Nicole Carnt

Scientia Fellow and Senior Lecturer
Senior Lecturer

About Me:
I graduated from University of NSW in Optometry in 1989 and worked in private practice for 10 years before taking a position with the Brien Holden Vision Institute in 1999, where I held a variety of roles, including Principal Investigator on contact lens clinical trials. I completed a PhD on Epidemiology of Contact Lens Related Infection and Inflammation 2008-12, while working part time as a project manager at UNSW. I was awarded a NHMRC CJ Martin Biomedical Fellowship Early Career Fellowship in 2012 and spent the first 2.5 years at Moorfields Eye Hospital, London, Europe’s largest tertiary eye hospital. Recently I worked with Clinical Associate Professor Andrew White and Professor Tony Cunningham at Westmead Institute for Medical Research primarily in the area of the host immune response to keratitis. I also remain affiliated with Moorfields Eye Hospital and University College London.

TEACHING AND SUPERVISION
  • Vision science
  • Optometry
  • Microbiology
  • Immunology
  • Eye Infection and inflammation
Honorary Research Appointments:
  • University College London
  • Moorfields Eye Hospital, London
  • Westmead Institute for Medical Research

IN THE MEDIA
Moorfields Eye Hospital NHS Foundation Trust Social Media Campaign: Healthy Contact lens wear (www.moorfields.nhs.uk/landing-page/healthy-habits-healthy-eyes)

INTERNATIONAL LINKS

(UCL Institute of Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, UCL/Moorfields Biomedical Research Centre) Investigation of the host genetic immune response to Acanthamoeba Keratitis, diagnosis of bacterial keratitis, genetics of corneal dystrophies and patient involvement in research initiatives. 

Publications

Conference Papers
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Carnt NI C O L E; Dutta D; Mistry P; La Rode D; Badenoch P; Kilvington S, 2018, 'A pilot study of the distribution of Acanthamoeba species in Sydney domestic sinks', in A pilot study of the distribution of Acanthamoeba species in Sydney domestic sinks, Scientific and Educators' Meeting in Optometry, Melbourne, presented at Scientific and Educators' Meeting in Optometry, Melbourne, 05 April 2018 - 06 April 2018
2018
Carnt NA; Robaei D; Minassian D; Dart JK G, 2017, 'Acanthamoeba keratitis in 194 patients: risk factors for poor outcomes and severe inflammatory complications', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Baltimore, MD, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Baltimore, MD, 07 May 2017 - 11 May 2017,
2017
Keay LJ; Vu QD; Palagyi A; McCluskey PJ; White AJ R; Carnt N; Stapleton F; Laba T-L, 2017, 'Deciding where to access cataract surgery: a discrete choice experiment in Australia', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Baltimore, MD, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Baltimore, MD, 07 May 2017 - 11 May 2017,
2017
Evans C; Davidson A; Carnt N; Veli N; Tuft SJ; Hardcastle A, 2015, 'Investigation of genotype-phenotype correlation of TGFBI mutations reveals c.1868G > A; p.(Gly623Asp) is associated with a variable clinical phenotype, including epithelial basement membrane dystrophy', in ACTA OPHTHALMOLOGICA, WILEY-BLACKWELL,
2015
2015, 'Investigation of genotype-phenotype correlation of TGFBI mutations reveals c.1868G > A; p.(Gly623Asp) is associated with a variable clinical phenotype, including epithelial basement membrane dystrophy', in ACTA OPHTHALMOLOGICA, WILEY-BLACKWELL,
2015
Carnt NA; Robaei D; Minassian D; Dart JK G, 2014, 'Topical steroid use prior to diagnosis exacerbates Acanthamoeba keratitis.', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC,
2014
