Shyam Sunder Tummanapalli

Postdoctoral Research Fellow

Profile

Dr Shyam Sunder Tummanapalli, a Postdoctorial Research Scientist with a special interest in identifying ocular surface biomarkers in neurological disorders. His current research is primarily on tear-based biomarkers as they offer a relatively non-invasive collection option to blood, and can be collected for serial repeated measures to determine the progression of disease or to determine the therapeutic efficacy in clinical trials. His PhD research identified that the concentration of neuro-active peptides, specifically substance P, in the tears of those with type 1 diabetes can serve as a non-invasive biomarker for peripheral nerve damage. This work was critical as it allows early detection and may prevent the progression of diabetic peripheral neuropathy, a condition that causes recurring ulcers of the feet and in severe cases require amputation. He has been recognised with a Dean's Award for his Outstanding PhD Thesis entitled "Evaluation of corneal nerves & tear neuromediators in diabetic peripheral neuropathy".

His current projects include: 

  1. Investigating the ocular surface changes in diabetes-associated dry eyes.
  2. Investigating the markers of ocular surface inflammation in people with Multiple Sclerosis.
  3. Investigating the ocular surface biomarkers in people with migraine.

 

Research Groups

Ocular Surface Research

 

EDUCATION:

PhD (Optometry) – 2020

School of Optometry and Vision Science, University of New South Wales, Australia.

Bachelor of Clinical Optometry -2005

Bharati Vidyapeeth Deemed University Medical College, India.

 

AWARDS & ACHIEVEMENTS

2020 - Received Dean's Award for Outstanding PhD Thesis titled "Evaluation of corneal nerves & tear neuromediators in diabetic peripheral neuropathy". (https://www.optometry.unsw.edu.au/postdoctoral-research-fellow-receives-deans-award)

2017 - Won the best photo award for “Whirlpool in the eye”- A montage of in-vivo confocal images of corneal nerves demonstrating whorl-like pattern of the corneal sub-basal nerve plexus. School of optometry and vision sciences photo competition, University of New South Wales, Australia.

2015 - Best Scientific Poster Award. ESO's International vision science and optometry conference (EIVOC), Chennai, India. (Poster)

2014 - Grand first prize for the South Zone in the All-India Cooper Vision quiz contest. India.

2013 - Australian Leadership Awards Fellowship round, Brien Holden Vision Institute, Sydney, Australia.

2010 - Best scientific poster award. ESO's International vision science and optometry conference (EIVOC), Chennai, India.

2005 - Winning team member of contact lens quiz. Johnson & Johnson Vision Care Academy at Pune, India

2004 - Winning team member of Bausch & Lomb Rolling Trophy. All-India quiz contest organised by Bausch & Lomb University at New Delhi

 

GRANTS

2019 - Science PhD Writing Scholarship from the Faculty of Science, University of New South Wales, Australia.

2019 - Travel grant to attend the International Society for Contact Lens Research Scientific (ISCLR) Meeting, Singapore.

2019 - Travel grant from Juvenile Diabetes Research Foundation, Australia.

2018 - Postgraduate Research Student Support (PRSS) funding, University of New South Wales, Australia.

2016 - University of New South Wales Tuition Fee Scholarship (TFS) for study toward a PhD in the Optometry and Vision Science, Sydney, Australia.

2015 - Travel grant. ESO's International Vision science and Optometry Conference (EIVOC), Chennai, India.

2015 - Travel Grant from International Association of Contact Lens Educators (IACLE) to participate in the "Association of Optometric Contact Lens Educators (AOCLE)" workshop at Southern college of Optometry, Memphis, Tennessee, US.

