Mathew RS, 2011, 'Crisis in optometric screening of diabetic retinopathy: illusion or reality.', Clinical and Experimental Ophthalmology, vol. 39, pp. 193 - 194,
2011
Mathew RS; Delbaere K; Lord SR; Beaumont P; Vaegan ; Madigan MC, 2011, 'Depressive symptoms and qualityof life in people with age-related macular degeneration', Ophthalmic and Physiological Optics, vol. 31, pp. 375 - 380,
2011
Wang L; Chen H; Liu F; Madigan MC; Power C; Hao J; Patterson K; Pourgholami MH; O Brien P; Perkins A; Li Y, 2011, 'Monoclonal antibody targeting MUC1 and increasing sensitivity to docetaxel as a novel strategy in treating human epithelial ovarian cancer', Cancer Letters, vol. 300, pp. 122 - 133,
2011
You J; Wen L; Hodges C; Madigan M; McAvoy J; Sutton G, 2011, 'Wnt SIGNALLING PATHWAY-ASSOCIATED PROTEINS IN TEARS FROM CONTROL AND KERATOCONUS (KC) PATIENTS', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, vol. 39, pp. 80 - 80,
2011
Romo P; Madigan MC; Provis J; Cullen K, 2011, 'Differential effects of TGF-β and FGF-2 on in vitro proliferation and migration of primate retinal endothelial and Müller cells.', ACTA Ophthalmologica Scandinavica, vol. 89, pp. e263 - e268,
2011
Jager M; Ly L; El Filali M; Madigan MC, 2011, 'Macrophages in uveal melanoma and in experimental ocular tumor models: Friends or foes?', Progress in Retinal and Eye Research, vol. 30, pp. 129 - 146
2011
Shu D; Go R; Munoz-Erazo L; Madigan M; Conway M, 2011, 'EXPRESSION OF HISTONE DEACETYLASES IN HUMAN CHOROIDAL MELANOCYTES, AND CONJUNCTIVAL AND UVEAL MELANOMA', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, vol. 39, pp. 77 - 78,
2011
Munoz-Erazo L; Yeung A; Madigan M; Thomas S; King N, 2011, 'BALANCE OF INDOLEAMINE 2,3 DIOXYGENASE AND INDUCIBLE NITRIC OXIDE SYNTHASE RESPONSES IN WEST NILE VIRUS-INFECTED HUMAN RETINAL PIGMENT EPITHELIUM', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, vol. 39, pp. 87 - 87,
2011
Kaneko H; Dridi S; Tarallo V; Gelfand BD; Fowler BJ; Cho WG; Kleinman ME; Poniscan SL; Hauswirth WW; Chiodo VA; Kariko K; Yoo JW; Lee D; Hadziahmetovic M; Song Y; Misra S; Chaudhuri G; Buaas FW; Braun R; Hinton DR; Zhang Q; Grossniklaus HE; Provis J; Madigan MC; Milam AH; Justice NL; Albuquerque RJC; Blandford AD; Bogdanovich S; Hirano Y; Witta J; Fuchs E; Littman DR; Ambati BK; Rudin CM; Chong MMW; Provost P; Kugel JF; Goodrich J; Dunaief JL; Baffi JZ; Ambati J, 2011, 'DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration', Nature, vol. 471, pp. 325 - 332,
2011
Mathew R; Delbaere K; Madigan M; Beaumont P; Vaegan ; Lord S, 2011, 'DEPRESSIVE SYMPTOMS AND QUALITY OF LIFE IN PEOPLE WITH AGE-RELATED MACULAR DEGENERATION', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, vol. 39, pp. 82 - 82,
2011
Hao JL; Chen H; Madigan MC; Cozzi PJ; Beretov J; Xiao W; Delprado W; Russell PJ; Li Y, 2010, 'Co-expression of CD147 (EMMPRIN), CD44v3-10, MDR1 and monocarboxylate transporters is associated with prostate cancer drug resistance and progression.', British Journal of Cancer, vol. 103, pp. 1008 - 1018,
2010
Kozulin P; Natoli R; Bumsted O Brien K; Madigan MC; Provis J, 2010, 'The cellular expression of antiangiogenic factors in fetal primate macula.', Investigative Ophthalmology and Visual Science, vol. 51, pp. 4298 - 4306,
2010
Kozulin P; Natoli R; Bumsted O Brien K; Madigan MC; Provis J, 2009, 'Differential expression of anti-angiogenic factors and guidance genes in the developing macula', Molecular Vision, vol. 15, pp. 45 - 59
2009
Wang LL; Madigan MC; Chen H; Liu F; Patterson K; Beretov J; O Brien P; Li Y, 2009, 'Expression of urokinase plasminogen activator and its receptor in advanced epithelial ovarian cancer patients', Gynecologic Oncology, vol. 114, pp. 265 - 272,
2009
Cunneen TS; Conway RM; Madigan MC, 2009, 'In vitro effects of histone deacetylase inhibitors and mitomycin C on tenon capsule fibroblasts and conjunctival melanoma cells', Archives of Ophthalmology, vol. 127, pp. 414 - 420,
2009