Stapleton F; Naduvilath T; Keay LJ; Radford CF; Dart IK; Edwards K; Carnt N; Minassian D; Holden B, 2010, 'Risk Factors for Microbial Keratitis in Daily Disposable Contact Lens Wear', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC,
2010
Willcox MD; Diec I; Carnt N; Evans V; Nadvilath T; Iskandar S; Zhu H; Holden BA, 2010, 'Contact Lens Case Contamination During Daily Wear of a Silicone Hydrogel Lens', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC,
2010
2010, 'Risk Factors for Microbial Keratitis in Daily Disposable Contact Lens Wear', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC
2010
2010, 'Contact Lens Case Contamination During Daily Wear of a Silicone Hydrogel Lens', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC
2010
O Hare N; Sweeney DF; Stern J; Willcox MD; Wong PR, 2002, 'Factors associated with unusual cases of acute infiltrative keratitis in silicone hydrogel extended wear', in Investigative Ophthalmology and Visual Science, Association of Research Vision Ophthalmology Inc, Rockville, MD, USA, pp. 3111 - 3111, presented at ARVO 2002: Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida, 01 May 2002
2002
O Hare N; Holden BA; Sweeney DF, 2002, 'SEALs and High Dk silicone hydrogel contact lenses', in Clinical and Experimental Ophthalmology, Blackwell Publishing Asia, Carlton, Victoria, Australia, pp. 28 - 28, presented at XXIXth International Congress of Ophthalmology, Darling Harbour, Sydney, 01 April 2002
2002
O Hare N; McKenzie J; Abraham A; Dimond F; Holden BA, 2001, 'Low cost spectacles: Acceptance in a developing nation', in Optometry and Vision Science, Lippincott Williams & Wilkins, Philadelphia, PA, pp. 131 - 131, presented at American Academy of Optometry (2001), Philadelphia, Pennsylvania, 06 December 2001 - 10 December 2001
2001
Stern J; O Hare N; Sweeney DF; Wong PR; Holden BA, 2000, 'Comparison of contact lens surface characteristics and subjective comfort ratings with high Dk soft lenses used on a six and thirty night extended schedule', in Optometry and Vision Science, Lippincott Williams & Wilkins, Philadelphia, PA, pp. 21 - 21, presented at American Academy of Optometry (2000), Orlando, Florida, USA, 01 December 2000
2000
Stern J; O Hare N; Sweeney DF; Wong PR; Holden BA, 2000, 'Comparison of contact lens surface characteristics and subjective comfort ratings with high Dk soft lenses used on a six and thirty night extended schedule', in Australian and New Zealand Journal of Ophthalmology, Blackwell Science Asia, South Carlton, Australia, pp. 111 - 111, presented at Australasian Ophthalmic and Visual Sciences Meeting 2000, Sydney, 01 December 2000
2000
Pearce DJ; Tan ME; O Hare N; Skotnitsky C; Willcox MD, 2000, 'Surface protein profile of extended-wear hydrogel lenses from asymptomatic and adverse response subjects', in Cornea, Lippincott Williams & Wilkins, Philadelphia, PA, pp. S113 - S113, presented at 3rd international conference on the Lacrimal Gland, tear film and dry eye syndromes, Maui, Hawaii, 15 November 2000 - 18 November 2000
2000
O Hare N; Sweeney DF; Wong PR; Skotnitsky C; Holden BA, 2000, 'How previous lens wear history affects comfort in high Dk lens wear', in Optometry and Vision Science, Lippincott Williams & Wilkins, Philadelphia, PA, pp. 120 - 120, presented at American Academy of Optometry (2000), Orlando, Florida, USA, 01 December 2000
2000
O Hare N; Sweeney DF; Wong PR; Skotnitsky C; Holden BA, 2000, 'Lens fitting and surface characteristics associated with comfort in high Dk EW', in Australian and New Zealand Journal of Ophthalmology, Blackwell Science Asia, South Carlton, Australia, pp. 95 - 95, presented at Australasian Ophthalmic and Visual Sciences Meeting 2000, Sydney, 01 December 2000
2000
