The Australian Society for Microbiology and UNSW School of Optometry and Vision Science invites you to attend a presentation from Bob Hancock, Department of Microbiology and Immunology from the University of British Columbia, Vancouver, Canada on Thursday 18 July 2019 from 5pm - 6.30pm. All students, staff, alumni, general public more than welcome to attend.
Date: 18 July 2019
Time: 5.00pm - 6.30pm
Location: Rupert Myers Theatre, M15 on campus map, North Wing Rupert Myers Building, Gate 14 Barker Street, UNSW Sydney, Kensington NSW 2052
Presentation title: Alternatives to Antibiotics for Multidrug Resistant Infections and Inflammation
Presenter: R.E.W. (Bob) Hancock, Dept. Microbiology and Immunology, UBC, Vancouver, Canada
Abstract: The inexorable increase in multidrug resistant infections combined with a decrease in new antibiotic discovery and the lack of compounds to treat recalcitrant infections, such as those associated with sepsis and chronic infections, is creating a potential crisis in human medicine. Thus it is imperative to consider alternatives to conventional antibiotics for treating infections.
I will discuss four examples, namely:
(1) an approach to address immune dysfunction in sepsis based on a predictive diagnostic gene expression signature of cellular reprogramming;
(2) immunomodulatory peptides based on a template of natural cationic host defence (antimicrobial) peptides, which protect against infections and inflammation;
(3) a new strategy for identifying host-directed therapies based on the use of mutated stem cells and;
(4) a class of broad-spectrum peptides that acts against chronic and biofilm infections.