Davies S; Chui JJ; Madigan MC; Provis J; Wakefield D; Di Girolamo N, 2009, 'Stem cell activity in the developing human cornea', Stem Cells, vol. 27, pp. 2781 - 2792,
2009
Shelley E; Madigan MC; Natoli R; Penfold PL; Provis J, 2009, 'Cone degeneration in aging and age-related macular degeneration.', Archives of Ophthalmology, vol. 127, pp. 414 - 420
2009
Kozulin P; Natoli R; Madigan MC; O brien KM; Provis J, 2009, 'Gradients of Eph-A6 expression in primate retina suggest roles in both vascular and axon guidance', Molecular Vision, vol. 15, pp. 2649 - 2662
2009
Shah HR; Conway RM; Van Quill KR; Madigan MC; Howard SA; Qi J; Weinberg V; O Brien JM, 2008, 'Beta-Iapachone inhibits proliferation and induces apoptosis in retinoblastoma cell lines', Eye, vol. 22, pp. 454 - 460,
2008
Madigan MC; Kingsley EA; Cozzi PJ; Delprado W; Russell PJ; Li Y, 2008, 'The role of extracellular matrix metalloproteinase inducer protein in prostate cancer progression', Cancer Immunology and Immunotherapy, vol. 57, pp. 1367 - 1379,
2008
Lai K; Conway RM; Crouch RL; Jager M; Madigan MC, 2008, 'Expression and distribution of MMPs and TIMPs in human uveal melanoma', Experimental Eye Research, vol. 86, pp. 936 - 941
2008
Lai K; Di Girolamo N; Conway RM; Jager M; Madigan MC, 2007, 'The effect of ultraviolet radiation on choroidal melanocytes and melanoma cell lines: cell survival and matrix metalloproteinase production', Graefes Archive for Clinical and Experimental Ophthalmology, vol. 245, pp. 715 - 724,
2007
Lai K; Sharma V; Jager M; Conway RM; Madigan MC, 2007, 'Expression and distribution of MUC18 in human uveal melanoma', Virchows Archiv, vol. 451, pp. 967 - 976
2007
Cozzi PJ; Wang JQ; Delprado W; Madigan MC; Fairy S; Russell PJ; Li Y, 2006, 'Evaluation of urokinase plasminogen activator and its receptor in different grades of human prostate cancer', Human Pathology, vol. 37, pp. 1442 - 1451,
2006
Allende A; Madigan MC; Provis J, 2006, 'Endothelial cell proliferation in the choriocapillaris during human retinal differentiation', British Journal of Ophthalmology, vol. 90, pp. 1046 - 1051
2006
Wang JQ; Abbas Rizvi SM; Madigan MC; Cozzi PJ; Morgenstern A; Qu CF; Apostolidis C; Russell PJ; Allen BJ; Li Y, 2006, 'Control of prostate cancer spheroid growth using (213)Bi-labeled multiple targeted alpha radioimmunoconjugates', Prostate, vol. 66, pp. 1753 - 1767
2006
Georges P; Cornish EE; Provis J; Madigan MC, 2006, 'Muller cell expression of glutamate cycle related proteins and anti-apoptotic proteins in early human retinal development', British Journal of Ophthalmology, vol. 90, pp. 223 - 228
2006
Wang J; Rizvi SM; Madigan MC; Cozzi PJ; Power C; Qu CF; Morgenstern A; Apostolidis C; Russell PJ; Allen BJ; Li Y, 2006, 'Control of prostate cancer spheroid growth using 213Bi-labeled multiple targeted alpha radioimmunoconjugates.', Prostate, vol. 66, pp. 1753 - 1767,
2006
Russell PJ; Cozzi PJ; Wang J; Delprado W; Madigan MC; Fairy S; Li Y, 2006, 'Evaluation of urokinase plasminogen activator and its receptor in different grades of prostate cancer: Potential therapeutic targets.', Human Pathology, vol. 37, pp. 1442 - 1451
2006
Qi J; Wang JQ; Mandadi S; Tanaka K; Roufogalis BD; Madigan MC; Lai K; Yan F; Chong BH; Stevens RL; Krilis S, 2006, 'Human and mouse mast cells use the Tetraspanin CD9 as an alternate Interleukin 16 receptor', Blood, vol. 107, pp. 135 - 142,
2006
Pham TV; Madigan MC; McCluskey PJ; Penfold PL, 2005, 'Human retinal microglia express candidate receptors for HIV-1 infection', British Journal of Ophthalmology, vol. 89, pp. 753 - 757
2005
Provis J; Penfold PL; Cornish EE; Sandercoe TM; Madigan MC, 2005, 'Anatomy and development of the macula: Specialization and vulnerability to macular degeneration', Clinical and Experimental Optometry, vol. 88, pp. 269 - 281
2005
Cornish EE; Madigan MC; Natoli R; Hales A; Hendrickson AE; Provis J, 2005, 'Gradients of cone differentiation and FGF expression during development of the foveal depression in macaque retina', Visual Neuroscience, vol. 22, pp. 447 - 459
2005