Holden BA; Sweeney DF; Sankaridurg P; O Hare N, 2000, 'Extended wear: Overview', in Scottish Contact Lens Society Annual Conference, Scottish Contact Lens Society Annual Conference, Edinburgh, Scotland, presented at Scottish Contact Lens Society Annual Conference, Edinburgh, Scotland, 01 March 2000
2000
Holden BA; Sankaridurg P; Sweeney DF; Willcox MD; O Hare N, 2000, 'Extended wear research and adverse responses', in Scottish Contact Lens Society Annual Conference, Scottish Contact Lens Society Annual Conference, Edinburgh, Scotland, presented at Scottish Contact Lens Society Annual Conference, Edinburgh, Scotland, 01 March 2000
2000
O Hare N, 1999, 'Evaluating the performance of soft toric lenses', in 10th International Contact Lens Conference, 10th International Contact Lens Conference, Auckland, New Zealand, presented at 10th International Contact Lens Conference, Auckland, New Zealand, 01 September 1999
1999
Conference Abstracts
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Evans CJ; Davidson AE; Carnt N; Veli N; Tuft SJ; Hardcastle AJ, 2016, 'The mutational spectrum of anterior corneal dystrophies in the UK', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Seattle, WA, Vol. 57, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Seattle, WA, 01 May 2016 - 05 May 2016,
2016
Heyworth A; Di Girolamo N; Carnt N; Keay L; Watson S, 2016, 'CLINICAL FEATURES AND DEMOGRAPHICS OF PATIENTS WITH LIMBAL STEM CELL DEFICIENCY ATTENDING CORNEAL OUTPATIENT CLINICS AT SYDNEY EYE HOSPITAL', in CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, WILEY-BLACKWELL, Vol. 44, pp. 89 - 89,
2016
Robaei D; Carnt NA; Dart JK, 2013, 'ACANTHAMOEBA KERATITIS IN THE UK - A CASE SERIES OF 196 PATIENTS', in CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, WILEY-BLACKWELL, Vol. 41, pp. 28 - 29,
2013
Carnt NA; Sweeney DF; Stern J; Willcox M; Wong R, 2002, 'Factors associated with unusual cases of acute infiltrative keratitis in silicone hydrogel extended wear', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, FT LAUDERDALE, FLORIDA, Vol. 43, pp. U866 - U866, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, FT LAUDERDALE, FLORIDA, 05 May 2002 - 10 May 2002,
2002
Stern J; Skotnitsky C; O'Hare N; Tan J; Wong R; Sweeney DF; Holden BA, 2001, 'Comparison of the incidence of Contact Lens Papillary Conjuctivitis between six and thirty night high Dk soft extended wear schedules', in Investigative Ophthalmology and Visual Science, Association of Research Vision Ophthalmology Inc, Rockville, MD, USA, Vol. 42, pp. 597 - 597, presented at ARVO 2001: Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida, 29 April 2001 - 04 May 2001,
2001
O'Hare NA; Naduvilath T; Sweeney DF; Holden BA, 2001, 'A clinical comparison of limbal and paralimbal superior epithelial arcuate lesions (SEALs) in high Dk EW.', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Vol. 42, pp. S595 - S595,
2001
Sweeney DF; O'Hare N; Skotnitsky C; Stern J; Wong R; Navidulah T; Holden BA, 2001, 'Comparison of the performance of High Dk soft lens perfromance on 6 and 30 night extended wear schedules', in Investigative Ophthalmology and Visual Science, Association of Research Vision Ophthalmology Inc, Rockville, MD, USA, Vol. 42, pp. 597 - 597, presented at ARVO 2001: Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida, 29 April 2001 - 04 May 2001,
2001
Conference Posters
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Papas E; Dahms A; Carnt N; Tahhan N; Ehrmann K, 2009, 'Power profiles and short-term visual performance of soft contact lenses', Vol. 86, pp. 318 - 323,
2009
Journal articles
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Carnt NA; Cipriani V; Stapleton FJ; Calder V; Willcox MD, 2019, 'Association study of single nucleotide polymorphisms in IL-10 and IL-17 genes with the severity of microbial keratitis', Contact Lens and Anterior Eye,