 

PUBLICATIONS:

  1. Tummanapalli SS, Kuppusamy R, Yeo JH, Kumar N, New EJ, Willcox MDP. The role of nitric oxide in ocular surface physiology and pathophysiology. Ocul Surf. 2021 (Accepted: https://authors.elsevier.com/tracking/article/details.do?aid=631&jid=JTOS&surname=Tummanapalli)
  2. Issar T, Tummanapalli SS, Borire AA, Kwai NCG, Poynten AM, Arnold R, Markoulli M, Krishnan AV. Impact of the metabolic syndrome on peripheral nerve structure and function in type 2 diabetes. Eur J Neurol. 2021 Mar. Epub ahead of print. PMID: 33682297.
  3. Tummanapalli SS, Willcox MDP. Antimicrobial resistance of ocular microbes and the role of antimicrobial peptides.Clin Exp Optom. 2020 Apr. PubMed PMID: 32924208.
  4. Issar T, Tummanapalli SS, Kwai N, Chung J, Markoulli M, Arnold Ria, Poynten AM, Krishnan AV Associations between acute glucose control and peripheral nerve structure and function in type 1 diabetes, Diabet Med. 2020 Apr 16. PubMed PMID: 32298478.
  5. Tummanapalli SS, Issar T, Kwai N, Pisarcikova J, Poynten AM, Krishnan AV, Willcox MDP, Markoulli M. A comparative study on the diagnostic utility of corneal confocal microscopy and tear neuromediator levels in diabetic peripheral neuropathy. Curr Eye Res. 2019 Dec 26:1-10. PubMed PMID: 31842622.
  6. Tummanapalli SS, Issar T, Kwai N, Poynten AM, Krishnan AV, Willcox MDP, Markoulli M. Corneal nerve fiber loss in diabetes with chronic kidney disease. Ocul Surf. 2019 Nov 23. PubMed PMID: 31770601.
  7. Tummanapalli SS, Issar T, Kwai N, Poynten AM, Krishnan AV, Willcox MDP, Markoulli M. Association of corneal nerve loss with markers of axonal ion channel dysfunction in type 1 diabetes. Clinical Neurophysiology Journal. Clin Neurophysiol. 2019;131(1):145–154. PubMed PMID: 31765978.
  8. Tummanapalli SS, Willcox MDP, Issar T, Kwai N, Poynten AM, Krishnan AV, Pisarcikova J, Markoulli M. The Effect of Age, Gender and Body Mass Index on Tear Film Neuromediators and Corneal Nerves. Curr Eye Res. 2019 Sep 18:1-8. PubMed PMID: 31507209.
  9. Tummanapalli SS, Willcox MDP, Issar T, Yan A, Pisarcikova J, Kwai N, PoyntenAM, Krishnan AV, Markoulli M. Tear film substance P: A potential biomarker for diabetic peripheral neuropathy. Ocul Surf. 2019;17(4):690–698. PubMed PMID: 31476517.
  10. Yan A, Issar T, Tummanapalli SS, Markoulli M, Kwai NCG, Poynten AM, Krishnan AV. Relationship between corneal confocal microscopy and markers of peripheral nerve structure and function in Type 2 diabetes. Diabet Med. 2019 Mar 21. PubMed PMID: 30897245.
  11. Markoulli M, Flanagan J, Tummanapalli SS, Wu J, Willcox M. The impact of diabetes on corneal nerve morphology and ocular surface integrity. Ocul Surf. 2018 Jan;16(1):45-57. PubMed PMID: 29113918.
  12. Tummanapalli SS, Markoulli M. Dry eyes and Diabetes. New Zealand Optics 2016.
  13. Tummanapalli SS, Potluri H, Vaddavalli PK, Sangwan VS. Efficacy of axial and tangential corneal topography maps in detecting subclinical keratoconus. J Cataract Refract Surg. 2015 Oct;41(10):2205-14. PubMed PMID: 26703297.
  14. Tummanapalli SS, Maseedupally V, Varsha M. Rathi. Reply: Pellucid marginal degeneration and keratoconus; Differential diagnosis by corneal topography. J Cataract Refract Surg. 2013 Jun; 39(6):968-969. PubMed PMID: 23688901.
  15. Tummanapalli SS, Maseedupally V, Mandathara P, Rathi VM, Sangwan VS. Evaluation of corneal elevation and thickness indices in pellucid marginal degeneration and keratoconus. J Cataract Refract Surg. 2013 Jan;39(1):56-65. PubMed PMID: 23107832.
  16. Kumbar T, Tummanapalli SS, Swati J, Fathima A, Addepally UK, Rao HL, Rathi VM. Correlation of Back Optic Zone Radius measurement of rigid contact lenses with radiuscope and keratometer. Cont Lens Anterior Eye. 2012 Dec;35(6):282-4. PubMed PMID: 23017211.