Cole N; Hume E; Khan S; Madigan M; Husband AJ; Garthwaite L; Willcox M, 2005, 'Contribution of the cornea to cytokine levels in the whole eye induced during the early phase of Pseudomonas aeruginosa challenge', Immunology and Cell Biology, vol. 83, pp. 301 - 306,
2005
Pham VT; Wen LM; McCluskey PJ; Madigan MC; Penfold PL, 2005, 'Human retinal microglia express candidate receptors for HIV-1 infection', British Journal of Ophthalmology, vol. 89, pp. 753 - 757
2005
Tretiach ML; Wen L; Madigan MC; Gillies MC, 2005, 'Effect of Muller Cell co-culture on in vitro permeability of bovine retinal vascular endothelium in normoxic and hypoxic conditions', Neuroscience Letters, vol. 378, pp. 160 - 165
2005
Li Y; Wang JQ; Rizvi SM; Conway RM; Billson FA; Allen BJ; Madigan MC, 2005, 'In vitro targeting of NG2 antigen by 213Bi-9.2.27 alpha-immunoconjugate induces cytotoxicity in human uveal melanoma cells', Investigative Ophthalmology and Visual Science, vol. 46, pp. 4365 - 4371,
2005
Tretiach ML; Madigan MC; Gillies MC, 2004, 'Conditioned medium from mixed retinal pigmented epithelium and Muller cell cell cultures reduces in vitro permeability of retinal vascular endothelial cells', British Journal of Ophthalmology, vol. 88, pp. 957 - 961
2004
Li L; Li Y; Krilis S; Qi JC; Moore CH; Madigan MC; Katsoulotos GP, 2003, 'An antibody raised against in-vitro-derived human mast cells identifies mature mast cells and a population of cells that are Fc...., Tryptase, and chymase in a variety of human tissues', Journal of Histochemistry and Cytochemistry, vol. 51, pp. 643 - 653,
2003
Wu KHC; Madigan MC; Billson FA; Penfold PL, 2003, 'Differential expression of GFAP in early vs late AMD: A quantitative analysis', British Journal of Ophthalmology, vol. 87, pp. 1159 - 1166
2003
Li Y; Madigan MC; Conway RM; Billson FA; Crouch RL; Allen BJ, 2003, 'Human uveal melanoma expresses NG2 immunoreactivity', British Journal of Ophthalmology, vol. 87, pp. 629 - 632,
2003
Evans MDM; Xie RZ; Fabbri M; Madigan MC; Chaouk H; Beumer GJ; Meijs GF; Griesser HJ; Steele JG; Sweeney DF, 2000, 'Epithelialization of a synthetic polymer in the feline cornea: A preliminary study', Investigative Ophthalmology and Visual Science, vol. 41, pp. 1674 - 1680
2000
Evans MD; Xie RZ; Fabbri M; Madigan MC; Chaouk H; Beumer GJ; Meijs GF; Griesser HJ; Steele JG; Sweeney DF, 2000, 'Epithelialization of a synthetic polymer in the feline cornea', Investigative Ophthalmology and Visual Science, pp. 1674 - 1680
2000
Ibarra MS; Madigan M; Uusitalo M; Smith J; O'Brien J, 1999, 'Efficacy of the differentiating agent sodium butyrate in a murine transgenic model of retinoblastoma', INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 40, pp. S647 - S647,
1999
Madigan MC; Holden BA, 1992, 'Reversible endothelial changes in the monkey cornea', Cornea, vol. 11, pp. 319 - 325,
1992
Madigan MC; Holden BA, 1992, 'Reduced epithelial adhesion after extended contact lens wear correlates with reduced hemidesmosome density in cat cornea', Investigative Ophthalmology and Visual Science, vol. 33, pp. 314 - 323
1992
Madigan MC; Penfold PL; Holden BA; Billson FA, 1990, 'Ultrastructural features of contact lens-induced deep corneal neovascularization and associated stromal leukocytes.', Cornea, vol. 9, pp. 144 - 151,
1990
Madigan MC; Holden BA; Kwok LS, 1987, 'Extended wear of contact lenses can compromise corneal epithelial adhesion', Current Eye Research, vol. 6, pp. 1257 - 1260,
1987
KIELY PM; CREWTHER SG; NATHAN J; BRENNAN NA; EFRON N; MADIGAN M, 1987, 'A COMPARISON OF OCULAR DEVELOPMENT OF THE CYNOMOLGUS MONKEY AND MAN', CLINICAL VISION SCIENCES, vol. 1, pp. 269 - 280,
1987
Madigan MC; Gillard-Crewther S; Kiely PM; Crewther DP; Brennan NA; Efron N; Holden BA, 1987, 'Corneal thickness changes following sleep and overnight contact Lens wear in the primate (macaca fascicularis)', Current Eye Research, vol. 6, pp. 809 - 815,
1987
Kwok LS; Madigan M, 1986, 'A new analysis of wound closure kinematics in the cat and rabbit corneal epithelium', Clinical and Experimental Optometry, vol. 69, pp. 4 - 12,
1986