2019
Garbutcheon-Singh KB; Carnt N; Pattamatta U; Samarawickrama C; White A; Calder V, 2019, 'A Review of the Cytokine IL-17 in Ocular Surface and Corneal Disease', Current Eye Research, vol. 44, pp. 1 - 10,
2019
2019, 'A Review of the Cytokine IL-17 in Ocular Surface and Corneal Disease', Current Eye Research, vol. 44, pp. 1 - 10,
2019
Kim D; Pattamatta U; Kelly E; Healey PR; Carnt N; Zoellner H; White AJ R, 2018, 'Inhibitory effects of angiotensin II receptor blockade on human tenon fibroblast migration and reactive oxygen species production in cell culture', Translational Vision Science and Technology, vol. 7,
2018
Kwon MS; Carnt NA; Truong NR; Pattamatta U; White AJ; Samarawickrama C; Cunningham AL, 2018, 'Dendritic cells in the cornea during Herpes simplex viral infection and inflammation', Survey of Ophthalmology, vol. 63, pp. 565 - 578,
2018
2018, 'Mucous Membrane Pemphigoid with Ocular Involvement: The Clinical Phenotype and Its Relationship to Direct Immunofluorescence Findings', Ophthalmology, vol. 125, pp. 496 - 504,
2018
Ong HS; Setterfield JF; Minassian DC; Dart JK; Booth D; Reid E; Carnt N; Gugliemetti S; Shanmuganathan V; Watson M; Saw V; Wilkins M; McCudden V; Ahmad S; Calder V; Waseem N; Scott B; Bunce C; Gage W; Gleeson M; Lund V; Sandhu G, 2018, 'Mucous Membrane Pemphigoid with Ocular Involvement: The Clinical Phenotype and Its Relationship to Direct Immunofluorescence Findings', Ophthalmology, vol. 125, pp. 496 - 504,
2018
Carnt N; Robaei D; Minassian DC; Dart JK G, 2018, 'Acanthamoeba keratitis in 194 patients: Risk factors for bad outcomes and severe inflammatory complications', British Journal of Ophthalmology, vol. 102, pp. 1431 - 1435,
2018
Carnt N; Hoffman JJ; Verma S; Hau S; Radford CF; Minassian DC; Dart JK G, 2018, 'Acanthamoeba keratitis: Confirmation of the UK outbreak and a prospective case-control study identifying contributing risk factors', British Journal of Ophthalmology, vol. 102, pp. 1621 - 1628,
2018
Samarawickrama C; Li Y-C; Carnt N; Willcox M; Dutta D; Watson S, 2017, 'Reducing oral contamination during corneal scrapes.', Bmj open ophthalmology, vol. 1, pp. e000044 - e000044,
2017
Carnt N, 2017, 'The TFOS 8th International Conference on the Tear Film & Ocular Surface: Basic Science and Clinical Relevance (Montpellier, France, September 7–10, 2016). Highlights from the Platform Sessions', Ocular Surface, vol. 15, pp. 257 - 263,
2017
Ung L; Pattamatta U; Carnt N; Wilkinson-Berka JL; Liew G; White AJ R, 2017, 'Oxidative stress and reactive oxygen species: A review of their role in ocular disease', Clinical Science, vol. 131, pp. 2865 - 2883,
2017
Sadik CD; Bischof J; van Beek N; Dieterich A; Benoit S; Sárdy M; Worm M; Meller S; Gläser R; Zillikens D; Homey B; Setterfield J; Minassian D; Schmidt E; Dart J; Ibrahim SM; Booth D; Reid E; Carnt N; Gugliemetti S; Shanmuganathan V; Watson M; Saw V; Wilkins M; McCudden V; Ahmad S; Bunce C; Günther C; Hadaschik E; Pföhler C; Schmieder A; Steinbrink K; Sticherling M, 2017, 'Genomewide association study identifies GALC as susceptibility gene for mucous membrane pemphigoid', Experimental Dermatology, vol. 26, pp. 1214 - 1220,
2017
Carnt N; Montanez VM; Galatowicz G; Veli N; Calder V, 2017, 'Tear cytokine levels in contact lens wearers with acanthamoeba keratitis', Cornea, vol. 36, pp. 791 - 798,
2017
Liskova P; Evans CJ; Davidson AE; Zaliova M; Dudakova L; Trkova M; Stranecky V; Carnt N; Plagnol V; Vincent AL; Tuft SJ; Hardcastle AJ, 2016, 'Heterozygous deletions at the ZEB1 locus verify haploinsufficiency as the mechanism of disease for posterior polymorphous corneal dystrophy type 3', European Journal of Human Genetics, vol. 24, pp. 985 - 991,
2016
