Revathy Mani

PhD Candidate

PhD Candidate

Research Title: Relationship of visual, oculomotor and cognitive deficits in traumatic brain injury

Supervisors: Dr Lisa AsperDr Sieu Khuu 

 

RESEARCH

Traumatic Brain Injury (TBI) is defined as traumatically induced structural brain damage caused by an external force resulting in physiological disruption of brain functions. It is a serious public health problem due to its acute and chronic debilitating consequences. It often leads to a myriad of social, emotional, cognitive and sensorimotor deficits. The first line of assessment often includes testing of neuropsychological functions which is time-consuming, influenced by educational, and cultural and background, and are not sensitive to detect subtle deficits in TBI. Neuroimaging techniques such as CT/MRI are expensive, need expertise and often fail to detect diffuse axonal injuries - the signature injury in TBI. Hence, there is a need for an objective, cost-effective and sensitive biomarker to detect and monitor TBI.

Deficits in saccadic and smooth-pursuit eye movements are often present in TBI owing to the vulnerability of the complex oculomotor circuitry in the frontal and parietal lobes – commonly affected areas of brain in TBI. Eye tracking technology provides an objective, non-invasive and sensitive tool. to evaluate reflexive, anti-, memory-guided, and self-paced saccades as well as smooth-pursuits. In addition, these unique protocols allow the evaluation of cognitive deficits along with the eye movements.

The results of our meta-analysis demonstrated voluntary eye movements such as antisaccades, memory-guided saccades and smooth-pursuits were more adversely affected in TBI than reflexive and self-paced saccades. Unlike reflexive saccades, these eye movement tasks involve higher cognitive load such as response-inhibition, working-memory and visuo-spatial information processing which are affected in TBI. Hence, it is unclear whether these oculomotor deficits are due to the difficulty in disengaging attention and/or working-memory load or difficulty in planning and execution of saccades. The aim of our study is to investigate the role of attention and working memory in antisaccades, memory-guided saccades and remembered antisaccade paradigms with different delays.

BIOGRAPHY 

Revathy Mani is a PhD candidate at the School of Optometry and Vision Science, UNSW, Sydney. Her area of research is to understand the relationship of visual, oculomotor and cognitive deficits in Traumatic Brain Injury. She received her Bachelors (2002) and MPhil degree (2011) in Optometry from Elite School of Optometry, affiliated to Birla Institute of Technology and Science(BITS), Pilani India. She joined Sankara Nethralaya (SN), a tertiary eye care centre in India in 2002 as an Optometrist. She was the Head of Department of Binocular Vision and Vision Therapy (2009-2016). She is a Fellow of the Neuro-optometric Rehabilitation Association, USA (2018). She is the recipient of the 2019 William C Ezell Fellowship Award from American Academy of Optometry Foundation.

 

Education:  

Fellowship in Neuro-Optometric Rehabilitation, 2018, Neuro-Optometric Rehabilitation Association (NORA), CA, USA    

Master of Philosophy (Optometry) 2011, Elite School of Optometry, Chennai, India, irla Institute of technology and Science (BITS), Pilani, India 

Bachelor of Science (Optometry) 2002, Elite School of Optometry, India & Birla Institute of technology and Science (BITS), Pilani, India 

 

RECENT PUBLICATIONS 

Journal Articles 

Ambika S, Ayisha Atiya, Revathy Mani et al., Visual and ocular profile of patients with acquired brain injury: A retrospective study. Submitted in Brain Injury, May 2019. 

Ashwini VC, Revathy Mani, Ambika S et al., Reading eye movements in traumatic brain injury. bioRxiv 496752; doi: https://doi.org/10.1101/496752. Submitted in Brain Injury, June 2019 

Mani, R, Asper, L, Khuu, SK. Deficits in saccades and smooth-pursuit eye movements in adults with traumatic brain injury: A systematic review and meta-analysis. Brain Injury 2018; 32(11):1315-1336 https://doi.org/10.1080/02699052.2018.1483030 PubMed PMID: 29913089 

Revathy Mani, Ashwini V C Reddy, Rizwana et al., Management of Convergence Insufficiency and Oculomotor Dysfunction: A Neuro-Optometric Perspective. Optometry and Visual Performance 2017;5 (2) 67-73. 