 

Conference Papers

  1. Zahari I, Tummanapalli SS, Colorado L; Markoulli M; Pritchard N; Schmid K, Efron N, Edwards K. Exploring novel features in the corneal nerve plexus in a healthy population: globular cells and microneuromas at Association for Research in Vision and Ophthalmology (ARVO) - 2020, Baltimore, US.
  2. Issar T, Tummanapalli SS, Kwai N, Arnold R, Poynten A, Markoulli M, Krishnan A. The effect of hyperglycaemia and glucose variability on peripheral nerve structure and function in type 1 diabetes at International Diabetes Federation (IDF) Congress - 2019, Busan, Korea.
  3. Tummanapalli SS, Willcox M, Issar T, Yan A, Pisarcikova J, Kwai N, Poynten A, Krishnan A, Markoulli M. Reduced tear film substance P concentration is associated with diabetic peripheral neuropathy at Association for Research in Vision and Ophthalmology (ARVO) - 2019, Vancouver, Canada.
  4. Tummanapalli SS, Willcox M, Issar T, Kwai N, Poynten A, Krishnan A, Markoulli M. Assessment of corneal nerve structure and peripheral nerve function in detection of diabetic peripheral neuropathy at Association for Research in Vision and Ophthalmology (ARVO) - 2018, Honolulu, Hawaii.
  5. Rajini Peguda, Anna Yang, Tyson Xu, Tummanapalli SS, Helen Swarbrick. Morphological changes in the bulbar conjunctiva with short term mini-scleral contact lens wear. Association for Research in Vision and Ophthalmology (ARVO) - 2018 in Honolulu, Hawaii.
  6. Tummanapalli SS, Issar T, Kwai N, Poynten A, Krishnan A, Willcox M, Markoulli M. The relationship between structural and electrophysiological measures of peripheral nerves in human type 1 diabetes. International Diabetes Federation (IDF) Congress - 2017, Abu Dhabi, United Arab Emirates.
  7. Tummanapalli SS, Potluri H, Vaddavalli PK, Sangwan VS. Efficacy of Axial and Tangential Corneal Topography Maps in Detecting Subclinical Keratoconus: A novel diagnostic index. ESO's International vision science and optometry conference (EIVOC) - 2015, Chennai, India.
  8. Vaddavalli PK, Tummanapalli SS, Kalaiselvan P, Kumar P, Dumpati S. Assessing progression of keratoconus using corneal topography. American society of cataract and refractive surgery - 2015, San Diego, CA.
  9. Parthasarathi K, Tummanapalli SS, Vaddavalli PK. Comparison and correlation of asphericity in anterior and posterior keratoconus. 36th All India optometry conference - 2014, Agra, India.
  10. Tummanapalli SS, Potluri H, Vaddavalli PK, Sangwan VS. Efficacy of Axial and Tangential Corneal Topography Maps in Detecting Subclinical Keratoconus. Association for Research in Vision and Ophthalmology (ARVO) - 2012, Florida.USA.
  11. Tummanapalli SS, Potluri H, Vaddavalli PK, Sangwan VS. Efficacy of Axial and Tangential Corneal Topography Maps in Detecting Subclinical Keratoconus: A novel diagnostic index. India – UK initiative Knowledge of Economy Partnership. International seminar - 2012, University of Hyderabad.
  12. Tummanapalli SS, Maseedupally V, Mandathara P, Rathi VM, Sangwan VS “Evaluation of corneal elevation and thickness indices in pellucid marginal corneal degeneration and keratoconus. Asia- Association for Research in Vision and Ophthalmology (Asia- ARVO) - 2011, Singapore.
  13. Tummanapalli SS, Maseedupally V, Mandathara P, Rathi VM, Sangwan VS “Evaluation of corneal elevation and thickness indices in pellucid marginal corneal degeneration and keratoconus”. ESO's International vision science and optometry conference (EIVOC) - 2010, Chennai, India.
  14. Maseedupally V, Mandathara P, Dumpati S, Tummanapalli SS “Orbscan IIz corneal indices in normal and keratoconic eyes”. Asia-Association for Research in Vision and Ophthalmology (Asia- ARVO) - 2009, Hyderabad, India