Evans CJ; Davidson AE; Carnt N; Rojas Lòpez KE; Veli N; Thaung CM; Tuft SJ; Hardcastle AJ, 2016, 'Genotype-phenotype correlation for TGFBI corneal dystrophies identifies p.(G623D) as a novel cause of epithelial basement membrane dystrophy', Investigative Ophthalmology and Visual Science, vol. 57, pp. 5407 - 5414,
2016
Chidambaram JD; Prajna NV; Larke NL; Palepu S; Lanjewar S; Shah M; Elakkiya S; Lalitha P; Carnt N; Vesaluoma MH; Mason M; Hau S; Burton MJ, 2016, 'Prospective Study of the Diagnostic Accuracy of the In Vivo Laser Scanning Confocal Microscope for Severe Microbial Keratitis', Ophthalmology, vol. 123, pp. 2285 - 2293,
2016
Robaei D; Carnt N; Watson S, 2016, 'Established and emerging ancillary techniques in management of microbial keratitis: A review', British Journal of Ophthalmology, vol. 100, pp. 1163 - 1170,
2016
Carnt N; Robaei D; Watson SL; Minassian DC; Dart JK G, 2016, 'The Impact of Topical Corticosteroids Used in Conjunction with Antiamoebic Therapy on the Outcome of Acanthamoeba Keratitis', Ophthalmology, vol. 123, pp. 984 - 990,
2016
Kaye S; Sueke H; Romano V; Chen JY; Carnt N; Tuft S; Neal T, 2016, 'Impression membrane for the diagnosis of microbial keratitis', British Journal of Ophthalmology, vol. 100, pp. 607 - 610,
2016
Robaei D; Carnt N; Minassian DC; Dart JK G, 2015, 'Therapeutic and optical keratoplasty in the management of Acanthamoeba keratitis: Risk factors, outcomes, and summary of the literature', Ophthalmology, vol. 122, pp. 17 - 24,
2015
Davidson AE; Cheong SS; Hysi PG; Venturini C; Plagnol V; Ruddle JB; Ali H; Carnt N; Gardner JC; Hassan H; Gade E; Kearns L; Jelsig AM; Restori M; Webb TR; Laws D; Cosgrove M; Hertz JM; Russell-Eggitt I; Pilz DT; Hammond CJ; Tuft SJ; Hardcastle AJ, 2014, 'Association of CHRDL1 mutations and variants with X-linked megalocornea, Neuhäuser syndrome and central corneal thickness', PLoS ONE, vol. 9,
2014
Iovieno A; Gore DM; Carnt N; Dart JK, 2014, 'Acanthamoeba sclerokeratitis: Epidemiology, clinical features, and treatment outcomes', Ophthalmology, vol. 121, pp. 2340 - 2347,
2014
Robaei D; Carnt N; Minassian DC; Dart JK G, 2014, 'The impact of topical corticosteroid use before diagnosis on the outcome of Acanthamoeba keratitis', Ophthalmology, vol. 121, pp. 1383 - 1388,
2014
Dart JK G; Robaei D; Carnt N; Minassian DC, 2014, 'The Impact of Topical Corticosteroid Use before Diagnosis on the Outcome of Acanthamoeba Keratitis', Ophthalmology,
2014
Zhao Z; Naduvilath T; Flanagan JL; Carnt NA; Wei X; Diec J; Evans V; Willcox MD P, 2010, 'Contact lens deposits, adverse responses, and clinical ocular surface parameters', Optometry and Vision Science, vol. 87, pp. 669 - 674,
2010
Carnt N; Evans VE; Naduvilath T; Willcox MD; Papas EB; Frick K; Holden BA, 2009, 'Contact lens-related adverse event rates vary with the combination of silicone hydrogel lens and daily wear care system used.', Archives of Ophthalmology, vol. 127, pp. 1616 - 1623
2009
Zhao Z; Carnt NA; Aliwarga Y; Wei X; Naduvilath T; Garrett Q; Korth J; Willcox MD P, 2009, 'Care regimen and lens material influence on silicone hydrogel contact lens deposition', Optometry and Vision Science, vol. 86, pp. 251 - 259,
2009
Zhao Z; Wei X; Aliwarga Y; Carnt NA; Garrett Q; Willcox MD P, 2008, 'Proteomic analysis of protein deposits on worn daily wear silicone hydrogel contact lenses.', Molecular Vision, vol. 14, pp. 2016 - 2024
2008
Tan J; Papas E; Carnt N; Jalbert I; Skotnitsky C; Shiobara M; Lum E; Holden B, 2007, 'Performance standards for toric soft contact lenses', Optometry and Vision Science, vol. 84, pp. 422 - 428,
2007
O Hare N, 2002, 'Practitioner attitudes to extended and continuous wer of silicone hydrogels', Silicone Hydrogel Web Site, vol. October, pp. 1 - 5
2002