Kumar N, Mani R, & Hussaindeen. "Changes in stimulus and response AC/A ratio with vision therapy in Convergence Insufficiency." J Optom 2017; 10:169-175. https://doi.org/10.1016/j.optom.2016.10.001 PubMed Central PMCID: PMC5484784. 

Hussaindeen J, Mani R, Rakshit A, et al., "Natural history of idiopathic abducens nerve paresis in a young adult." J Optom 2016; 9:264-268. https://doi.org/10.1016/j.optom.2016.02.002 PubMed PMID: 27056464; PubMed Central PMCID: PMC5030314. 

Husaindeen J, Mani R, Agarkar S., et al., “Acute adult onset esotropia associated with Accommodative Spasm” Optom Vis Sci 2014;91: S46 -S51. doi: 10.1097/OPX.0000000000000182. PubMed PMID:24584303.  

 

Reports and Book Chapters:  

Mani, R, Asper, L, Khuu, SK. Deficits in saccades and smooth-pursuit eye movements in adults with traumatic brain injury: A systematic review and meta-analysis. Brain Injury 2018; 32(11):1315-1336 https://doi.org/10.1080/02699052.2018.1483030 PubMed PMID: 29913089 

 

AWARDS 

Recipient of 2019 William C Ezell Fellowship Award from American Academy of Optometry Foundation. 

Recipient of travel grant for the annual meeting of 2019 American Academy of Optometry and 2020 ARVO. 

HDR student representative for the Faculty of Science Research Committee for 2018. 

Recipient of SEMO Travel Grant Award: Mani, Revathy, Asper, Lisa and Khuu, Sieu. (2018) Deficits in saccades and smooth pursuit eye movements in mild and severe traumatic brain injury: a meta-analysis. 15th Scientific and 9th Educators Meeting in Optometry (SEMO), Deakin Downtown, Melbourne, April 2018. 

University International Post-Graduate Scholarship award (UIPA), 2016. 

 

CONFERENCE ATTENDANCE 

Revathy Mani, Sieu Khuu and Lisa Asper. The effect of visual delay cue on saccadic response during an antisaccade task. ARVO 2019 poster presentation. 

Sieu Khuu, Revathy Mani and Lisa Asper. The effect of post cueing delay on saccadic latency in the execution of remembered anti saccades. ARVO 2019 poster presentation. 

Revathy Mani, Lisa Asper and Sieu Khuu. Deficits in saccades and pursuit eye movements in mild and severe traumatic brain injury: a systematic review and meta-analysis.  Annual meeting of Neuro-Optometric Rehabilitation Association (NORA), St Louis, MO, USA, Sep 2018 

Mani, Revathy, Asper, Lisa and Khuu, Sieu. (2018) Deficits in saccades and smooth pursuit eye movements in mild and severe traumatic brain injury: a meta-analysis. 15th Scientific and 9th Educators Meeting in Optometry (SEMO), Deakin Downtown, Melbourne, April 2018. 

Revathy Mani. A case report on Post Traumatic Vision Syndrome. Annual meeting of NORA, Denver, Colorado, USA, Sep 2015  

Revathy Mani, Ambika, Smita et al., Profile of visually symptomatic subjects with acquired brain injury and the neuro-optometric rehabilitation – a case series. Indian Eye Research Group (IERG), - ARVO India Chapter, L V Prasad Eye Hospital, Hyderabad, July 2015 

Revathy Mani. Uses of Binasal Occlusions in Traumatic Brain Injury. Annual Meeting of NORA, Rayleigh, NC, USA, April 2014  

 

AFFILIATIONS AND MEMBERSHIPS 

Optometry Council of India  

Neuro-optometric Rehabilitation Association 

American Academy of Optometry 

Association of Research for Vision and Ophthalmology 

Research Collaborator with Sri Ramachandra Institute of Higher Education and Research, Chennai, India.