Efficient literature searching and critical appraisal of clinical literature are two critical skills defining the practice of evidence-based medicine. PubMed is one of the most important sources of information for healthcare providers and in the past 2 years, PubMed has been updated to improve functionality and add important new features. This Viewpoint describes how these important new PubMed features and functions can allow clinicians to use a simple 3-step literature searching process to obtain real-time answers to important clinical questions.