 

Conference Presentations  

  1. Tummanapalli SS, Willcox M, Issar T, Pisarcikova J, Kwai N, Poynten A, Krishnan A, Poynten A, Markoulli M. Effect of ageing on tear film neuropeptides and corneal nerves. 20th Scientific Meeting of the International Society for Contact Lens Research (ISCLR) - 2019, Singapore.
  2. Tummanapalli SS, Issar T, Kwai N, Poynten A, Krishnan A, Willcox M, Markoulli M. Corneal confocal microscopy detects peripheral neuropathy in type 2 diabetes with chronic kidney disease". Australasian Diabetes Congress - 2018, Adelaide. Australia.
  3. Tummanapalli SS. Speciality contact lenses. Eye-PEP (Post-graduate Education Program) - 2014, LV Prasad Eye Institute, India.
  4. Tummanapalli SS. Recent advances in contact lens fitting for irregular cornea. Alumni of L V Prasad Eye Institute Optometrists - 2014. LV Prasad Eye Institute, India.
  5. Tummanapalli SS, Mandathara P, Maseedupally V, Rathi V. Evaluation of corneal and thickness indices in pellucid marginal corneal degeneration and keratoconus. Indian Eye Research Group - 2010. LV Prasad Eye Institute, India.
  6. Tummanapalli SS. Spectacle dispensing. Eye-PEP (Post-graduate Education Program) - 2008. LV Prasad Eye Institute, India

 

INVITED PRESENTATIONS

  1. 2020 - "Evaluation of corneal nerves and tear neuromediators in diabetic peripheral neuropathy" presented School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Australia.

 

IN THE MEDIA

  1. 2020 - Future Medicine. Tear film may help assess diabetic neuropathy. https://www.futuremedicineindia.com/tear-film-may-help-assess-diabetic-neuropathy/
  2. 2019 - Medical Insider. Tear Analysis - A New Method in Diagnosing Diabetes Complications. https://medicalinsider.ru/news/analiz-slezy-novyjj-metod-v-diagnostike-oslozhnenijjdiabeta/
  3. 2019 - ABC Radio National. New tear test to screen for type 1 diabetic peripheral neuropathy.  https://www.abc.net.au/radionational/programs/drive/research-filter-tears-diabetes-pigs-tools-dogs-longevity/11591670
  4. 2019 - Review of Optometry. The news feed. Nerve loss may indicate kidney problems. https://www.reviewofoptometry.com/news/article/nerve-loss-may-indicate-kidney-problems
  5. 2019 - Review of Optometry. Researchers find new diagnostic clues in tears. Substance P may operate as a potential biomarker in diabetes. https://www.reviewofoptometry.com/article/researchers-find-new-diagnostic-clues-in-tears
  6. 2019 - Mirage News. Tear samples could help detect diabetes complication. https://www.miragenews.com/tear-samples-could-help-detect-diabetes-complication/
  7. 2019 - Optometry Australia. Tears can help detect diabetic peripheral nerve damage.https://www.optometry.org.au/patient_care_management/tears-can-help-detect-diabetic-peripheral-nervedamage/
  8. 2019 - Medical Dialogues. Tears can predict peripheral neuropathy in type 1 diabetes patients. https://speciality.medicaldialogues.in/tears-can-predict-peripheral-neuropathy-in-type-1-diabetespatients-diabetes-complications/
  9. 2019 - UNSW Newsroom. Tear samples could help detect diabetes complication. https://newsroom.unsw.edu.au/news/science-tech/tear-samples-could-help-detect-diabetescomplication
  10. 2019 - Medical express. Marker in tear samples could detect diabetes complication. https://medicalxpress.com/news/2019-10-marker-samples-diabetes-complication.html
  11. 2014 - The Hindu newspaper. For your eyes. https://www.thehindu.com/todays-paper/tp-features/tpsundaymagazine/for-your-eyes-only/article6492380.ece