Samea Khan

PhD Candidate

Name: Samea Khan

Research Title: Ameliorative effect of Sitagliptin and Celery Seeds extract (Ajwain) in Alloxan induced diabetic rats

Supervisors: Mark Willcox, Maria Markoulli  

Email Address: samea.khan@unsw.edu.au

LinkedIn: linkedin.com/in/samea-khan-00aaa5161

Research Abstract    

Diabetes mellitus is a major chronic metabolic disorder characterised by hyperglycaemia due to deregulation either in insulin production or function. The risk of diabetes is not only hyperglycaemia in blood but can also be seen in different organs like liver, kidneys, heard and eyes. Diabetes leads to disturbances in the metabolism of carbohydrates, lipids and proteins. Lipid peroxidation causes generation of free radicals which in turn disturbs the redox potential. Hyperglycaemia-mediated oxidative stress along with other metabolic disorders activates the immune system which results in the production of inflammatory cytokines such as (TNF-a). To treat this disease many synthetic drugs are being used as hypoglycaemic agents. Many medicinal plants are rich sources of flavonoids, and these can reduce hyper glycemia and its related complications.  The study is aimed to evaluate the relative effects of sitagliptin and Celery Seeds (Ajwain) on Alloxan induced diabetic rats. Blood glucose levels and other biochemical parameters such as blood lipids and glycation of proteins will be assessed in serum. I will also examine the eyes of rats to determine whether the treatments can affect the architecture of corneal nerves. Expression of tumour necrosis factor (TNF-a) will be assessed through qRT-PCR and its protein will be analysed by ELISA.  Results will relate sitagliptin as synthetic chemical agent and Ajwain as a natural medicinal plant.         

Education

Year

Degree

Institute

2022-2026

PhD

UNSW

 

2013-2015

Master of Philosophy (Biochemistry &Molecular Biology)

 

Quaid-i- Azam University Islamabad, Pakistan

2011-2013

Masters in Biochemistry &Molecular Biology

Quaid-i- Azam University Islamabad, Pakistan

BIOGRAPHY

Short bio – 150 words max

I have completed my M.Phil. degree from Quaid-i-Azam University Islamabad, Pakistan in 2015. I joined Govt Post Graduate college Haripur in 2015, where I served as lecture Biochemistry for two years. Afterwards in 2017 I joined Virtual University of Pakistan as an Instructor at the department of Molecular Biology. Currently, I am a PhD student at UNSW and got the chance to work with Professor Mark Willcox and Maria Markoulli.

Publications

  • Samea Khan, Mahjabeen Khan, Khizra Maqsood. Tanveer Hussain, Noor‐ul‐Huda,  Muhammad Zeeshan.,2020. Is Pakistan prepared for the COVID‐19 epidemic? Aquestionnaire‐based survey.J Med Virol. 2020;1–9.
  • Samea Khan, Jawad ul Husnain, Muhammad Tariq Pervez, Tanveer Hussain, Khizra Maqsood. Next generation sequencing in clinical virology: A review of its applications Pure Appl. Biol., 9(4): 2356-2360, December, 2020
  • BIBI, R.,MAQBOOL, A., KHAN, S. and KHAN, J., 2018. Microcephaly–A Neurodevelopmental HereditaryDisorderwithEmergingDriftsOfZikaV.FUUASTJournalofBiology,8(1).
  • Mahjabeen Khan, Madeeha Afzal Noshin Daud and Samea Khan2015. Comparative Efficacy of Elisa and Pcr for the Diagnosis of Hepatitis C in Various Areas of Pakistan. World Journal of Zoology 10 (4): 295-297.
  • Amna Kausar1, Masroor Ellahi Babar, Samea Khan,M. Sheeraz. Ahmad controlling of polyphenol oxidase-based browning in selected fruits and vegetables. ISSN: 2708-7182 (Print); ISSN: 2708-7190 (Online)
  • Samea Khan, Usman Shah Gilani, Syed Muhammad Muslim Raza, Tanveer Hussain. Evaluation of General Awareness Among Professionals Regarding COVID-19: A Survey Based Study from Pakistan (Scientific Reports) (Accepted).
  • Tanveer Hussain, Usman Shah Gilani, Samea Khan, Syed Muhammad Muslim Raza Assessment of General Awareness Among Pakistani Students Regarding COVID-19 Outbreak. Children and youth services review 121 (2021) 105830.

Conference Presentations

  • Samea Khan,  Mirza Jawad ul Hasnain, Ayesha Maqbool, Majida Perveen, Tanveer Hussain.  Clinical Profile of Dengue Fever Cases in District Haripur, Pakistan: 2019. (Presented in the 8th International Conference on Biological and Computational Sciences organized by Department of Bioinformatics and Biosciences, Capital University of Science and Technology, Islamabad, Pakistan, held on November 28, 2020 online using Microsoft Teams Platform)
  • Samea Khan, Tahir Ali, Wajiha Khan, Uzma Khan,  Iram Murtaz. Melatonin co-administration enhanced Menthalongifolia (L.) biological-activites in a rat model of diabetes. (Abstract poster has been presented in 18th Annual World Congress Insulin Resistance Diabetes & Cardiovascular Disease)

Awards

University International Postgraduate Award (UIPA) at UNSW

Merit Scholarship throughout Masters at QAU

CONFERENCE ATTENDANCE

  • National Conference of Trends in Biochemistry and Molecular Biology at Department of Biochemistry Quaid-I-AzamUniversity Islamabad, February 2012.
  • Symposium on Bio photonics at Pakistan Institute of Engineering and Applied Sciences, March 2013.
  • International Conference on Agricultural and Food Science and 7th International Conference on Biotechnology and Bioengineering, October 2017.
  • Participated as a resource person in workshop on Biosafety and Biosecurity at Virtual university of Pakistan in collaboration with National Training & research laboratories and Sure Bio diagnostics & pharmaceuticals, January 2018.
  • International conference on hereditary diseases, molecular diagnosis and prevention strategies, March 29, 2018 department of molecular biology Virtual University of Pakistan.
  • Worked as an organizer in the bioinformatics workshop on “Hands-on-training on latest bioinformatics tools and technologies” on august 15-16, 2018 at Virtual University of Pakistan, department of bioinformatics and computational biology.

Memberships and Affiliations